Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis

scientific article

Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/HED.20833
P932PMC publication ID3046044
P698PubMed publication ID18446839
P5875ResearchGate publication ID5405269

P2093author name stringBiao He
David M Jablons
Liang You
Zhidong Xu
Yu-Ching Lin
Jae Kim
Josephine Chou
P2860cites workMatrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomasQ80544879
Association of E-cadherin and beta-catenin with metastasis in nasopharyngeal carcinomaQ80551012
Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinomaQ80559739
[Expression and significance of PTEN in nasopharyngeal carcinoma]Q81409600
Expression of p53 protein and primary tumour volume in patients with nasopharyngeal carcinomaQ81807931
[Cross-talk between c-Jun/Ets1 involved in EB virus-encoded latent membrane protein 1 regulates expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma]Q81836777
Prognostic value of Survivin and Livin in nasopharyngeal carcinomaQ82567403
[Significance of EGFR and p-ERK expression in nasopharyngeal carcinoma]Q83884933
[The relationship between hypermethylation of the PTEN promoter and laryngeal squamous cell carcinoma]Q83890595
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
Control of apoptosis and mitotic spindle checkpoint by survivinQ22008570
Chfr defines a mitotic stress checkpoint that delays entry into metaphaseQ22254761
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathwaysQ24321528
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphomaQ24322614
Cyclooxygenase regulates angiogenesis induced by colon cancer cellsQ24336248
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cellsQ24554359
Epigenetic inactivation of CHFR in human tumorsQ24670147
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5Q24675583
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complexQ24685706
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
The retinoblastoma protein and cell cycle controlQ27860722
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
The DNA damage response: putting checkpoints in perspectiveQ28131713
Loss of p16 expression has prognostic significance in human nasopharyngeal carcinomaQ38451930
Loss of cyclin D1 and p16 expression correlates with local recurrence in nasopharyngeal carcinoma following radiotherapyQ38455460
Oral mucosal tumor inhibition by ibuprofen.Q38522173
Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groupsQ38896500
Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesisQ39444400
A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.Q39736828
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cellsQ39795545
Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinasesQ40117040
Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cellsQ40131916
Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growthQ40138689
Wnt inhibitory factor inhibits lung cancer cell growthQ40167186
Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signalingQ40192981
Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cellsQ40209246
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cellsQ34564031
HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysisQ34570497
Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinomaQ34570584
Nasopharyngeal cancer in Greenland. The incidence in an Arctic Eskimo populationQ34618090
Telomerase inhibition and the future management of head-and-neck cancerQ34688638
The effect of migration on the risk of nasopharyngeal cancer among Chinese.Q34700342
LMP1 strain variants: biological and molecular properties.Q34717145
Undifferentiated nasopharyngeal cancer (UCNT): current diagnostic and therapeutic aspectsQ34722621
Increased MAPK expression and activity in primary human hepatocellular carcinomaQ34741778
An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinkingQ35000168
Genetic and epigenetic changes in nasopharyngeal carcinoma.Q35008876
Matrix metalloproteinases in tumor-host cell communicationQ35030681
Identification of CDK4 as a target of c-MYC.Q35051802
Epstein-Barr virus-recent advancesQ35076846
The p53 network in head and neck cancerQ35078417
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.Q35122385
Regulators of G1 cyclin-dependent kinases and cancersQ35186469
Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implicationsQ35588568
Down-regulation of Cdk inhibitor p27 in oral squamous cell carcinoma.Q36032530
Wnt signaling in lung cancerQ36101348
Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis.Q36167487
Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cellsQ36242117
Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinomaQ36611031
Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcriptsQ36696963
Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.Q36810617
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancerQ37376029
Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasiaQ37429299
Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cellsQ37583544
Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway.Q37595549
Prognostic factors of nasopharyngeal carcinoma: a review of 759 patientsQ38052106
Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinomaQ38273731
Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated Wnt signaling pathwayQ38309301
Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancerQ38435843
Frequent genetic and biochemical alterations of the PI 3-K/AKT/PTEN pathway in head and neck squamous cell carcinomaQ38445188
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomasQ28202829
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activityQ28209840
The Fos family of transcription factors and their role in tumourigenesisQ28275076
Cell cycle targets of Ras/Raf signallingQ28285940
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugsQ28291174
Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosisQ28344462
Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase AQ28618873
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
Regulation of transcription by MAP kinase cascadesQ29618477
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathQ29620000
Cancer Incidence in Five Continents. Comparability and quality of dataQ30809860
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.Q31105358
The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal carcinomaQ32045194
Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expressionQ32120327
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9Q33265945
MYC oncogenes and human neoplastic diseaseQ33667340
Role of p27 in prostate carcinogenesisQ33715175
Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signalingQ33781678
New insights into the control of MAP kinase pathwaysQ33783573
Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2.Q33815241
Matrix metalloproteases in head and neck cancerQ33863220
Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent mannerQ33962291
Matrix metalloproteinases in tumor invasion and metastasisQ34136635
Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancerQ34222573
Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasisQ34228703
Genetic and biochemical dissection of protein linkages in the cadherin-catenin complexQ34287597
BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathwaysQ34320007
Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cellsQ34351473
Translocations involving c-myc and c-myc functionQ34405431
The activation of Akt/PKB signaling pathway and cell survival.Q34405519
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosisQ34442990
Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell linesQ34486671
Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progressionQ34494021
Cloning and characterization of the BRD7 gene promoterQ34540911
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1.Q34551310
CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinomaQ40247402
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomeraseQ40281326
Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cellsQ40293195
The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancerQ40299123
Celecoxib induces dose dependent growth inhibition in nasopharyngeal carcinoma cell lines independent of cyclooxygenase-2 expressionQ40310448
Regulation of survivin and CDK4 by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cell lines.Q40358529
Host cyclooxygenase-2 modulates carcinoma growth.Q40365112
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.Q40399583
Epstein-Barr virus LMP1 initiates cell proliferation and apoptosis inhibition via regulating expression of Survivin in nasopharyngeal carcinoma.Q40402154
Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylationQ40413167
Latent membrane protein 1 encoded by Epstein-Barr virus modulates directly and synchronously cyclin D1 and p16 by newly forming a c-Jun/Jun B heterodimer in nasopharyngeal carcinoma cell lineQ40413322
Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression.Q40455834
Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1.Q40470698
Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells.Q40481455
MDM2 expression in EBV-infected nasopharyngeal carcinoma cellsQ40510932
Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein-Barr virus encoded latent membrane protein 1.Q40538392
Cooperative interactions among p53, bcl-2 and Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma cellsQ40547103
Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell lineQ40558959
RECK is a target of Epstein–Barr virus latent membrane protein 1Q40616852
Alterations of Biologic Properties and Gene Expression in Nasopharyngeal Epithelial Cells by the Epstein-Barr Virus–Encoded Latent Membrane Protein 1Q40647912
Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapyQ40734444
Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells.Q40766371
Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinomaQ40860124
A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cellsQ40912553
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cellsQ40993570
Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1).Q41044165
Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virusQ41436239
Changing views of the role of matrix metalloproteinases in metastasisQ41592276
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor roleQ41674960
Deregulated cyclin E induces chromosome instabilityQ41692394
Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product.Q42130716
High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?Q42491304
Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.Q42500751
Transient activation of c-Jun NH2-terminal kinase by growth factors influences survival but not apoptosis of human thyrocytesQ42508079
Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysisQ43482949
IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas.Q43643486
Promoter hypermethylation of multiple genes in nasopharyngeal carcinomaQ43860639
Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinomaQ45249203
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.Q45286100
Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cellsQ45444546
Prognostic role of Ebstein-Barr virus latent membrane protein-1 and interleukin-10 expression in patients with nasopharyngeal carcinomaQ45546964
Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell linesQ45584265
Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphomaQ45605928
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.Q45729612
Association of p53 and BCL-2 expression with Epstein-Barr virus infection in the cancers of head and neckQ45736565
Co-expression of p53 and bcl-2 may correlate to the presence of epstein-barr virus genome and the expression of proliferating cell nuclear antigen in nasopharyngeal carcinomaQ45740001
Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomasQ45744905
Role of enhanced radiosensitivity and the tumor-specific suicide gene vector in gene therapy of nasopharyngeal carcinomaQ45867639
Nasopharyngeal carcinoma in Chinese—Salted fish or inhaled smoke?Q46439618
Effects of basic fibroblast growth factor on protein kinase B activity and c-fos expression in CNE- I nasopharyngeal carcinoma cell lineQ46441826
Phosphatidylinositol 3-kinase regulates early differentiation in human laryngeal keratinocytesQ46608353
Inhibitors of epidermoid growth factor receptor suppress cell growth and enhance chemosensitivity of nasopharyngeal cancer cells in vitroQ46613450
Clinicopathologic significance of plasma matrix metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinomaQ47625748
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.Q47820459
BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating beta-catenin and ERK pathwaysQ48079928
Detection of c-myc gene expression in nasopharyngeal carcinoma by nonradioactive in situ hybridization and immunohistochemistry.Q50887618
Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling.Q51584737
Lack of correlation between G1 arrest and radiation age-response in three synchronized human tumour cell lines.Q52132973
Homozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma.Q52827239
The association between CD99 and LMP-1 expression in nasopharyngeal carcinoma.Q53347439
Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity.Q53390564
Expression of p16, nm23-H1, E-cadherin, and CD44 gene products and their significance in nasopharyngeal carcinoma.Q53395585
Identification of differentially expressed genes in nasopharyngeal carcinoma by means of the Atlas human cancer cDNA expression array.Q53407139
Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma.Q53431175
Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma.Q53435962
Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinomaQ53461208
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells.Q53541156
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancersQ55480673
Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancerQ57424487
The Detection of thec-mycandrasOncogenes in Nasopharyngeal Carcinoma by ImmunohistochemistryQ58068928
Ras-independent Activation of the Raf/MEK/ERK Pathway upon Calcium-induced Differentiation of KeratinocytesQ58181035
Nasopharyngeal carcinomaQ59344163
Detection of subclinical riasopharyngeal carcinoma by fibreoptic endoscopy and multiple biopsyQ59344294
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexesQ63407040
Epidermal growth factor receptor expression in human lung cancer cell linesQ69818833
Squamous cell carcinoma of the nasopharynx. An analysis of failure patterns after radiation therapyQ70099274
Growth factors and cancerQ70121988
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2Q70787131
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinomaQ71254205
Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissuesQ71327889
ras mutations are uncommon in nasopharyngeal carcinomaQ71362577
Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agentsQ71739769
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferationQ71833616
Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neckQ72571234
Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implicationsQ73006549
Thyroid cancerQ73412063
Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3Q73540287
Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-kappaB and AP-1Q73673875
Delineating genetic pathways of disease progression in head and neck squamous cell carcinomaQ73696172
Enhanced control by radiotherapy of cervical lymph node metastases arising from nasopharyngeal carcinoma compared with nodal metastases from other head and neck squamous cell carcinomasQ73705764
Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099Q74463750
Cell cycle control and cancerQ74678692
Reduced expression of p16 and p27 proteins in nasopharyngeal carcinomaQ77217463
[Expression of telomerase subunits and its relationship with telomerase activity in nasopharyngeal carcinoma]Q77541277
Prediction of occult neck metastases in laryngeal carcinoma: role of proliferating cell nuclear antigen, MIB-1, and E-cadherin immunohistochemical determinationQ77556339
Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosisQ77643702
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cellsQ77904111
Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridisationQ77995454
Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinomaQ78685119
Expression patterns of cyclins D1, E in laryngeal epithelial lesions: correlation with other cell cycle regulators (p53, pRb, Ki-67 and PCNA) and clinicopathological featuresQ80539313
P433issue7
P304page(s)946-963
P577publication date2008-07-01
P1433published inHead & NeckQ13703062
P1476titleNasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis
P478volume30

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Q93386603Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer
Q47877936MALAT1/miR-124/Capn4 axis regulates proliferation, invasion and EMT in nasopharyngeal carcinoma cells
Q40171125MYC and hsa‑miRNA‑423‑5p as biomarkers in nasopharyngeal carcinoma revealed by miRNA‑mRNA‑pathway network integrated analysis
Q58759078Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth
Q33654173Met degradation by SAIT301, a Met monoclonal antibody, reduces the invasion and migration of nasopharyngeal cancer cells via inhibition of EGR-1 expression
Q34708005MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma
Q38751308MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-κB signaling pathway
Q38841730MiR-145, a microRNA targeting ADAM17, inhibits the invasion and migration of nasopharyngeal carcinoma cells
Q52599797MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma.
Q34247536MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma
Q42723195MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
Q92839486MicroRNA-140 inhibits tumor progression in nasopharyngeal carcinoma by targeting CXCR4
Q38755853MicroRNA-15a Inhibits Proliferation and Induces Apoptosis in CNE1 Nasopharyngeal Carcinoma Cells
Q38811364MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN.
Q37402828Molecular Detection of Epstein - Barr virus in Nasopharyngeal Carcinoma among Sudanese population
Q35072994Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma
Q38385856Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079).
Q33598631NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation
Q92726867NKILA represses nasopharyngeal carcinoma carcinogenesis and metastasis by NF-κB pathway inhibition
Q37257200NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression
Q52628569Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches
Q47950153Nasopharyngeal Carcinoma: A 15 Year Study with Respect to Clinicodemography and Survival Analysis
Q37198074Nasopharyngeal cancer in Sudan: epidemiology, clinical and histological characteristics
Q42096715Nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers.
Q36262238Niflumic acid exhibits anti-tumor activity in nasopharyngeal carcinoma cells through affecting the expression of ERK1/2 and the activity of MMP2 and MMP9
Q38922626Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.
Q55286123Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors.
Q38656647Nutlin-3, A P53-Mdm2 Antagonist For Nasopharyngeal Carcinoma Treatment
Q90333146Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis
Q33864140Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma
Q44416846Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
Q35097767Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma
Q89456397Polymorphisms of CYP2E1 rs2031920 is not Associated with Risk of Nasopharyngeal Carcinoma in Minangkabau Ethnic Group
Q44833814Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs.
Q47155578Prognostic Value of Molecular Markers and Implication for Molecular Targeted Therapies in Nasopharyngeal Carcinoma: An Update in an Era of New Targeted Molecules Development
Q38133425Prognostic role of epidermal growth factor receptor in nasopharyngeal carcinoma: a meta-analysis
Q45751366Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma.
Q84066530Prognostic significance of galectin-3 and cyclin D1 expression in undifferentiated nasopharyngeal carcinoma
Q38600570Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: a systematic review and meta-analysis
Q64228155Protocadherin 17 is a tumor suppressor and is frequently methylated in nasopharyngeal carcinoma
Q38903947Protocadherin20 Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma
Q33594982Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma
Q42560502Quercetin-induced inhibition and synergistic activity with cisplatin - a chemotherapeutic strategy for nasopharyngeal carcinoma cells
Q59125738RGS17 inhibits tumorigenesis and improves 5-fluorouracil sensitivity in nasopharyngeal carcinoma
Q41173985Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy
Q39665370Resveratrol-induced p53-independent apoptosis of human nasopharyngeal carcinoma cells is correlated with the downregulation of ΔNp63
Q35080861Retracted: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
Q34286259Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a Western population
Q96576801S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1
Q35975562Salivary Anionic Changes after Radiotherapy for Nasopharyngeal Carcinoma: A 1-Year Prospective Study
Q38931451ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma
Q37260036Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC.
Q37697046Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
Q36327912Targeting Jab1/CSN5 in nasopharyngeal carcinoma
Q39025516Targeting nasopharyngeal carcinoma by artesunate through inhibiting Akt/mTOR and inducing oxidative stress
Q61447791Taxol-Resistant Gene 1 (Txr1) Mediates Oxaliplatin Resistance by Inducing Autophagy in Human Nasopharyngeal Carcinoma Cells
Q35851682The cadherin-catenin complex in laryngeal squamous cell carcinoma.
Q35145996The cadherin-catenin complex in nasopharyngeal carcinoma
Q39521568The expression of cyclin G in nasopharyngeal carcinoma and its significance
Q64946489The regulatory network of nasopharyngeal carcinoma metastasis with a focus on EBV, lncRNAs and miRNAs.
Q92218667Tissue P16 is Associated with Smoking Status among Indonesian Nasopharyngeal Carcinoma Subjects
Q38631755Tumor Suppressor p53 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1.
Q24299572Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties
Q35974869Upregulation of KLHDC4 Predicts a Poor Prognosis in Human Nasopharyngeal Carcinoma
Q39095740Using computational strategies to predict potential drugs for nasopharyngeal carcinoma
Q43205422WNT pathway in laryngeal squamous cell carcinoma and nasopharyngeal carcinoma.
Q36418335Whole blood transcriptome correlates with treatment response in nasopharyngeal carcinoma
Q39612057Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63.
Q37085002YPEL3 suppresses epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway
Q38701014lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma
Q42237944miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway by targeting Capn4.
Q33756203miR-18a downregulates DICER1 and promotes proliferation and metastasis of nasopharyngeal carcinoma
Q34299316miR-200a Regulates Epithelial-Mesenchymal to Stem-like Transition via ZEB2 and β-Catenin Signaling
Q36716288miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22
Q38796204β-Catenin is important for cancer stem cell generation and tumorigenic activity in nasopharyngeal carcinoma

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