A 39-bp deletion polymorphism in PTEN in African American individuals: implications for molecular diagnostic testing

scientific article published in May 2002

A 39-bp deletion polymorphism in PTEN in African American individuals: implications for molecular diagnostic testing is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1525-1578(10)60690-3
P932PMC publication ID1906990
P698PubMed publication ID11986403
P5875ResearchGate publication ID11384279

P50authorCharis EngQ37385393
P2093author name stringThomas W Prior
Heather Hampel
Nabil Saba
Xiao-Ping Zhou
Jennifer Roggenbuck
P2860cites workTEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Will the real Cowden syndrome please stand up: revised diagnostic criteriaQ24681567
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
A simple salting out procedure for extracting DNA from human nucleated cellsQ27861086
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer modelQ28202775
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathwaysQ31837554
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndromeQ34504165
Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin. Implications for microsatellite instability testingQ35787776
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosisQ40770781
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cellsQ40993616
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutationQ45345194
BRCA1 mutations in African AmericansQ46467295
Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombinationQ46508418
Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancerQ46701366
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromesQ57591248
A polymorphic stop codon in BRCA2Q71735471
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell deathQ73229813
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell deathQ73400418
P433issue2
P304page(s)114-117
P577publication date2002-05-01
P1433published inThe Journal of Molecular DiagnosticsQ7743603
P1476titleA 39-bp deletion polymorphism in PTEN in African American individuals: implications for molecular diagnostic testing
P478volume4

Reverse relations

cites work (P2860)
Q36594127An intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing
Q46440686Ossicular discontinuity and exostoses in Proteus syndrome: a case report

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