N-linked protein glycosylation in the endoplasmic reticulum

scientific article published on August 2013

N-linked protein glycosylation in the endoplasmic reticulum is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A013359
P932PMC publication ID3721281
P698PubMed publication ID23751184
P5875ResearchGate publication ID237095900

P50authorMarkus AebiQ1901356
P2093author name stringJörg Breitling
P2860cites workSimilarities and differences in the glycosylation mechanisms in prokaryotes and eukaryotesQ21328693
Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3Q22254184
Ribophorin I acts as a substrate-specific facilitator of N-glycosylationQ24294887
Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunitsQ24300202
Expression and characterization of a human cDNA ...Q24306138
DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphateQ24309978
Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoformsQ24321464
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorderQ24338882
Ribophorin I regulates substrate delivery to the oligosaccharyltransferase coreQ24647499
Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complexQ24652203
Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiencyQ27643961
Structure-guided identification of a new catalytic motif of oligosaccharyltransferaseQ27649167
X-ray structure of a bacterial oligosaccharyltransferaseQ27670457
Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiaeQ27930291
Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulumQ27930404
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathwayQ27930425
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesisQ27930476
The yeast SEC53 gene encodes phosphomannomutase.Q27930861
Cloning and expression in Escherichia coli of a yeast mannosyltransferase from the asparagine-linked glycosylation pathwayQ27931046
Saccharomyces cerevisiae sec59 cells are deficient in dolichol kinase activityQ27931351
The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulumQ27931362
The CWH8 gene encodes a dolichyl pyrophosphate phosphatase with a luminally oriented active site in the endoplasmic reticulum of Saccharomyces cerevisiaeQ27931459
Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiaeQ27931546
Subunits of the translocon interact with components of the oligosaccharyl transferase complexQ27931777
Ordered assembly of the asymmetrically branched lipid-linked oligosaccharide in the endoplasmic reticulum is ensured by the substrate specificity of the individual glycosyltransferasesQ27932071
New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locusQ27932427
Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeastQ27932866
Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylationQ27933465
PMI40, an intron-containing gene required for early steps in yeast mannosylationQ27934052
Does Rft1 flip an N-glycan lipid precursor?Q27934139
Genetic and Biochemical Characterization of the UGP1 Gene Encoding the UDP‐Glucose Pyrophosphorylase from Saccharomyces cerevisiaeQ27934217
Biosynthesis of lipid-linked oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc(2)-PP-dolicholQ27935145
Hetero-oligomeric interactions between early glycosyltransferases of the dolichol cycleQ27935164
The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylationQ27935362
ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesisQ27935927
Yeast oligosaccharyltransferase consists of two functionally distinct sub-complexes, specified by either the Ost3p or Ost6p subunitQ27936911
The Saccharomyces cerevisiae CWH8 gene is required for full levels of dolichol-linked oligosaccharides in the endoplasmic reticulum and for efficient N-glycosylationQ27936938
Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein.Q27937014
Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulumQ27938367
A family of hexosephosphate mutases in Saccharomyces cerevisiae.Q27938730
Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 proteinQ27938966
Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferaseQ27940341
Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiaeQ27940366
Allosteric regulation provides a molecular mechanism for preferential utilization of the fully assembled dolichol-linked oligosaccharide by the yeast oligosaccharyltransferaseQ28189668
Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membraneQ28267028
Enzymes of UDP-GlcNAc biosynthesis in yeastQ28291422
Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase.Q37070541
Oligosaccharyltransferase directly binds to ribosome at a location near the translocon-binding siteQ37182681
Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferasesQ37293056
The effect of individual N-glycans on enzyme activity.Q37414627
Targeted selection of recombinant clones through gene dosage effectsQ37510502
N-glycan structures: recognition and processing in the ER.Q37620688
Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylationQ37879988
Mechanisms and principles of N-linked protein glycosylationQ37943105
Diseases of glycosylation beyond classical congenital disorders of glycosylationQ37985356
Sulfhydryl modification of the yeast Wbp1p inhibits oligosaccharyl transferase activityQ38296852
Alg14 organizes the formation of a multiglycosyltransferase complex involved in initiation of lipid-linked oligosaccharide biosynthesisQ38330485
Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sitesQ38340035
Regulation of N-linked core glycosylation: use of a site-directed mutagenesis approach to identify Asn-Xaa-Ser/Thr sequons that are poor oligosaccharide acceptorsQ38346775
A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chainQ38360411
DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP).Q38419073
Distribution, metabolism and function of dolichol and polyprenolsQ39136434
Inhibitors of the Biosynthesis and Processing of N-Linked OligosaccharideQ40116930
Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidaseQ40644151
Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion proteinQ41985522
The role of the hydroxy amino acid in the triplet sequence Asn-Xaa-Thr(Ser) for the N-glycosylation step during glycoprotein biosynthesisQ41987279
An analysis of amino acid sequences surrounding archaeal glycoprotein sequonsQ42055149
Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turnsQ42129538
Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probesQ42140913
Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthaseQ42814343
Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints.Q43050786
Analysis of glycosylation site occupancy reveals a role for Ost3p and Ost6p in site-specific N-glycosylation efficiencyQ43416247
Substrate specificity of the glycosyl donor for oligosaccharyl transferaseQ43739157
Protein folding during cotranslational translocation in the endoplasmic reticulumQ44136466
Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferaseQ44180846
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.Q44446020
Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding.Q44599903
Functional reconstitution into proteoliposomes and partial purification of a rat liver ER transport system for a water-soluble analogue of mannosylphosphoryldolicholQ44925145
Identification of the Lipid Intermediate in Yeast Mannan BiosynthesisQ45012903
Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.Q46646842
Recycling of dolichyl monophosphate to the cytoplasmic leaflet of the endoplasmic reticulum after the cleavage of dolichyl pyrophosphate on the lumenal monolayerQ46852375
Manipulation of prenyl chain length determination mechanism of cis-prenyltransferasesQ46899576
Biases and complex patterns in the residues flanking protein N-glycosylation sitesQ47599654
The yeast oligosaccharyltransferase complex can be replaced by STT3 from Leishmania major.Q50456518
Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process.Q52114217
Glycoprotein biosynthesis in the alg3 Saccharomyces cerevisiae mutant. I. Role of glucose in the initial glycosylation of invertase in the endoplasmic reticulum.Q54238093
N-linked glycosylation of folded proteins by the bacterial oligosaccharyltransferase.Q54451855
Paramagnetic isoprenoid carrier lipids. 2. Dispersion and dynamics in lipid membranesQ57190704
Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineeringQ57381679
Effect of glucosylation of lipid intermediates on oligosaccharide transfer in solubilized microsomes from Saccharomyces cerevisiaeQ67246140
Biochemical and genetic studies on the function of, and relationship between, the PGI1- and CDC30-encoded phosphoglucose isomerases in Saccharomyces cerevisiaeQ67921497
The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residuesQ68010722
Characterization of the glycosylation sites in yeast external invertase. I. N-linked oligosaccharide content of the individual sequonsQ68137141
Characterization of the Saccharomyces cerevisiae cis-prenyltransferase required for dolichyl phosphate biosynthesisQ68217810
GlycoproteinsQ69213347
Transmembrane movement of oligosaccharide-lipids during glycoprotein synthesisQ71271140
Products of S cerevisiae cis-prenyltransferase activity in vitroQ71560877
Intracellular folding of tissue-type plasminogen activator. Effects of disulfide bond formation on N-linked glycosylation and secretionQ72591976
Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptorQ73580767
Glycosylation efficiency of Asn-Xaa-Thr sequons depends both on the distance from the C terminus and on the presence of a downstream transmembrane segmentQ73626593
Multiple dimeric forms of human CD69 result from differential addition of N-glycans to typical (Asn-X-Ser/Thr) and atypical (Asn-X-cys) glycosylation motifsQ73674638
The STT3 protein is a component of the yeast oligosaccharyltransferase complexQ74066319
Glycosylation of the overlapping sequons in yeast external invertase: effect of amino acid variation on site selectivity in vivo and in vitroQ77774621
Mapping the interaction of the STT3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chainsQ81334710
N-glycosylation at noncanonical Asn-X-Cys sequences in plant cellsQ82695215
Identification and characterization of a cDNA encoding a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cellsQ28588980
The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulumQ28610119
Oligosaccharyltransferase is highly specific for the hydroxy amino acid in Asn-Xaa-Thr/SerQ28610120
Amino acid sequence of human von Willebrand factorQ28630812
The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylationQ28941783
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
Glycosyltransferases: structures, functions, and mechanismsQ29617912
Effect of glycosylation on protein folding: a close look at thermodynamic stabilizationQ30157663
The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processingQ30836843
Transbilayer movement of Glc-P-dolichol and its function as a glucosyl donor: protein-mediated transport of a water-soluble analog into sealed ER vesicles from pig brainQ31951240
The yeast WBP1 is essential for oligosaccharyl transferase activity in vivo and in vitroQ32869546
Dolichol-linked oligosaccharide selection by the oligosaccharyltransferase in protist and fungal organismsQ33280867
The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferasesQ33745350
Stereoselective transbilayer translocation of mannosyl phosphoryl dolichol by an endoplasmic reticulum flippase.Q33953375
Molecular characterization of the cis-prenyltransferase of Giardia lambliaQ33979071
N-glycosylation efficiency is determined by the distance to the C-terminus and the amino acid preceding an Asn-Ser-Thr sequonQ34024744
The amino acid at the X position of an Asn-X-Ser sequon is an important determinant of N-linked core-glycosylation efficiency.Q34062516
Cotranslational folding and calnexin binding during glycoprotein synthesisQ34108450
N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coliQ34161971
The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and GolgQ34162106
Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic propertiesQ34218056
Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.Q34364461
The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeastQ34442428
An evolving view of the eukaryotic oligosaccharyltransferaseQ34471377
The dolichol pathway of N-linked glycosylationQ34486261
Protein glycosylation in yeast: transcript heterogeneity of the ALG7 geneQ34611615
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stabilityQ34940727
Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional alpha1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesisQ34961829
Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharidesQ35009876
Preferential transfer of the complete glycan is determined by the oligosaccharyltransferase complex and not by the catalytic subunitQ35075463
Antiribophorin antibodies inhibit the targeting to the ER membrane of ribosomes containing nascent secretory polypeptidesQ36223635
Transmembrane movement of a water-soluble analogue of mannosylphosphoryldolichol is mediated by an endoplasmic reticulum proteinQ36235867
The alpha subunit of the Saccharomyces cerevisiae oligosaccharyltransferase complex is essential for vegetative growth of yeast and is homologous to mammalian ribophorin I.Q36716409
Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursorQ36851292
All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiaeQ36854970
P433issue8
P921main subjectendoplasmic reticulumQ79927
glycosylationQ898365
P304page(s)a013359
P577publication date2013-08-01
P1433published inCold Spring Harbor Perspectives in BiologyQ3927509
P1476titleN-linked protein glycosylation in the endoplasmic reticulum
P478volume5

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