MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells

scientific article published on 01 September 2018

MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/CARCIN/BGY092
P932PMC publication ID6148990
P698PubMed publication ID29985991

P2093author name stringHong Wu
David D Eisenstat
Roger P Leng
Benfan Wang
Chengsen Chai
P2860cites workmiR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kineticsQ21091130
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulationQ24655473
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translationQ28143010
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
Cellular survival: a play in three AktsQ29547806
MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTENQ29616575
Natural RNA circles function as efficient microRNA spongesQ29617892
miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patientsQ31136911
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosisQ33762003
Biology, metastatic patterns, and treatment of patients with triple-negative breast cancerQ34058510
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.Q34318634
Triple-negative breast cancer: clinical features and patterns of recurrenceQ34658655
RNAdb 2.0--an expanded database of mammalian non-coding RNAsQ35545831
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Molecular classification and molecular forecasting of breast cancer: ready for clinical application?Q36250255
1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498.Q36436094
Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndromeQ36718983
PTEN mutation, methylation and expression in breast cancer patientsQ37092758
MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression.Q37190254
Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial designQ37418501
NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β inductionQ37615954
Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancerQ37708804
A miRNA signature associated with human metastatic medullary thyroid carcinoma.Q38311922
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPasesQ38525479
MicroRNA-498 is downregulated in non-small cell lung cancer and correlates with tumor progressionQ38839257
Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylationQ40732720
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylationQ40767550
Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent mannerQ41835165
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53.Q42814656
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.Q42944792
Promoter methylation and silencing of PTEN in gastric carcinomaQ43918868
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.Q43940083
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomasQ48045473
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.Q48054446
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivoQ48722189
MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells.Q51014377
Low miR-498 expression levels are associated with poor prognosis in ovarian cancer.Q53216488
Plaque assay techniques for murine leukemia virusesQ93694433
P4510describes a project that usesImageJQ1659584
P433issue9
P921main subjectcell migrationQ189092
P304page(s)1185-1196
P577publication date2018-09-01
P1433published inCarcinogenesisQ326022
P1476titleMicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells
P478volume39

Reverse relations

cites work (P2860)
Q91755923Downregulation of miR-505 promotes cell proliferation, migration and invasion, and predicts poor prognosis in breast cancer
Q61443284FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG
Q96820713LncRNA HOTAIRM1 Inhibits the Proliferation and Invasion of Lung Adenocarcinoma Cells via the miR-498/WWOX Axis
Q90090954Long Non-Coding RNA Taurine Upregulated Gene 1 (TUG1) Downregulation Constrains Cell Proliferation and Invasion through Regulating Cell Division Cycle 42 (CDC42) Expression Via MiR-498 in Esophageal Squamous Cell Carcinoma Cells
Q61447414MiR-182-5p Knockdown Targeting PTEN Inhibits Cell Proliferation and Invasion of Breast Cancer Cells
Q90698082MicroRNA-212 suppresses cell proliferation in nasopharyngeal carcinoma by targeting ELF3
Q90613540MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer
Q90568606The Regulatory Role of MicroRNAs in Breast Cancer

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