PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase

scientific article published on 16 December 2013

PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.508515
P932PMC publication ID3916526
P698PubMed publication ID24344134

P2093author name stringYifan Chen
Wengong Wang
Xiaowei Zhang
Zhengyi Cao
Weibin Wang
Tanjun Tong
Shuya Wang
Ningguang Hu
P2860cites workNEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENQ24292919
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalizationQ24314543
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
SUMO-1 modification activates the transcriptional response of p53Q24529948
Transcription factor Sp3 is silenced through SUMO modification by PIAS1Q24534887
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membraneQ39328325
HuR knockdown changes the oncogenic potential of oral cancer cellsQ39724009
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathwayQ40198440
PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.Q40244068
c-Jun promotes cellular survival by suppression of PTEN.Q40283457
Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheliQ40328533
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.Q43621579
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signallingQ43848062
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levelsQ44350476
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
Expression profile of the putative catalytic subunit of the telomerase geneQ74251108
Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signalingQ77763832
Structure determination of the small ubiquitin-related modifier SUMO-1Q27760157
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.Q27863703
PTEN and myotubularin: novel phosphoinositide phosphatasesQ27937321
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
The nucleoporin RanBP2 has SUMO1 E3 ligase activityQ28115025
The polycomb protein Pc2 is a SUMO E3Q28115324
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.Q28117154
ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activationQ28140379
Involvement of PIAS1 in the sumoylation of tumor suppressor p53Q28189956
PIAS proteins: pleiotropic interactors associated with SUMOQ28248545
MMAC1/PTEN mutations in primary tumor specimens and tumor cell linesQ28256046
Ubch9 conjugates SUMO but not ubiquitinQ28257546
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activationQ28282094
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neuronsQ28506941
Pten is essential for embryonic development and tumour suppressionQ28509238
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
Regulation of PTEN transcription by p53Q28646911
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
SUMO--nonclassical ubiquitinQ29620234
A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometryQ30660638
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
SUMO, ubiquitin's mysterious cousinQ33939449
Modulation of STAT signaling by STAT-interacting proteinsQ33941428
Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activityQ35097655
Targeting the PI3K-Akt pathway in human cancer: rationale and promiseQ35571372
PIAS/SUMO: new partners in transcriptional regulation.Q35611422
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradationQ35939892
p53 sumoylation: mechanistic insights from reconstitution studiesQ36567469
New insights into PTEN.Q37011116
Detection of proteins sumoylated in vivo and in vitroQ37371314
WWP2 is an E3 ubiquitin ligase for PTEN.Q37588182
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3217-3230
P577publication date2013-12-16
P1433published inJournal of Biological ChemistryQ867727
P1476titlePIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase
P478volume289

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cites work (P2860)
Q51083539A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Q37066459HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis
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Q92906114Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions
Q45318299PTEN Regulation
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Q35380380Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications
Q42109613SENP1 regulates PTEN stability to dictate prostate cancer development.
Q64917488SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude.
Q36358151SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.
Q96639840SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites
Q34059285Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth
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Q91811364The significance of SUMOylation of angiogenic factors in cancer progression