| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NI.3247 |
| P1325 | external data available at URL | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE70798 |
| P932 | PMC publication ID | 4632529 |
| P698 | PubMed publication ID | 26237550 |
| P50 | author | David Zemmour | Q58791483 |
| Christophe Benoist | Q87765385 | ||
| P2093 | author name string | Diane Mathis | |
| Matthew Meredith | |||
| P2860 | cites work | Aire's partners in the molecular control of immunological tolerance | Q24296286 |
| The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression | Q24316299 | ||
| Chromosomal clustering of genes controlled by the aire transcription factor | Q24527311 | ||
| The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. | Q38309456 | ||
| AIRE activated tissue specific genes have histone modifications associated with inactive chromatin | Q39801026 | ||
| Transcription of individual genes in eukaryotic cells occurs randomly and infrequently | Q41475012 | ||
| Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Q41836564 | ||
| AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells | Q41849042 | ||
| The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells | Q41861103 | ||
| Promiscuous mRNA splicing under the control of AIRE in medullary thymic epithelial cells. | Q42775864 | ||
| Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. | Q53253030 | ||
| Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity. | Q53569120 | ||
| Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. | Q54067406 | ||
| The cellular mechanism of Aire control of T cell tolerance. | Q55041159 | ||
| The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression | Q57407953 | ||
| Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells | Q74310402 | ||
| Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation | Q24630856 | ||
| Transcriptional regulation by AIRE: molecular mechanisms of central tolerance | Q24648384 | ||
| Deletional tolerance mediated by extrathymic Aire-expressing cells | Q24652952 | ||
| Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells | Q27329941 | ||
| AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome | Q27674604 | ||
| Stochastic gene expression in a single cell | Q28131784 | ||
| Projection of an immunological self shadow within the thymus by the aire protein | Q28207164 | ||
| Aire regulates negative selection of organ-specific T cells | Q28213185 | ||
| Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells | Q28239651 | ||
| Large-scale analysis of the human and mouse transcriptomes | Q29547360 | ||
| Control of stochasticity in eukaryotic gene expression | Q29615955 | ||
| Regulation of noise in the expression of a single gene | Q29616626 | ||
| Quantitative assessment of single-cell RNA-sequencing methods. | Q33619848 | ||
| Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling | Q33848902 | ||
| APCluster: an R package for affinity propagation clustering | Q33954147 | ||
| Bayesian approach to single-cell differential expression analysis | Q33955732 | ||
| CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification | Q34297012 | ||
| Single-cell sequencing-based technologies will revolutionize whole-organism science | Q34360540 | ||
| Quantitative single-cell RNA-seq with unique molecular identifiers | Q34393809 | ||
| AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix | Q34470421 | ||
| Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia | Q34590391 | ||
| Single-cell RNA-seq reveals dynamic paracrine control of cellular variation | Q35185544 | ||
| Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells | Q35673793 | ||
| Evidence for a single-niche model of positive selection | Q35930529 | ||
| High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire | Q36376026 | ||
| Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism | Q36392973 | ||
| Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels | Q36402949 | ||
| Aire-dependent thymic development of tumor-associated regulatory T cells | Q36754190 | ||
| Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. | Q36948991 | ||
| The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription | Q36949002 | ||
| Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated | Q36949091 | ||
| Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity | Q37173204 | ||
| The impact of negative selection on thymocyte migration in the medulla. | Q37476326 | ||
| An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription | Q37544045 | ||
| P4510 | describes a project that uses | CEL-seq | Q105426380 |
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | RNA sequencing | Q2542347 |
| single cell transcriptomics | Q105406038 | ||
| P304 | page(s) | 942-949 | |
| P577 | publication date | 2015-08-03 | |
| P1433 | published in | Nature Immunology | Q1071725 |
| P1476 | title | Aire controls gene expression in the thymic epithelium with ordered stochasticity | |
| P478 | volume | 16 |
| Q89046279 | A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation |
| Q98611670 | A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion |
| Q38773105 | AIRE expands: new roles in immune tolerance and beyond. |
| Q47227251 | AIRE: a missing link to explain female susceptibility to autoimmune diseases. |
| Q40449499 | Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance. |
| Q38810897 | Autoimmune regulator and self-tolerance - molecular and clinical aspects |
| Q55001559 | Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice. |
| Q27308795 | CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance |
| Q90341344 | CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction |
| Q93017603 | Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation |
| Q36303674 | Central tolerance to self revealed by the autoimmune regulator |
| Q96817033 | Chd4 choreographs self-antigen expression for central immune tolerance |
| Q47825842 | Chemokine-Mediated Choreography of Thymocyte Development and Selection. |
| Q39274318 | Childhood Polyarthritis As Early Manifestation of Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy Syndrome. |
| Q85929770 | Co-ordination of intrathymic self-representation |
| Q57072688 | Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development |
| Q51119669 | DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. |
| Q38810900 | Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen |
| Q91522090 | Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance |
| Q38662800 | EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes. |
| Q40487587 | Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells |
| Q40257193 | Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. |
| Q39187317 | Generation of diversity in thymic epithelial cells. |
| Q93049115 | Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response |
| Q39328219 | IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes |
| Q58598501 | Influence of correlated antigen presentation on T-cell negative selection in the thymus |
| Q38833533 | JingleBells: A Repository of Immune-Related Single-Cell RNA-Sequencing Datasets |
| Q90627993 | Lessons from primary immunodeficiencies: Autoimmune regulator and autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy |
| Q64052753 | Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance |
| Q64924555 | Meta-Analysis of Autoimmune Regulator-Regulated Genes in Human and Murine Models: A Novel Human Model Provides Insights on the Role of Autoimmune Regulator in Regulating STAT1 and STAT1-Regulated Genes. |
| Q47102239 | MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors. |
| Q47442891 | Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen |
| Q28075590 | Novel Findings into AIRE Genetics and Functioning: Clinical Implications |
| Q52311688 | Nuclear Factor-kappaB in Autoimmunity: Man and Mouse. |
| Q48207560 | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils |
| Q38682042 | Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity |
| Q92758750 | Primary Immunodeficiency with Severe Multi-Organ Immune Dysregulation |
| Q64886183 | RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development. |
| Q48239289 | Rapid chromatin repression by Aire provides precise control of immune tolerance |
| Q98611677 | Recollections of the discovery of promiscuous antigen expression in mTECs |
| Q104459140 | Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds |
| Q64949232 | Regulatory Role of CD4+ T Cells in Myocarditis. |
| Q46008364 | Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation. |
| Q55267276 | Role of Polyamines in Immune Cell Functions. |
| Q26767443 | Signaling in T cells - is anything the m(a)TOR with the picture(s)? |
| Q38769681 | Single-Cell Genomics: Approaches and Utility in Immunology |
| Q38645486 | Single-cell RNA sequencing to explore immune cell heterogeneity |
| Q47734588 | Single-cell RNA-sequencing resolves self-antigen expression during mTEC development |
| Q50055143 | Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. |
| Q59066334 | Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells |
| Q26775923 | Single-cell technologies are revolutionizing the approach to rare cells |
| Q52897581 | Switching on the Aire conditioner. |
| Q36994050 | Systems biology: A tool for charting the antiviral landscape |
| Q91639005 | The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response |
| Q50562460 | The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation. |
| Q39386100 | The multiple pathways to autoimmunity |
| Q41858982 | The transcriptional regulator Aire binds to and activates super-enhancers |
| Q91718584 | Thymic epithelial cell heterogeneity: TEC by TEC |
| Q64935581 | Thymic tolerance as a key brake on autoimmunity. |
| Q47614075 | Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis. |
| Q93371103 | Thymus machinery for T-cell selection |
| Q40766117 | Thymus medulla under construction: Time and space oddities. |
| Q40414012 | Transcriptional programs that control expression of the autoimmune regulator gene Aire |
| Q50420265 | Transcriptional regulation and development of regulatory T cells. |
| Q50314118 | Twenty Years of AIRE. |
| Q47856335 | Update on Aire and thymic negative selection |
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