Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death

scientific article

Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2012.05.005
P932PMC publication ID3423192
P698PubMed publication ID22609432

P2093author name stringChristopher C Glembotski
Donna J Thuerauf
John A Vekich
Peter J Belmont
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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein responseQ28611502
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene inductionQ28854565
Large-scale analysis of the human and mouse transcriptomesQ29547360
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
A C-terminal signal prevents secretion of luminal ER proteinsQ29618994
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The protein disulphide-isomerase family: unravelling a string of foldsQ33543247
A plasma membrane wound proteome: reversible externalization of intracellular proteins following reparable mechanical damageQ33681733
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.Q34120076
The glucose-regulated proteins: stress induction and clinical applicationsQ34336908
Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formationQ34608269
Substrate recognition by the protein disulfide isomerasesQ34692501
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heartQ34809985
Activation of endoplasmic reticulum stress response during the development of ischemic heart diseaseQ35047817
The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic loadQ35105380
Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomeraseQ35286858
Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heartQ35898986
From acute ER stress to physiological roles of the Unfolded Protein ResponseQ36362397
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-IQ36747593
Endoplasmic reticulum stress in the heartQ36996959
Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heartQ37353324
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress responseQ37447782
A structural overview of the PDI family of proteinsQ37783329
Multiple ways to make disulfidesQ37903530
Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible geneQ38291406
Proteins upregulated by mild and severe hypoxia in squamous cell carcinomas in vitro identified by proteomics.Q39835563
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.Q40134133
Identification of protein disulfide isomerase as a cardiomyocyte survival factor in ischemic cardiomyopathyQ40176298
p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model systemQ41732350
PHLPP-1 negatively regulates Akt activity and survival in the heartQ41809036
The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulumQ44230446
Biochemical characterization of the 94- and 78-kilodalton glucose-regulated proteins in hamster fibroblastsQ44576917
The role of PDI as a survival factor in cardiomyocyte ischemiaQ44962719
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viabilityQ45101812
Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survivalQ45152588
Characterization and purification of the 94-kDa glucose-regulated proteinQ46388990
Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblastsQ46655391
Evidence for mitochondrial localization of P5, a member of the protein disulphide isomerase familyQ47761852
Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signalQ56766292
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytesQ64377708
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Q80979487
Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6Q83118076
P433issue2
P921main subjectcell deathQ2383867
P304page(s)259-267
P577publication date2012-05-17
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleProtein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death
P478volume53

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