The transcription factor X-box binding protein-1 in neurodegenerative diseases

scientific article published on 12 September 2014

The transcription factor X-box binding protein-1 in neurodegenerative diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1048097684
P356DOI10.1186/1750-1326-9-35
P932PMC publication ID4166022
P698PubMed publication ID25216759
P5875ResearchGate publication ID265607272

P50authorEric DuplanQ38321066
Frédéric CheclerQ38321085
P2093author name stringJulie Dunys
P2860cites workXBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligaseQ22254584
Plasma cell differentiation requires the transcription factor XBP-1Q24291453
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein responseQ24305069
Protective effect against Parkinson's disease-related insults through the activation of XBP1Q24314837
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
The ER stress factor XBP1s prevents amyloid-beta neurotoxicityQ24598012
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagyQ24655821
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseaseQ28116512
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein responseQ28139601
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegenerationQ28242222
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1Q28509073
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocationQ28510062
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein responseQ28589998
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Regulation of glucose homeostasis through a XBP-1-FoxO1 interactionQ28592129
An essential role in liver development for transcription factor XBP-1Q28593777
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 miceQ30494698
Identification of an expanded CAG repeat in the Huntington's disease gene (IT15) in a family reported to have benign hereditary choreaQ33596088
The cellular response to protein misfolding in the endoplasmic reticulum.Q33706901
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy fluxQ34033567
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.Q34189618
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein responseQ35170906
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagyQ35909430
XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.Q53676823
Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice.Q54328614
Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.Q54447692
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivoQ83323941
The other sweet face of XBP-1Q83557676
Differential activation of the ER stress factor XBP1 by oligomeric assembliesQ36070065
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cellsQ36739979
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampusQ37164517
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Activation and clinical significance of the unfolded protein response in breast cancerQ37424111
The role of X-box binding protein-1 in tumorigenicity.Q37553966
p53 in neurodegenerative diseases and brain cancersQ38167220
Lipid landscapes and pipelines in membrane homeostasisQ38217765
Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly bindsQ38288841
Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stageQ38322371
IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1.Q38347956
Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas.Q38433525
Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancersQ38449959
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survivalQ38996766
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.Q39069488
ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.Q39187400
TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytesQ39306114
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generationQ39726471
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.Q40254780
Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's diseaseQ40414917
The natural history of motoneuron loss in amyotrophic lateral sclerosisQ41434654
Splicing: HACking into the unfolded-protein responseQ41720776
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicityQ42042260
Polymorphism -116C/G of human X-box-binding protein 1 promoter is associated with risk of Alzheimer's diseaseQ43574936
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.Q44251931
CAG repeat size and clinical presentation in Huntington's diseaseQ45290140
AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's diseaseQ45306832
Activation of the unfolded protein response in Parkinson's diseaseQ48297659
The unfolded protein response is activated in Alzheimer's disease.Q48839954
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecttranscription factorQ407384
regulation of gene expressionQ411391
neurodegenerationQ1755122
DNA-binding proteinQ2252764
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)35
P577publication date2014-09-12
P1433published inMolecular NeurodegenerationQ15817329
P1476titleThe transcription factor X-box binding protein-1 in neurodegenerative diseases
P478volume9

Reverse relations

cites work (P2860)
Q47831348Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.
Q47596098Are sigma receptor modulators a weapon against multiple sclerosis disease?
Q48211267Association of the AURKA and AURKC gene polymorphisms with an increased risk of gastric cancer
Q42053390Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1.
Q27022552Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress
Q47098483Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer
Q38713406High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress.
Q38463463Molecular mechanisms of diabetic retinopathy: potential therapeutic targets
Q88442029Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease
Q90435275Rotavirus Infection Alters Splicing of the Stress-Related Transcription Factor XBP1
Q36887309The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.
Q41828232The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease

Search more.