FHIT: from gene discovery to cancer treatment and prevention

scientific article

FHIT: from gene discovery to cancer treatment and prevention is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(02)00931-2
P698PubMed publication ID12473516

P50authorCarlo Maria CroceQ640381
P2093author name stringKay Huebner
Nicola Zanesi
Alexey Palamarchuk
Yuri Pekarsky
P2860cites workLoss of heterozygosity of chromosome 3p markers in small-cell lung cancerQ41332396
Origin of genes encoding multi-enzymatic proteins in eukaryotes.Q41549764
Molecular follow-up of preneoplastic lesions in bronchial epithelium of former Chernobyl clean-up workersQ43955974
The FHIT gene 3p14.2 is abnormal in lung cancerQ53455201
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysisQ58072287
Tumor suppressor genesQ68264184
Role of chromosome translocations in human neoplasiaQ68818574
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytesQ70378721
Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphomaQ70449918
Clonal genetic alterations in the lungs of current and former smokersQ73443322
The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaQ73549634
Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site inductionQ74306391
The tumor suppressor protein Fhit. A novel interaction with tubulinQ78122448
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of FhitQ24313542
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegansQ24317206
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolaseQ24320228
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancersQ24321912
The tumor spectrum in FHIT-deficient miceQ24555215
Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/FhitQ24595534
Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 geneQ24644705
Muir-Torre-like syndrome in Fhit-deficient miceQ24676755
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Replacement of Fhit in cancer cells suppresses tumorigenicityQ33726007
The histidine triad superfamily of nucleotide-binding proteinsQ33738439
Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instabilityQ33963998
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell linesQ34019362
Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studiesQ34442403
FHIT gene therapy prevents tumor development in Fhit-deficient mice.Q34729169
The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle controlQ35552007
Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.Q36396981
The use of epidemiology, scientific data, and regulatory authority to determine risk factors in cancer of some organs of the digestive system. 2. Esophageal cancerQ36489743
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological featuresQ36621318
Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletionQ36827321
Chromosome aberrations and cancerQ37538405
Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sitesQ37559058
Frequent altered expression of fragile histidine triad protein in human colorectal adenomasQ40843340
P433issue12
P921main subjectpreventionQ1717246
gene discoveryQ129262352
P1104number of pages7
P304page(s)748-754
P577publication date2002-12-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inLancet Oncology CommissionQ13747613
P1476titleFHIT: from gene discovery to cancer treatment and prevention
P478volume3

Reverse relations

cites work (P2860)
Q446833565'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas
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Q30543570Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.
Q61809987Aggressive genomic features in clinically indolent primary HHV8-negative effusion-based lymphoma
Q37708066Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis
Q40414760Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines
Q30670527Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ
Q38614582CRISPR/Cas9: molecular tool for gene therapy to target genome and epigenome in the treatment of lung cancer
Q33531934Chromosomal imbalances are uncommon in chagasic megaesophagus
Q44614687Chromosome arm 8p and cancer: a fragile hypothesis.
Q34156955Comparative analysis of algorithms for integration of copy number and expression data
Q45103584Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma.
Q46497555Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome
Q28252440Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer
Q40368333Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR.
Q35147070Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
Q43275576FHIT gene sequence variants and reduced Fhit protein expression in glioblastoma multiforme
Q44827323FHIT mRNA and protein expression in hepatocellular carcinoma
Q46235892FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia
Q35191084FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
Q40274111Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines
Q39771185Fhit regulates invasion of lung tumor cells
Q37352008Fhit tumor suppressor: guardian of the preneoplastic genome
Q33761959Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung cancer cells
Q46733687Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas
Q35877178Gallbladder cancer: lessons from a rare tumour
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Q37948622HPV, KRAS mutations, alcohol consumption and tobacco smoking effects on esophageal squamous-cell carcinoma carcinogenesis.
Q57261261High resolution analysis of follicular lymphoma genomes reveals somatic recurrent sites of copy-neutral loss of heterozygosity and copy number alterations that target single genes
Q83820573High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia
Q42258973Human papillomavirus and non-small cell lung cancer
Q34444611Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer
Q34118625Identification of putative cancer genes through data integration and comparative genomics between plants and humans.
Q37272413Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins
Q34650922Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
Q46489933Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma
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Q44623571Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer.
Q33866516Loss of fragile histidine triad protein expression in inflammatory bowel disease
Q36655128Methylation in esophageal carcinogenesis
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Q35563102Search for unknown tumor‐antagonizing genes
Q26828610Serine, glycine and one-carbon units: cancer metabolism in full circle
Q40339478Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia
Q36610527The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions
Q36299944The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
Q35112786Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis
Q92920001Translatable gene therapy for lung cancer using Crispr CAS9-an exploratory review
Q97532078Upregulation of FHIT gene expression in endometrial carcinoma by RNA activation
Q21283974Widespread presence of "bacterial-like" PPP phosphatases in eukaryotes

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