Animal models of diabetic retinopathy: summary and comparison

scientific article published on 27 October 2013

Animal models of diabetic retinopathy: summary and comparison is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2013/106594
P932PMC publication ID3826427
P698PubMed publication ID24286086
P5875ResearchGate publication ID258959400

P2093author name stringAmy C Y Lo
Angela Ka Wai Lai
P2860cites workReduction of basement membrane thickening in diabetic cat retina by sulindacQ68738839
Studies on the retina of the diabetic db/db mouse. I. Endothelial cell-pericyte ratioQ69632257
Ocular pathology of diabetes mellitusQ70099993
Flat-Mount Studies of Human Retinal Vessels⋆Q71169874
Localization of vascular endothelial growth factor in human retina and choroidQ71226459
A mouse model of diabetic retinopathyQ71226463
Pathologic studies of the blood--retinal barrier in the spontaneously diabetic BB ratQ71275185
Oxygen-induced retinopathy in the mouseQ71608431
The BB Wistar rat: an experimental model for the study of diabetic retinopathyQ71773247
Diabetic retinopathy in a catQ71889695
Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularizationQ72120451
Galactose-induced retinal microangiopathy in ratsQ72512545
Diabeteslike proliferative retinal changes in galactose-fed dogsQ72624907
Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn ratQ72650581
Diabetes, a New Mutation in the MouseQ72798788
Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemiaQ73127991
Acarbose partially inhibits microvascular retinopathy in the Zucker Diabetic Fatty rat (ZDF/Gmi-fa)Q73279495
Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeabilityQ73347985
Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primatesQ73519344
Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulantQ73890660
Neuronal and microglial response in the retina of streptozotocin-induced diabetic ratsQ74052511
Anti-glycated albumin therapy ameliorates early retinal microvascular pathology in db/db miceQ74091486
Müller cell changes in human diabetic retinopathyQ74371192
Retinal vessel changes in galactose-fed dogsQ74696564
Lens and retinal changes in the WBN/Kob rat (spontaneously diabetic strain). Electron-microscopic studyQ74783677
Retinal hypoxia in long-term diabetic catsQ77072181
Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat.Q45926530
Early lipoic acid intake protects retina of diabetic miceQ46496432
The Ins2Akita mouse as a model of early retinal complications in diabetesQ46508398
Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic miceQ46564923
Retinal neovascularisation without ischaemia in the spontaneously diabetic Torii rat.Q46565438
Otsuka Long-Evans Tokushima fatty (OLETF) rat is not a suitable animal model for the study of angiopathic diabetic retinopathy.Q46611983
AT1 receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathyQ46622483
Early inner retinal dysfunction in streptozotocin-induced diabetic ratsQ46638013
Electroretinographic study of spontaneously diabetic Torii ratsQ46699203
Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.Q46774689
Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.Q46774822
ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetesQ46782071
Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetesQ46782102
CR-6 protects glutathione peroxidase activity in experimental diabetesQ46928558
Preventive effects of North American ginseng (Panax quinquefolius) on diabetic retinopathy and cardiomyopathy.Q47795728
Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampusQ48485776
Early-stage retinal melatonin synthesis impairment in streptozotocin-induced diabetic wistar rats.Q48913574
Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemiaQ49107478
Pharmacological evidence for the presence of functional beta(3)-adrenoceptors in rat retinal blood vessels.Q39935043
Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005-2050.Q40020452
Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetesQ40666660
(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammationQ41275103
Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degenerationQ41506713
Vitreous IGFBP-3 effects on Müller cell proliferation and tractional force generationQ41998096
Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouseQ42141781
Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathwayQ42142207
Characterization of diabetic microaneurysms by simultaneous fluorescein angiography and spectral-domain optical coherence tomographyQ42177020
Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathyQ42177617
Attenuation of streptozotocin-induced microvascular changes in the mouse retina with the endothelin receptor A antagonist atrasentanQ42400411
Ocular structure and function in an aged monkey with spontaneous diabetes mellitusQ42472911
TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterationsQ42592010
Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes.Q42703600
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatmentQ42722726
Roles of AMP-activated protein kinase in diabetes-induced retinal inflammationQ42725397
Protective effects of rosiglitazone on retinal neuronal damage in diabetic ratsQ42733746
Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathyQ42756254
Inhibition of 20-HETE attenuates diabetes-induced decreases in retinal hemodynamicsQ42824768
Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.Q42854405
Simvastatin suppresses expression of angiogenic factors in the retinas of rats with streptozotocin-induced diabetesQ42915712
Effect of an intravitreal injection of bevacizumab on the expression of VEGF and CD34 in the retina of diabetic ratsQ42960882
Application of isoproterenol inhibits diabetic-like changes in the rat retinaQ43056643
ERK1/2 signaling pathways involved in VEGF release in diabetic rat retinaQ43072986
Amelioration of diabetic retinopathy by engrafted human adipose-derived mesenchymal stem cells in streptozotocin diabetic ratsQ43076549
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafishQ43119674
Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathyQ43160577
Retinal heparanase expression in streptozotocin-induced diabetic ratsQ43174398
The role of CTGF in the diabetic rat retina and its relationship with VEGF and TGF-β(2) , elucidated by treatment with CTGFsiRNA.Q43205603
Diabetic retinopathy and choroidal angiopathy in diabetic rats (WBN/Kob).Q43246152
Retinal localization of the glutamate receptor GluR2 and GluR2-regulating proteins in diabetic ratsQ43251567
Protective effect of clusterin on blood-retinal barrier breakdown in diabetic retinopathyQ43252211
Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats.Q43277606
Inhibition of vitreoretinal VEGF elevation and blood-retinal barrier breakdown in streptozotocin-induced diabetic rats by brimonidineQ43285278
Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinasQ43442634
Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbitQ43637135
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathyQ43687875
Reduction of experimental diabetic vascular leakage and pericyte apoptosis in mice by delivery of αA-crystallin with a recombinant adenovirusQ43746368
Early retinal damage in experimental diabetes: electroretinographical and morphological observationsQ44036075
Retinal and choroidal vasculature in rats with spontaneous diabetes type 2 treated with the angiotensin-converting enzyme inhibitor cilazapril: corrosion cast and electron-microscopic studyQ44151639
Differential retinal angiogenic response to sustained intravitreal release of VEGF and bFGF in different pigmented rabbit breedsQ44153453
Retinal capillary basement membrane thickening in a porcine model of diabetes mellitus.Q44286128
Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retinaQ44536369
Neuro-optic cell apoptosis and microangiopathy in KKAY mouse retinaQ44679483
Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogsQ44684820
Oscillatory potential analysis and ERGs of normal and diabetic ratsQ44777411
A central role for inflammation in the pathogenesis of diabetic retinopathyQ44961996
Expression of apoptosis markers in the retinas of human subjects with diabetesQ44995675
Death of retinal neurons in streptozotocin-induced diabetic miceQ45028039
Retinopathy in monkeys with spontaneous type 2 diabetesQ45158806
Retinal heat shock protein 25 in early experimental diabetesQ45242791
Vasoinhibin gene transfer by adenoassociated virus type 2 protects against VEGF- and diabetes-induced retinal vasopermeability.Q45362426
Effects of sulfinpyrazone on retinal damage induced by experimental diabetes mellitus in rabbitsQ77167155
Rod photoreceptors in infant rats with a history of oxygen exposureQ77794494
Vascular architecture of degenerated retina in WBN/Kob rats: corrosion cast and electron microscopic studyQ78040481
Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitusQ78040840
Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularizationQ79143886
Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinasQ79786378
Age-dependent retinal capillary pericyte degeneration in galactose-fed dogsQ79885693
Changes of oscillatory potentials and photopic negative response in patients with early diabetic retinopathyQ80081032
Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dogQ80183167
Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetesQ80510725
Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathyQ82835101
Characteristics of diabetic retinopathy in SDT ratsQ83008636
The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus childrenQ83333485
Intraocular expression of thymosin β4 in proliferative diabetic retinopathyQ83438873
Blockade of early and late retinal biochemical alterations associated with diabetes development by the selective bradykinin B1 receptor antagonist R-954Q83522274
New insights into the pathoanatomy of diabetic macular edema: angiographic patterns and optical coherence tomographyQ83823286
Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusionQ84020816
Diabetic retinopathyQ84482290
Wld(S) protects against peripheral neuropathy and retinopathy in an experimental model of diabetes in miceQ84523226
Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic ratsQ84838870
Effect of lipoic acid on expression of angiogenic factors in diabetic rat retinaQ84916768
Tacrolimus (FK506) prevents early retinal neovascularization in streptozotocin-induced diabetic miceQ87405328
The BB-rat--an authentic model of human diabetic retinopathyQ93646191
Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitorQ39554740
Retinal vascular calibre as a predictor of incidence and progression of diabetic retinopathyQ39638361
Selective loss of vascular smooth muscle cells in the retinal microcirculation of diabetic dogsQ39698638
Strain-dependent differences in oxygen-induced retinopathy in the inbred rat.Q39711866
Diabetic retinopathy: morphometric analysis of basement membrane thickening of capillaries in different retinal layers within arterial and venous environmentsQ39714430
Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia.Q39727356
The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurityQ39756440
Genetic Influence of the Streptozotocin-induced Insulitis and HyperglycemiaQ39828041
Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathyQ39901974
Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivoQ39918429
A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusionQ39929242
Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemiaQ27320203
Breeding of a non-obese, diabetic strain of miceQ28276534
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathyQ28576755
Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory responseQ28577183
Expression and cellular localization of microRNA-29b and RAX, an activator of the RNA-dependent protein kinase (PKR), in the retina of streptozotocin-induced diabetic ratsQ28577524
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetesQ28584295
Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugsQ30010106
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathyQ30393975
Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetesQ30492552
Subclinical capillary changes in non-proliferative diabetic retinopathy.Q30514002
Retinal capillary changes in Otsuka Long-Evans Tokushima fatty rats (spontaneously diabetic strain). Electron-microscopic studyQ30742058
Retinal changes in Otsuka long-evans Tokushima Fatty rats (spontaneously diabetic rat)--possibility of a new experimental model for diabetic retinopathyQ30886777
In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic ratsQ32006453
Endothelin antagonism prevents diabetic retinopathy in NOD mice: a potential role of the angiogenic factor adrenomedullin.Q33245457
Microglial changes occur without neural cell death in diabetic retinopathyQ33271223
Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic ratsQ33283145
Development of a new mouse model of branch retinal vein occlusion and retinal neovascularizationQ33292156
Neuronal and glial cell changes are determined by retinal vascularization in retinopathy of prematurityQ33292414
Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegenerationQ33294402
Genetic determinants of hyaloid and retinal vasculature in zebrafishQ33302704
Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathyQ33354053
Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activationQ33360791
Apolipoprotein A1 is overexpressed in the retina of diabetic patients.Q33375239
Animal models of choroidal and retinal neovascularizationQ33582933
Transcriptomic comparison of the retina in two mouse models of diabetesQ33631458
Longitudinal in vivo imaging of retinal gliosis in a diabetic mouse modelQ33639461
Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and ratsQ33665353
Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetesQ33773287
Quantitative analysis of pupillary light reflex by real-time autofluorescent imaging in a diabetic mouse modelQ33805646
Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve functionQ33845105
Pathophysiological characteristics of diabetic ocular complications in spontaneously diabetic torii ratQ33873906
Profile of lipid and protein autacoids in diabetic vitreous correlates with the progression of diabetic retinopathyQ33930304
Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway.Q33930328
Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic miceQ33994233
Effect of antioxidant N-acetylcysteine on diabetic retinopathy and expression of VEGF and ICAM-1 from retinal blood vessels of diabetic ratsQ34033023
Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retinaQ34081271
Comparison of three strains of diabetic rats with respect to the rate at which retinopathy and tactile allodynia developQ34081378
Microangiopathic retinopathy in experimental diabetic monkeysQ34165332
VEGF expression and cell apoptosis in NOD mouse retinaQ34254508
Characterization of a Mouse Model of Hyperglycemia and Retinal NeovascularizationQ34254645
Glucose intolerance in teleost fish: fact or fiction?Q34278111
The effects of aminoguanidine on retinopathy in STZ-induced diabetic ratsQ34280920
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation.Q34296553
High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier functionQ34355294
High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins.Q34355326
Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway.Q34493861
Diabetic eNOS-knockout mice develop accelerated retinopathy.Q34735429
Ultrastructural features of retinal capillary basement membrane thickening in diabetic swineQ34898389
The zebrafish as a tool for understanding the biology of visual disordersQ35043686
Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat modelQ50436532
Proliferative vitreoretinopathy in the Swine-a new model.Q50494678
Glial reactivity, an early feature of diabetic retinopathy.Q50511477
Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation.Q50514993
Hypoxia-induced retinopathy model in adult zebrafish.Q50532574
Effect of tempol on diabetes-induced decreases in retinal blood flow in the mouse.Q50539855
Microvascular retinopathy in the Zucker diabetic fatty rat.Q51052202
Inflammatory and angiogenic factors in the aqueous humor and the relationship to diabetic retinopathy.Q51628940
Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor.Q52483097
Diabetes impairs the neuroprotective properties of retinal alpha-crystallins.Q52609718
Nonmydriatic ultrawide field retinal imaging compared with dilated standard 7-field 35-mm photography and retinal specialist examination for evaluation of diabetic retinopathy.Q53160082
Impaired glucose tolerance plus hyperlipidaemia induced by diet promotes retina microaneurysms in New Zealand rabbits.Q53272014
Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats.Q54330349
Two isoforms of Flk-1 transcripts in early diabetic rat retinas.Q54336760
Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss.Q54337640
Increased expression of αA-crystallin in human diabetic eye.Q54369158
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietinQ54405122
Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy.Q54494445
Generation of trans-arachidonic acid under nitrative stress is associated with upregulation of thromponsdin-1 in diabetic rats.Q54575585
Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanismsQ57840010
Characterization of retinal function and glial cell response in a mouse model of oxygen-induced retinopathyQ59464509
Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic RetinopathyQ59621017
Induction of hyperglycaemia in zebrafish (Danio rerio) leads to morphological changes in the retinaQ61820579
Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathyQ62019449
Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse modelQ62066203
Development of diabetic complications in a new diabetic strain of rat (WBN/Kob)Q68029509
Retinal redox stress and remodeling in cardiometabolic syndrome and diabetesQ35157994
The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal modelsQ35180049
Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic ratsQ35195608
The influence of alloxan-induced diabetes on Müller cell contraction-promoting activities in vitreousQ35247664
Intervention with an erythropoietin-derived peptide protects against neuroglial and vascular degeneration during diabetic retinopathyQ35405149
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakageQ35600275
Aminoguanidine reverses the loss of functional hyperemia in a rat model of diabetic retinopathyQ35661653
Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivoQ35719498
Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathyQ35791559
TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathyQ35855616
Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy.Q35891554
Decrease in retinal neuronal cells in streptozotocin-induced diabetic mice.Q36015795
Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell deathQ36338100
Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathyQ36571714
A multifocal electroretinogram model predicting the development of diabetic retinopathyQ36584270
Ozagrel attenuates early streptozotocin-induced constriction of arterioles in the mouse retinaQ36646301
Applying transgenic zebrafish technology to study the retina.Q36717110
Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathyQ36717869
Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic miceQ36744052
A new spontaneously diabetic non-obese Torii rat strain with severe ocular complicationsQ36781103
Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes.Q36796104
Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retinaQ36807663
Attenuation of diabetes-induced retinal vasoconstriction by a thromboxane receptor antagonistQ37096956
Type 1 diabetes in the BB rat: a polygenic diseaseQ37141760
Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulinQ37384532
Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy.Q37418982
Rates of progression in diabetic retinopathy during different time periods: a systematic review and meta-analysisQ37437199
The parameters of the porcine eyeballQ37834453
The diversity of sex steroid action: regulation of metabolism by estrogen signalingQ37867854
Digital ocular fundus imaging: a reviewQ37939563
Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetesQ38294227
Increase in retinal hypoxia-inducible factor-2α, but not hypoxia, early in the progression of diabetes in the rat.Q38585336
Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathyQ38914306
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathyQ38937447
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdiabetic retinopathyQ631361
animal disease modelQ64732998
biomedical investigative techniqueQ66648976
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)106594
P577publication date2013-10-27
P1433published inJournal of Diabetes ResearchQ26841822
P1476titleAnimal models of diabetic retinopathy: summary and comparison
P478volume2013

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cites work (P2860)
Q59796439A Contrast in Pathogenic Responses between C57BL/6J and BALB/cJ Mice Using a Model of Retinal Injury
Q90679887Adult Goat Retinal Neuronal Culture: Applications in Modeling Hyperglycemia
Q39455385Animal models of ocular angiogenesis: from development to pathologies
Q38715502Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents
Q26766504Brain and Retinal Pericytes: Origin, Function and Role
Q40543143Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Q42067217Can allopurinol improve retinopathy in diabetic rats? Oxidative stress or uric acid; which one is the culprit?
Q35717962Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy
Q34564352Choosing preclinical study models of diabetic retinopathy: key problems for consideration
Q35974023Compromised Wound Healing in Ischemic Type 2 Diabetic Rats
Q36102156Consumption of Polyphenol-Rich Zingiber Zerumbet Rhizome Extracts Protects against the Breakdown of the Blood-Retinal Barrier and Retinal Inflammation Induced by Diabetes
Q92003034Detailed Evaluation of Possible Ganglion Cell Loss in the Retina of Zucker Diabetic Fatty (ZDF) Rats
Q42388898Development of diabetes-induced acidosis in the rat retina
Q49724247Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System.
Q26765466Diabetic Retinopathy: Animal Models, Therapies, and Perspectives
Q48169124Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes
Q36281488FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice
Q28546854FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy
Q51746813Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice.
Q41483514Histological Evaluation of Diabetic Neurodegeneration in the Retina of Zucker Diabetic Fatty (ZDF) Rats
Q91081552Human blood vessel organoids as a model of diabetic vasculopathy
Q47596081Hyperglycemia Alters the Protein Levels of Prominin-1 and VEGFA in the Retina of Albino Rats
Q37538552IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling
Q40377263Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing
Q51708546Inhibition of HIF-1α decreases expression of pro-inflammatory IL-6 and TNF-α in diabetic retinopathy.
Q41829980Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats
Q41902127Intravitreal injection of ranibizumab and CTGF shRNA improves retinal gene expression and microvessel ultrastructure in a rodent model of diabetes
Q41992574Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects
Q57183608Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets
Q36155334Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model
Q33845094NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence
Q38258984Natural product inhibitors of ocular angiogenesis
Q60647753Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
Q100633580Noninvasive temporal detection of early retinal vascular changes during diabetes
Q39627126Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice
Q54956368Ocular findings in Zucker Diabetic Fatty rats emphasize the key role of neuroglia degeneration in diabetic retinopathy pathophysiology.
Q50234493Ocular lesions in leptin receptor-deficient medaka (Oryzias latipes).
Q64245243Pancreatic kallikrein protects against diabetic retinopathy in KK Cg-A/J and high-fat diet/streptozotocin-induced mouse models of type 2 diabetes
Q41261736Perivascular Progenitor Cells Derived From Human Embryonic Stem Cells Exhibit Functional Characteristics of Pericytes and Improve the Retinal Vasculature in a Rodent Model of Diabetic Retinopathy
Q58578901Prostaglandin E/EP receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes
Q36051751Retinal Electrophysiological Effects of Intravitreal Bone Marrow Derived Mesenchymal Stem Cells in Streptozotocin Induced Diabetic Rats
Q38828260Review: adiponectin in retinopathy.
Q37729999Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4.
Q48623673Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.
Q48099937Study of retinal neurodegeneration and maculopathy in diabetic Meriones shawi: A particular animal model with human-like macula.
Q49827430Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature
Q89849546Targeting long non-coding RNA MALAT1 alleviates retinal neurodegeneration in diabetic mice
Q48215353Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina
Q55398453The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse Model.
Q51430597The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown.
Q26852080The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding
Q38719213Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice
Q55327262Young Ossabaw Pigs Fed a Western Diet Exhibit Early Signs of Diabetic Retinopathy.
Q37202605Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats

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