| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M408797200 |
| P698 | PubMed publication ID | 15364915 |
| P50 | author | Dan Littman | Q5213885 |
| Mari Maeda-Yamamoto | Q57692516 | ||
| P2093 | author name string | Michael Leitges | |
| David J Rawlings | |||
| Jiro Kitaura | |||
| Toshiaki Kawakami | |||
| Yuko Kawakami | |||
| Roberta M Kato | |||
| Hajime Nishimoto | |||
| P2860 | cites work | Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3 | Q24309262 |
| The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 | ||
| Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase | Q24682825 | ||
| Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Q27860731 | ||
| Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 | ||
| Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking | Q28118280 | ||
| Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343 | Q28213632 | ||
| Characterization of PDK2 activity against protein kinase B gamma | Q28216896 | ||
| Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site | Q28373472 | ||
| Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase | Q28609845 | ||
| Role of translocation in the activation and function of protein kinase B | Q28609902 | ||
| Immunodeficiency in protein kinase cbeta-deficient mice | Q28616043 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase | Q29618387 | ||
| Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C | Q29620247 | ||
| PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. | Q33860504 | ||
| PKB/AKT: functional insights from genetic models | Q34389540 | ||
| Ten years of protein kinase B signalling: a hard Akt to follow | Q34432885 | ||
| Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm | Q35031770 | ||
| Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk | Q35160038 | ||
| A Ras activation pathway dependent on Syk phosphorylation of protein kinase C | Q35234778 | ||
| Akt-dependent cytokine production in mast cells | Q36368818 | ||
| Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase | Q40803478 | ||
| PDK1, one of the missing links in insulin signal transduction? | Q41553975 | ||
| A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice | Q41719698 | ||
| Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. | Q44101117 | ||
| Expression and properties of two types of protein kinase C: alternative splicing from a single gene | Q48344126 | ||
| The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells | Q57272881 | ||
| PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes | Q58617364 | ||
| P433 | issue | 46 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| P304 | page(s) | 47720-47725 | |
| P577 | publication date | 2004-09-09 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion | |
| P478 | volume | 279 |
| Q43080792 | 12-O-tetradecanoylphorbol-1, 3-acetate induces the negative regulation of protein kinase B by protein kinase Calpha during gastric cancer cell apoptosis. |
| Q41727733 | 14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells. |
| Q24672490 | A comprehensive pathway map of epidermal growth factor receptor signaling |
| Q39372532 | A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation |
| Q33384375 | A phase I trial of enzastaurin in patients with recurrent gliomas |
| Q35994422 | AKT regulates BRCA1 stability in response to hormone signaling |
| Q37238629 | Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A. |
| Q30494741 | Akt isoforms differentially regulate neutrophil functions |
| Q37721192 | Akt signaling in platelets and thrombosis |
| Q30478648 | Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation |
| Q37877409 | Anti-angiogenic therapy in glioma |
| Q27468836 | Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload |
| Q36228028 | BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism |
| Q24632097 | Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA |
| Q90720642 | CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2 |
| Q47652919 | Calcium signalling links MYC to NUAK1. |
| Q24321723 | Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis |
| Q42826775 | Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways |
| Q37313698 | Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation |
| Q44399229 | Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. |
| Q40177635 | Critical role for classical PKC in activating Akt by phospholipase A2-modified LDL in monocytic cells |
| Q40369116 | Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. |
| Q42116134 | Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport |
| Q33369369 | Discovery of a novel class of AKT pleckstrin homology domain inhibitors |
| Q36746834 | Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia |
| Q45928369 | EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells. |
| Q34813937 | EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. |
| Q99555085 | Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation |
| Q39956127 | Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs |
| Q33388272 | Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study |
| Q29615120 | Exploiting the PI3K/AKT pathway for cancer drug discovery |
| Q40202640 | Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells |
| Q36739639 | Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liver |
| Q39525805 | HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells. |
| Q37257571 | HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus |
| Q35106306 | HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread |
| Q39232932 | Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation |
| Q45591122 | Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells. |
| Q28771765 | Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53 |
| Q46009469 | Interplay between MEK and PI3 kinase signaling regulates the subcellular localization of protein kinases ERK1/2 and Akt upon oxidative stress. |
| Q40084736 | Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells. |
| Q33806065 | Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells |
| Q35639741 | Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. |
| Q42701477 | Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention |
| Q42290027 | Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells |
| Q33621811 | NF-kappaB-dependent induction of cathelicidin-related antimicrobial peptide in murine mast cells by lipopolysaccharide |
| Q40445871 | Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. |
| Q38198095 | Novel therapies, including enzastaurin, in the treatment of ovarian cancer |
| Q37339512 | Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway |
| Q33341346 | PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle |
| Q30436921 | PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells |
| Q37101645 | PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1. |
| Q27317259 | PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control |
| Q35106609 | PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses |
| Q39401591 | PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation. |
| Q35570248 | Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma |
| Q41489017 | Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils |
| Q28485326 | Pleckstrin homology domain of Akt kinase: a proof of principle for highly specific and effective non-enzymatic anti-cancer target |
| Q40084195 | Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis |
| Q37157311 | Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis |
| Q24604987 | Protein kinases and phosphatases in the control of cell fate |
| Q24646815 | Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells |
| Q37215135 | Requirement for Rictor in homeostasis and function of mature B lymphoid cells. |
| Q34806539 | Retracted: Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines |
| Q38613674 | Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii. |
| Q36680692 | Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: proposal of a unified hypothesis |
| Q36517697 | Specific protein kinase C isoforms as transducers and modulators of insulin signaling |
| Q37185828 | Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells |
| Q37002380 | Survival of monocytes and macrophages and their role in health and disease |
| Q34144420 | TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha |
| Q39760304 | Targeting PKC-β II and PKB Connection: Design of Dual Inhibitors |
| Q52579980 | Targeting the protein kinase C family: are we there yet? |
| Q36313193 | The Akt/PKB pathway: molecular target for cancer drug discovery |
| Q33770769 | The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors |
| Q51547435 | The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin. |
| Q38042382 | The chemical biology of phosphoinositide 3-kinases |
| Q39984715 | The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells |
| Q39986126 | The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. |
| Q36745379 | The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer |
| Q33884698 | Therapeutic strategies with oral fluoropyrimidine anticancer agent, S-1 against oral cancer |
| Q42542192 | Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia |
| Q36880063 | Vitamin E and mast cells |
| Q48578193 | cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway |
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