PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients

scientific article published on 30 August 2011

PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-11-1244
P932PMC publication ID3195839
P698PubMed publication ID21878536

P50authorGeorge G. NettoQ74759772
William B IsaacsQ89161930
Jessica HicksQ96146588
Wennuan LiuQ101050166
David M EsopiQ114718054
Siobhan SutcliffeQ49392833
Angelo M De MarzoQ56417148
Alan W PartinQ62089936
Tamara L LotanQ62091289
Jianfeng XuQ67190177
P2093author name stringMisop Han
Ben H Park
Bora Gurel
Elizabeth Humphreys
P2860cites workEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Pten dose dictates cancer progression in the prostateQ24791909
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.Q27851411
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
MMAC1/PTEN mutations in primary tumor specimens and tumor cell linesQ28256046
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Integrative genomic profiling of human prostate cancerQ29619905
Agarose mold embedding of cultured cells for tissue microarraysQ30310276
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Q30472730
Practical methods for tissue microarray construction.Q30772247
Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasisQ33266259
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Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostateQ81000526
Natural history of progression after PSA elevation following radical prostatectomyQ33611613
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancerQ33723651
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformationQ34109986
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.Q34973214
Subtle variations in Pten dose determine cancer susceptibilityQ35055350
Considerations when analyzing the methylation status of PTEN tumor suppressor geneQ35788734
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndromeQ36847856
Pten inactivation and the emergence of androgen-independent prostate cancer.Q36885813
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.Q37250634
Post-translational regulation of PTEN.Q37270440
Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progressionQ37383459
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cellsQ37437827
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.Q38467346
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostateQ39506775
A robust immunohistochemical assay for detecting PTEN expression in human tumorsQ39646962
MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC).Q39728869
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasiasQ40293372
PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cellsQ40508012
Is PTEN loss associated with clinical outcome measures in human prostate cancer?Q43249619
Identification of a pseudogene that can masquerade as a mutant allele of the PTEN/MMAC1 tumor suppressor gene.Q46894426
Genetic alterations in the PI3K pathway in prostate cancer.Q47797768
PTEN/MMAC1/TEP1 involvement in primary prostate cancers.Q47814101
Frequent inactivation of PTEN in prostate cancer cell lines and xenograftsQ47855108
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancerQ47919199
Frequent inactivation of PTEN/MMAC1 in primary prostate cancerQ57240096
Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcomeQ57790493
ThePTEN gene in locally progressive prostate cancer is preferentially inactivated by bi-allelic gene deletionQ63966367
Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancerQ73235041
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissuesQ74093343
Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomasQ74418921
Analysis of PTEN and the 10q23 region in primary prostate carcinomasQ74531155
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)6563-6573
P577publication date2011-08-30
P1433published inClinical Cancer ResearchQ332253
P1476titlePTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
P478volume17

Reverse relations

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