| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Jacey Hongjie Ma | Q96232804 |
| P2093 | author name string | Josh J Wang | |
| Sarah X Zhang | |||
| P2860 | cites work | Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress | Q22010800 |
| XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 | ||
| ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs | Q24290776 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development | Q24292104 | ||
| Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response | Q24292966 | ||
| The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism | Q24298728 | ||
| XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation | Q24304996 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis | Q24337309 | ||
| Endoplasmic reticulum stress and the inflammatory basis of metabolic disease | Q24633352 | ||
| Unfolded protein response in a Drosophila model for retinal degeneration | Q24682908 | ||
| Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. | Q40714649 | ||
| Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. | Q41087457 | ||
| Increased expression of IRE1alpha and stress-related signal transduction proteins in ischemia-reperfusion injured retina | Q41281126 | ||
| Toll-like receptor 3 and geographic atrophy in age-related macular degeneration | Q41888443 | ||
| Significance of outer blood-retina barrier breakdown in diabetes and ischemia | Q41924777 | ||
| ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress | Q42518206 | ||
| Regulation of extracellular-superoxide dismutase in rat retina pericytes | Q42761451 | ||
| Autophagy--hot topic in AMD. | Q43114669 | ||
| Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. | Q43116152 | ||
| Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma model | Q43255779 | ||
| Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy | Q43442147 | ||
| Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells | Q44987182 | ||
| Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. | Q45345766 | ||
| Autophagy, exosomes and drusen formation in age-related macular degeneration | Q46095511 | ||
| The role of autophagy in pancreatic beta-cell and diabetes. | Q46154042 | ||
| Prevalence of diabetic retinopathy in urban India: the Chennai Urban Rural Epidemiology Study (CURES) eye study, I. | Q46568353 | ||
| Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. | Q46742618 | ||
| Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes. | Q46774822 | ||
| Causes and prevalence of visual impairment among adults in the United States | Q46890945 | ||
| [Changes of tight junction protein and GFAP in the retina of experimental diabetic rats and their relationship with blood aqueous barrier]. | Q50465940 | ||
| In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis | Q52224944 | ||
| XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress. | Q53676823 | ||
| Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway. | Q54515304 | ||
| Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas. | Q54573507 | ||
| Diabetic Retinopathy | Q57232741 | ||
| XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy | Q60613336 | ||
| A permeability defect of the retinal pigment epithelium. Occurrence in early streptozocin diabetes | Q70524670 | ||
| Results of 20 years of research on the treatment of diabetic retinopathy | Q72521113 | ||
| A time-dependent phase shift in the mammalian unfolded protein response | Q72997174 | ||
| Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation | Q79369985 | ||
| Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 | Q80979487 | ||
| SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation | Q83523700 | ||
| The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy | Q84927447 | ||
| ER stress and apoptosis: a new mechanism for retinal cell death | Q27690757 | ||
| Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
| A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter | Q28119099 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation | Q28296585 | ||
| Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells | Q28485361 | ||
| CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | Q28512249 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
| Cloning of mammalian Ire1 reveals diversity in the ER stress responses | Q28587224 | ||
| ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery | Q28587463 | ||
| An essential role in liver development for transcription factor XBP-1 | Q28593777 | ||
| ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response | Q28611502 | ||
| The unfolded protein response: from stress pathway to homeostatic regulation | Q29547396 | ||
| An integrated stress response regulates amino acid metabolism and resistance to oxidative stress | Q29547441 | ||
| IRE1 signaling affects cell fate during the unfolded protein response | Q29615502 | ||
| Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes | Q29615503 | ||
| IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030 | Q29620059 | ||
| Immunohistochemical localization of blood-retinal barrier breakdown in human diabetics | Q30444967 | ||
| Paneth cells as a site of origin for intestinal inflammation. | Q30559414 | ||
| Involvement of ER stress in retinal cell death | Q33282259 | ||
| Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage | Q33291720 | ||
| Endoplasmic reticulum stress and diabetic retinopathy | Q33352111 | ||
| Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication | Q33409407 | ||
| Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases | Q33517638 | ||
| Transcriptional regulation of VEGF-A by the unfolded protein response pathway | Q33539754 | ||
| An essential role for XBP-1 in host protection against immune activation in C. elegans | Q33710158 | ||
| Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience ( | Q33835519 | ||
| Molecular mechanisms of vascular permeability in diabetic retinopathy | Q33887339 | ||
| Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine | Q34103511 | ||
| Retinal Muller glia initiate innate response to infectious stimuli via toll-like receptor signaling | Q34130684 | ||
| Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis | Q34169287 | ||
| Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury. | Q34208396 | ||
| The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes. | Q34224697 | ||
| In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles | Q37394440 | ||
| Recent developments in the treatment of age-related macular degeneration | Q37679956 | ||
| Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. | Q37715801 | ||
| Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds | Q38288841 | ||
| Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes | Q38294227 | ||
| cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters. | Q38339202 | ||
| Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. | Q39356067 | ||
| Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. | Q39493020 | ||
| Preventing oxidative stress: a new role for XBP1. | Q39879215 | ||
| The prevalence of diabetic retinopathy among adults in the United States | Q40517905 | ||
| Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response | Q40590374 | ||
| Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. | Q40595070 | ||
| Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes | Q40666660 | ||
| SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway | Q34287569 | ||
| X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium | Q34310315 | ||
| Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway. | Q34493861 | ||
| Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1. | Q34575640 | ||
| Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. | Q34581539 | ||
| Suppression of XBP1S mediates high glucose-induced oxidative stress and extracellular matrix synthesis in renal mesangial cell and kidney of diabetic rats | Q34606527 | ||
| Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization | Q34749337 | ||
| TLR2 mediates the innate response of retinal Muller glia to Staphylococcus aureus | Q35032361 | ||
| TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. | Q35041384 | ||
| Alcohol abuse, endoplasmic reticulum stress and pancreatitis | Q35537182 | ||
| The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. | Q35551757 | ||
| Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytes | Q35627455 | ||
| Regulatory role of TLR ligands on the activation of autoreactive T cells by retinal astrocytes | Q35733820 | ||
| Oxidative stress and diabetic retinopathy | Q35819297 | ||
| TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy | Q35855616 | ||
| Glial and neuronal dysfunction in streptozotocin-induced diabetic rats | Q35928449 | ||
| BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. | Q36000128 | ||
| Toll-like receptor 2 ligand pretreatment attenuates retinal microglial inflammatory response but enhances phagocytic activity toward Staphylococcus aureus | Q36018242 | ||
| Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy? | Q36020366 | ||
| ER stress is involved in T17M rhodopsin-induced retinal degeneration. | Q36077630 | ||
| Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes | Q36080882 | ||
| Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells | Q36089271 | ||
| Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes | Q36144061 | ||
| Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death | Q36176234 | ||
| ER stress inhibits neuronal death by promoting autophagy | Q36187772 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| Quinotrierixin inhibits proliferation of human retinal pigment epithelial cells | Q36521062 | ||
| Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy | Q36639215 | ||
| P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro. | Q36724620 | ||
| Regulation of retinal blood flow in health and disease. | Q37151548 | ||
| Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow | Q37176759 | ||
| ER stress protects from retinal degeneration | Q37194635 | ||
| Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy | Q37214899 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endoplasmic reticulum unfolded protein response | Q14633900 |
| retina | Q169342 | ||
| diabetic retinopathy | Q631361 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 160140 | |
| P577 | publication date | 2014-01-01 | |
| 2014-10-29 | |||
| P1433 | published in | Journal of Diabetes Research | Q26841822 |
| P1476 | title | The unfolded protein response and diabetic retinopathy | |
| P478 | volume | 2014 |
| Q92370282 | Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells |
| Q88869497 | ER stress and unfolded protein response in ocular health and disease |
| Q58567751 | Glucose-regulated protein 78 in the aqueous humor in diabetic macular edema patients |
| Q38713406 | High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. |
| Q93048565 | Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes |
| Q30389325 | Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction. |
| Q88872304 | Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice |
| Q41633837 | Nuclear factor-kappa B1 inhibits early apoptosis of glioma cells by promoting the expression of Bcl-2 |
| Q55031516 | Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases. |
| Q52731094 | Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy. |
| Q37319994 | The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions |
| Q41521844 | The neuroprotective potential of endoplasmic reticulum chaperones |
| Q26852080 | The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding |
| Q58702700 | The unfolded protein response signaling and retinal Müller cell metabolism |
| Q36372969 | Unfolded protein response is activated in aged retinas |
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