SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model

scientific article published on 07 June 2016

SAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1530/ERC-16-0103
P932PMC publication ID4959547
P698PubMed publication ID27267120

P2093author name stringLi Zhao
Dong Wook Kim
Sheue-Yann Cheng
Mark C Willingham
Xuguang Zhu
P2860cites workPhase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)Q24681480
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitorQ27853093
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
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Lost in transcription: p21 repression, mechanisms, and consequencesQ28251319
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drugQ28282479
The landscape of somatic copy-number alteration across human cancersQ29547648
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphomaQ33375600
FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphomaQ33377159
Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinomaQ33381498
Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.Q33390876
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Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathwaysQ33736109
Src-dependent ezrin phosphorylation in adhesion-mediated signalingQ33914506
Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptorQ34478795
Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulationQ34528284
Histone deacetylases and cancer: causes and therapiesQ34570082
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progressionQ35070405
TSH-activated signaling pathways in thyroid tumorigenesisQ35736825
PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancerQ36278234
Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptorQ36439404
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer CellsQ36715993
Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptorQ36748109
Evaluation of Romidepsin for Clinical Activity and Radioactive Iodine Reuptake in Radioactive Iodine–Refractory Thyroid CarcinomaQ36813563
Histone deacetylase inhibitors: molecular mechanisms of actionQ36908440
Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormoneQ37288003
Phase I Trial of a New Schedule of Romidepsin in Patients with Advanced CancersQ37667088
Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancerQ37767709
Radioiodine for remnant ablation and therapy of metastatic diseaseQ37913996
HDAC inhibitors in cancer biology: emerging mechanisms and clinical applicationsQ37962333
Mechanisms of Resistance to Histone Deacetylase InhibitorsQ38054220
p21WAF1 and tumourigenesis: 20 years afterQ38060451
Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environmentQ39525953
Activity of deacetylase inhibitor panobinostat (LBH589) in cutaneous T-cell lymphoma models: Defining molecular mechanisms of resistanceQ39744464
Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.Q39791600
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphomaQ39981886
Akt- and MAPK-mediated activation and secretion of MMP-9 into stroma in breast cancer cells upon heregulin treatment.Q40029865
The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cellsQ40098928
Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivoQ40227787
Novel histone deacetylase inhibitors in the treatment of thyroid cancerQ40422202
Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switchQ46909608
Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesisQ52548664
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancerQ53330585
P433issue7
P921main subjectcarcinogenesisQ1637543
P304page(s)521-533
P577publication date2016-06-07
P1433published inEndocrine-Related CancerQ3054004
P1476titleSAHA-induced loss of tumor suppressor Pten gene promotes thyroid carcinogenesis in a mouse model
P478volume23

Reverse relations

cites work (P2860)
Q42101746Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer
Q42666368MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/β-Catenin Pathway in Thyroid Cancer.

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