Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes

scientific article published on 6 January 2012

Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB11-0315
P932PMC publication ID3266398
P698PubMed publication ID22228718
P5875ResearchGate publication ID221732573

P2093author name stringRajiv Ratan
Sarah X Zhang
Yanming Chen
Joshua J Wang
Jingming Li
Yimin Zhong
P2860cites workGlutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cellsQ39906365
Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirusQ40394829
Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.Q40595070
Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetesQ41810320
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Pharmacokinetics and cerebrospinal fluid penetration of phenylacetate and phenylbutyrate in the nonhuman primateQ43629728
Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetesQ44686998
A central role for inflammation in the pathogenesis of diabetic retinopathyQ44961996
Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney diseaseQ46639000
Systemic and periocular deliveries of plasminogen kringle 5 reduce vascular leakage in rat models of oxygen-induced retinopathy and diabetesQ46658213
Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathyQ73013059
Müller cell changes in human diabetic retinopathyQ74371192
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanismQ24298728
ER stress and apoptosis: a new mechanism for retinal cell deathQ27690757
Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injuryQ28567043
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factorQ28567494
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Involvement of ER stress in retinal cell deathQ33282259
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivityQ33367128
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expressionQ33443692
Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4.Q33869840
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosisQ33958973
Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakageQ34082890
Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.Q34575640
From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importanceQ36203693
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivoQ36640055
ER stress and diseases.Q36731474
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathyQ37084522
Retinal ganglion cells in diabetesQ37195552
Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathyQ37214899
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter.Q37459881
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2Q37622629
Activation transcription factor-4 and the acute vascular response to injury.Q37715756
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.Q39737660
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
inflammationQ101991
hyperglycemiaQ271993
P304page(s)492-504
P577publication date2012-01-06
P1433published inDiabetesQ895262
P1476titleActivation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes
P478volume61

Reverse relations

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