Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model

scientific article

Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.YMETH.2014.11.001
P698PubMed publication ID25461816

P50authorXavier Matias-Guiu GuiaQ62016438
Maria SantacanaQ39032703
Oscar MaiquesQ44529136
P2093author name stringXavier Dolcet
Núria Eritja
Xavier Gonzalez-Tallada
P2860cites workEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
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PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 casesQ73622060
PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapyQ74715361
Cell adhesion molecules as tumour suppressorsQ75293348
Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinomaQ77879703
Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarityQ85028296
PTEN function: how normal cells control it and tumour cells lose itQ24528114
A coding-independent function of gene and pseudogene mRNAs regulates tumour biologyQ24632651
miR-19 is a key oncogenic component of mir-17-92Q24652326
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Advances in the formation, use and understanding of multi-cellular spheroidsQ26828808
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTENQ28141881
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
PTEN1 is frequently mutated in primary endometrial carcinomasQ28250937
Integrated genomic characterization of endometrial carcinomaQ28289962
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Pten is essential for embryonic development and tumour suppressionQ28509238
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
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MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN.Q33755798
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Accommodating haploinsufficient tumor suppressor genes in Knudson's modelQ33986221
Mutations of the human PTEN geneQ33988995
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancerQ34103462
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformationQ34109986
Prognostic significance of miR-205 in endometrial cancerQ34238901
Pathologic scoring of PTEN immunohistochemistry in endometrial carcinoma is highly reproducibleQ34574472
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional culturesQ34674397
Comprehensive miRNA profiling of surgically staged endometrial cancerQ34779785
Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling.Q35185712
Considerations when analyzing the methylation status of PTEN tumor suppressor geneQ35788734
Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencingQ35926060
MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN.Q35974749
ERα-mediated repression of pro-inflammatory cytokine expression by glucocorticoids reveals a crucial role for TNFα and IL1α in lumen formation and maintenanceQ35990014
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
Cell polarity in development and cancer.Q36925556
Relationship between PTEN, DNA mismatch repair, and tumor histotype in endometrial carcinoma: retained positive expression of PTEN preferentially identifies sporadic non-endometrioid carcinomasQ37038863
mTOR signaling feedback modulates mammary epithelial differentiation and restrains invasion downstream of PTEN lossQ37156750
Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterusQ37280170
The epithelial polarity program: machineries involved and their hijacking by cancer.Q37333603
Polarity proteins in migration and invasionQ37333610
Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cellsQ37351516
PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model systemQ37382529
Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.Q37401876
NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β inductionQ37615954
Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?Q37638254
Epithelial organization, cell polarity and tumorigenesisQ37904131
Loss of PTEN expression as a prognostic marker for tongue cancerQ38458513
PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patientsQ38738670
Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β-catenin signalingQ39046697
MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN.Q39077654
MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cellsQ39160607
MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancerQ39183436
MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN.Q39356550
A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroidsQ39459919
MicroRNA-221 and -222 regulate radiation sensitivity by targeting the PTEN pathwayQ39560767
Role of microRNA-214-targeting phosphatase and tensin homolog in advanced glycation end product-induced apoptosis delay in monocytesQ39608598
A robust immunohistochemical assay for detecting PTEN expression in human tumorsQ39646962
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.Q40178894
Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors.Q40464853
Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalitiesQ40485163
Ultrastructure of endometrial epithelial cells in a three-dimensional cell culture system for human implantation studiesQ40970211
Ultrastructural characterization of two new human endometrial carcinoma cell lines and normal human endometrial epithelial cells cultured on extracellular matrixQ41137235
MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN.Q41412784
Culture of human endometrial cells under polarizing conditionsQ42484600
Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthaseQ43038834
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinomaQ43049041
Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern ChinaQ43456119
Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancerQ43675669
Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPaseQ44298545
Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissuesQ44529091
Scaffold-mediated symmetry breaking by Cdc42pQ44661094
Growth of mouse endometrial luminal epithelial cells in vitro: functional integrity of the oestrogen receptor system and failure of oestrogen to induce proliferationQ44973323
Best practice for PTEN gene and protein assessment in anatomic pathologyQ46825031
Cell polarity and cancer--cell and tissue polarity as a non-canonical tumor suppressor.Q52586148
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.Q53956406
P921main subjectendometrial cancerQ944777
P304page(s)31-40
P577publication date2014-11-18
P1433published inMethodsQ6823859
P1476titleModeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model
P478volume77-78

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cites work (P2860)
Q87056285A rapid guide to PTEN function
Q39026766Endometrial Carcinoma: Specific Targeted Pathways.
Q57170070Modeling Endometrial Cancer: Past, Present, and Future
Q64114534Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology
Q35967172Role of MicroRNAs in carcinogenesis that potential for biomarker of endometrial cancer

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