Crosstalk between Nrf2 and Notch signaling.

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Crosstalk between Nrf2 and Notch signaling. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2015.05.017
P8608Fatcat IDrelease_ufede4e2fbfppiybbtphwq755y
P932PMC publication ID4628857
P698PubMed publication ID26003520
P5875ResearchGate publication ID277144701

P50authorThomas W KenslerQ55816017
P2093author name stringNobunao Wakabayashi
Dionysios V Chartoumpekis
P2860cites workFunctional diversity among Notch1, Notch2, and Notch3 receptorsQ45345854
GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress.Q46898715
A reproducible and well-tolerated method for 2/3 partial hepatectomy in miceQ47564825
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathwayQ47762057
Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cellsQ47910775
Neural fate decisions mediated by trans-activation and cis-inhibition in Notch signalingQ48105377
The mammalian cap and collar family of transcription factorsQ48645786
Selenium in the redox regulation of the Nrf2 and the Wnt pathway.Q50855740
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.Q51069614
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.Q51951782
beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.Q52182997
Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine modelQ58003958
Functional conservation of Notch1 and Notch2 intracellular domainsQ81752509
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalkQ24294545
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Q24300456
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayQ24305237
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesisQ24309150
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionQ24310885
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in miceQ24317348
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsQ24320364
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Q24563807
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainQ24609907
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2Q24650743
Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liverQ24680214
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
Non-canonical Notch signaling: emerging role and mechanismQ26863550
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagyQ27685461
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Notch signaling: cell fate control and signal integration in developmentQ27861061
HES and HERP families: multiple effectors of the Notch signaling pathwayQ28205103
Adult neurogenesis and neural stem cells of the central nervous system in mammalsQ28219915
Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive elementQ28240487
Signalling through the lipid products of phosphoinositide-3-OH kinaseQ28241516
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
Comprehensive genomic characterization of head and neck squamous cell carcinomasQ28256121
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signallingQ28262816
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous systemQ28292445
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activityQ28296400
Discovery and saturation analysis of cancer genes across 21 tumour typesQ28305204
Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1Q28388436
Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infectionQ28396451
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistanceQ28505114
Conservation of the Notch signalling pathway in mammalian neurogenesisQ28513429
Notch1 is essential for postnatal hair follicle development and homeostasisQ28513742
Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regenerationQ28564785
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complexQ28609062
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayQ29547371
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsQ29614268
Notch1 functions as a tumor suppressor in mouse skinQ29614987
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationQ29616127
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationQ29618051
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and developmentQ29620011
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenalsQ30497261
Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmasQ33556193
Nrf2: friend or foe for chemoprevention?Q33575690
Viral carcinogenesis: revelation of molecular mechanisms and etiology of human diseaseQ33846198
Wnt signalling in mammalian development and cancerQ33870394
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).Q33969345
The notch intracellular domain can function as a coactivator for LEF-1Q34012680
Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liverQ34028523
Regulation of notch1 signaling by nrf2: implications for tissue regenerationQ34101123
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysisQ34146310
Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.Q34151863
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.Q39582561
Selective use of ADAM10 and ADAM17 in activation of Notch1 signalingQ39808768
Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis.Q40222228
Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesisQ40424064
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cellsQ40874695
Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.Q41301488
Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signalingQ42461064
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoterQ42604393
Selective oxidation of DNA topoisomerase 1 induces systemic sclerosis in the mouse.Q42800745
Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activationQ42803384
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.Q45345845
Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stressQ34229596
The PTEN/NRF2 axis promotes human carcinogenesisQ34579435
Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicityQ34737012
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signalingQ35168476
Self-renewal and cancer of the gut: two sides of a coin.Q36080124
Roles of bHLH genes in neural stem cell differentiationQ36144904
Keap1 degradation by autophagy for the maintenance of redox homeostasisQ36187388
The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expressionQ36315299
Skin stem cells: rising to the surfaceQ36404865
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.Q36467640
Notch and Wnt signaling: mimicry and manipulation by gamma herpesvirusesQ36480684
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.Q36528951
Notch signaling in stem cell systemsQ36556388
WNT/beta-catenin signaling in liver health and diseaseQ36804161
Notch Signaling in the VasculatureQ36861805
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.Q36994927
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signalingQ37098168
Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signalingQ37106139
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancerQ37158989
Notch signaling regulates tubular morphogenesis during repair from biliary damage in miceQ37184171
Notch3: from subtle structural differences to functional diversityQ37256439
The Notch signaling pathway: transcriptional regulation at Notch target genesQ37376057
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.Q37524270
Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling.Q37546854
Discovery of the negative regulator of Nrf2, Keap1: a historical overviewQ37743470
Mechanism and significance of cis-inhibition in Notch signalling.Q37826900
Notch in T-ALL: new players in a complex disease.Q37903126
New insights into the mechanism of notch signalling in fibrosis.Q38026842
To divide or not to divide: revisiting liver regenerationQ38115855
Non-canonical notch signaling in cancer and immunityQ38299924
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermisQ38308641
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse developmentQ38347755
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancerQ38893164
P433issuePt B
P304page(s)158-167
P577publication date2015-05-21
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleCrosstalk between Nrf2 and Notch signaling
P478volume88

Reverse relations

cites work (P2860)
Q88998667A Role for Nrf2 Expression in Defining the Aging of Hippocampal Neural Stem Cells
Q42575032A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology.
Q54981824Age-dependent regulation of antioxidant genes by p38α MAPK in the liver.
Q39248568Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress.
Q28078928Emerging roles of Nrf2 signal in non-small cell lung cancer
Q49834826KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane
Q38927510Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals
Q37121524Mutations and expression of the NFE2L2/KEAP1/CUL3 pathway in Chinese patients with lung squamous cell carcinoma.
Q92105332New Lipid Mediators in Retinal Angiogenesis and Retinopathy
Q38845270Notch signaling in lung diseases: focus on Notch1 and Notch3.
Q93003838Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments
Q28066915Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad
Q28398010Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)
Q38618135Nrf2 regulates cellular behaviors and Notch signaling in oral squamous cell carcinoma cells
Q64250962PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling
Q48271468Prospects for new lung cancer treatments that target EMT signaling
Q38820186Prostaglandins and Other Lipid Mediators (POLM), Special Issue of the 6th European workshop on lipid mediators: Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.
Q33829585Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis
Q88646850Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target
Q93102412The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System
Q42005885The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases
Q39377881The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance
Q41975269Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells.
Q64235522miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia-Effect of cannabinoids
Q38893853p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

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