AKT regulates BRCA1 stability in response to hormone signaling

scientific article

AKT regulates BRCA1 stability in response to hormone signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MCE.2010.01.019
P932PMC publication ID4548798
P698PubMed publication ID20085797

P2093author name stringKirk C Hansen
Jeffrey T Holt
Steven M Anderson
Traci R Lyons
Andrew C Nelson
Christian D Young
P2860cites workEstrogen receptor alpha rapidly activates the IGF-1 receptor pathwayQ22253479
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damageQ24292278
Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activityQ24306083
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domainsQ24306945
BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase AQ24315124
BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogenQ24316813
Identification of a RING protein that can interact in vivo with the BRCA1 gene productQ24324342
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteQ24554478
Negative Regulation of AKT Activation by BRCA1Q24644153
Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domainsQ24645684
BRCA1 is a component of the RNA polymerase II holoenzymeQ24675704
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide stainingQ24682187
Structure of a BRCA1-BARD1 heterodimeric RING-RING complexQ27635007
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1Q28115843
Repeated observation of breast tumor subtypes in independent gene expression data setsQ28131820
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage responseQ28140763
Genetic analysis of BRCA1 function in a defined tumor cell lineQ28142643
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cellsQ28146113
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activityQ28215490
Linkage of early-onset familial breast cancer to chromosome 17q21Q28268902
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cellsQ28363087
Brca1 controls homology-directed DNA repairQ29614844
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouseQ29618622
Hallmarks of 'BRCAness' in sporadic cancersQ29618825
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damageQ29619360
Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.Q30157958
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cellsQ33652431
Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGFQ33911108
Emerging roles of BRCA1 alternative splicingQ33919195
BRCA1 transcriptionally regulates genes involved in breast tumorigenesisQ34064538
Regulation of BRCA1, BRCA2 and BARD1 intracellular traffickingQ34444026
Hormonal prevention of hereditary breast cancerQ34497393
Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancerQ34609774
Regulation of progesterone receptor signaling by BRCA1 in mammary cancerQ34652156
Hormone-dependent regulation of BRCA1 in human breast cancer cells.Q34719862
IGF-I, GH, and sex steroid effects in normal mammary gland developmentQ34889024
Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligaseQ35749504
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivityQ35865833
Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1Q35924811
Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genesQ36032594
Regulation of signal transduction pathways by estrogen and progesteroneQ36041030
Prevention and management of hereditary breast cancerQ36065462
BRCA1 is a cell cycle-regulated nuclear phosphoproteinQ36648552
BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancerQ36732507
IGF ligand and receptor regulation of mammary developmentQ37149891
Crosstalk between IGF1R and estrogen receptor signaling in breast cancer.Q37323603
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonistQ40202330
Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.Q40551207
Estrogen receptors: bioactivities and interactions with cell signaling pathwaysQ41096911
Reduction of BRCA1 expression in sporadic ovarian cancerQ41720959
BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repairQ42473523
Identification of BRCA1-IRIS, a BRCA1 locus productQ42636849
Adenovirus transduction of 3T3-L1 cellsQ42831133
An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expressionQ44495836
Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin/Akt signaling pathwayQ44683477
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.Q45057108
IGF and insulin receptor signaling in breast cancer.Q46240548
Estrogen upregulation of BRCA1 expression with no effect on localizationQ47878271
BRCA1 expression is not directly responsive to estrogenQ48055063
BRCA1 protein products ... Functional motifs...Q48062839
Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells.Q52523736
Gene-Expression Profiles in Hereditary Breast CancerQ57240053
BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected CellsQ60568779
Location of BRCA1 in human breast and ovarian cancer cellsQ70998780
Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progressionQ72345882
Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant miceQ94461300
P433issue1-2
P304page(s)129-142
P577publication date2010-01-18
P1433published inMolecular and Cellular EndocrinologyQ1573600
P1476titleAKT regulates BRCA1 stability in response to hormone signaling
P478volume319

Reverse relations

cites work (P2860)
Q36534034"DNA Binding Region" of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint
Q35169608AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers
Q64948494BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance.
Q37720033BRCA1 regulates insulin-like growth factor 1 receptor levels in ovarian cancer
Q34481443Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair
Q57493678Elucidating the novel BRCA1 function as a non-genomic metabolic restraint in ER-positive breast cancer cell lines
Q35961713Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers
Q34764674Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer
Q38062611IGF-1 and BRCA1 signalling pathways in familial cancer
Q36652248Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells
Q52644526New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response.
Q37001693Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes
Q37611723Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination System
Q54274892The PI3K/AKT/mTOR interactive pathway.
Q27027457Therapeutic targeting of replicative immortality
Q34260212Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3.

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