Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.

scientific article published on 29 January 2018

Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment. is …
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scholarly articleQ13442814

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P356DOI10.3390/PH11010012
P8608Fatcat IDrelease_ic2l3c5zgrd6vdtzynfsr7pjcq
P932PMC publication ID5874708
P698PubMed publication ID29382156

P50authorMarcia Regina CominettiQ42842705
Patricia R ManzineQ57057789
Rafaela PeronQ92674090
Antoni CaminsQ38639318
P2093author name stringIzabela Pereira Vatanabe
P2860cites workAPP binds DR6 to trigger axon pruning and neuron death via distinct caspasesQ22251088
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expressionQ24300299
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammalsQ24301578
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Q24601406
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagyQ24631354
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenibQ24655048
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampusQ24683755
Sirtuin functions and modulation: from chemistry to the clinicQ26745884
A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditionsQ26781560
The functions of animal microRNAsQ27860621
The widespread regulation of microRNA biogenesis, function and decayQ28131796
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapyQ28282855
Neuroprotective Sirtuin ratio reversed by ApoE4Q28300666
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activityQ40360129
Genomic structure and functional characterization of the human ADAM10 promoterQ40406214
Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cellsQ40430504
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.Q40457061
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.Q40520119
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated regionQ40601806
Intrahippocampal Administration of Ibotenic Acid Induced Cholinergic Dysfunction via NR2A/NR2B Expression: Implications of Resveratrol against Alzheimer Disease PathophysiologyQ40622685
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.Q40789097
G-quadruplexes: the beginning and end of UTRsQ41847081
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretaseQ42059040
Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptidesQ43636525
Effects of Zn(2+), Ca(2+), and Mg(2+) on the structure of Zn(7)metallothionein-3: evidence for an additional zinc binding siteQ43665222
Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptideQ43683499
Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: structure-activity studiesQ44265128
BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluidQ44408042
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's diseaseQ44444828
Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levelsQ44530237
Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's diseaseQ45009958
Disruption of the retinoid signalling pathway causes a deposition of amyloid beta in the adult rat brainQ45014651
Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.Q45963204
Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trialsQ46390270
ADAM and Eph: how Ephrin-signaling cells become detachedQ46765672
Diversity of microRNAs in human and chimpanzee brainQ47179611
Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.Q47311068
Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cellsQ47617536
microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease.Q47646473
ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's diseaseQ47728000
Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's diseaseQ47908768
Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's diseaseQ48070770
Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF).Q48103518
Levels of beta-secretase (BACE1) in cerebrospinal fluid as a predictor of risk in mild cognitive impairmentQ48147007
Metallothionein-I and -III expression in animal models of Alzheimer diseaseQ48402258
Changes in melatonin secretion with age and pubescenceQ48409455
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.Q48492125
Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.Q48552163
Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impairedQ48560961
Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's diseaseQ48570738
Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-wakingQ48770281
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob diseaseQ48795523
Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's diseaseQ48895286
Metallothionein III is reduced in Alzheimer's diseaseQ48955424
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X SyndromeQ50259561
Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer's Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study.Q50663391
Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5' Untranslated Region (UTR) of Its mRNA.Q50994587
Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer's Disease Platelets.Q51061879
Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease.Q51212850
The Roles of Endoplasmic Reticulum Stress in the Pathophysiological Development of Cartilage and Chondrocytes.Q51361479
Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17.Q52994249
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.Q53222639
Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin.Q53358084
Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients.Q53370360
SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus.Q53417845
Alterations in Nocturnal Serum Melatonin Levels In Humans With Growth and Aging*Q68291626
A note on the relevance of [6]-Gingerol for the prevention and/or treatment of Alzheimer's diseaseQ85472485
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based studyQ28366850
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brainQ28507690
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activityQ28511294
Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25-35 in rat cortical neuronsQ28580285
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ developmentQ28587012
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's diseaseQ29048183
Therapeutic potential of resveratrol: the in vivo evidenceQ29547413
The RXR heterodimers and orphan receptorsQ29547867
APP processing and synaptic functionQ29615873
PDZ domain proteins of synapsesQ29616399
Sex and gender differences in the treatment of Alzheimer's disease: A systematic review of randomized controlled trialsQ30240257
Protective effect of melatonin on beta-amyloid-induced apoptosis in rat astroglioma C6 cells and its mechanismQ33208711
The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target?Q33634629
PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cellsQ34005367
Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depressionQ34111025
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of miceQ34222321
Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.Q34272420
Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesisQ34299878
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.Q34414355
Pax genes and organogenesis.Q34439185
Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's diseaseQ34543231
SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylationQ34662305
Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.Q34737994
Inhibition of Alzheimer beta-fibrillogenesis by melatoninQ34746395
Evidence for defective retinoid transport and function in late onset Alzheimer's diseaseQ34809021
Cholesterol and pathological processes in Alzheimer's diseaseQ34976268
Statins and their role in vascular protectionQ35148303
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humansQ35202803
Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal originQ35558510
The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage SiteQ35583121
PAX Genes in Cancer; Friends or Foes?Q35714437
Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APPQ35845926
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD miceQ35996371
Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's diseaseQ36137410
Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragmentQ39382095
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.Q39422025
[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense systemQ39577488
Activation of α-secretase by curcumin-aminoacid conjugatesQ39586120
Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing.Q39661608
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesisQ39711618
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generationQ39726471
Regulation of secretases by all-trans-retinoic acidQ39846093
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretinQ39895248
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factorQ39921892
Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons.Q39938504
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated regionQ40041919
Statins reduce amyloid-beta production through inhibition of protein isoprenylationQ40103529
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.Q40269778
Shedding light on ADAM metalloproteinasesQ36159565
A PANorama of PAX genes in cancer and developmentQ36362388
Re-assessing the relationship between cholesterol, statins and Alzheimer's diseaseQ36546507
Retinoid receptors, transporters, and metabolizers as therapeutic targets in late onset Alzheimer diseaseQ36604044
Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysisQ37151717
Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α.Q37244012
All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's diseaseQ37630540
A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1.Q37820658
A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2.Q37824843
α-Secretase in Alzheimer's disease and beyond: mechanistic, regulation and function in the shedding of membrane proteinsQ37878498
Alpha-secretase cleavage of the amyloid precursor protein: proteolysis regulated by signaling pathways and protein traffickingQ37878501
Melatonin as a natural ally against oxidative stress: a physicochemical examination.Q37900675
Alzheimer's disease: pathological mechanisms and the beneficial role of melatoninQ37959556
MicroRNA networks surrounding APP and amyloid-β metabolism--implications for Alzheimer's diseaseQ37961383
MicroRNAs in Alzheimer's diseaseQ37979612
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK.Q38045452
Alzheimer's disease, cholesterol, and statins: the junctions of important metabolic pathwaysQ38071004
Tetraspanin proteins promote multiple cancer stagesQ38186043
[6]-gingerol as a cancer chemopreventive agent: a review of its activity on different steps of the metastatic processQ38189458
Tetraspanins at a glance.Q38240344
The transcription factor X-box binding protein-1 in neurodegenerative diseasesQ38248723
Strategy to reduce free radical species in Alzheimer's disease: an update of selected antioxidants.Q38253060
Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changesQ38310017
The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease?Q38359533
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brainQ38622031
Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levelsQ38802753
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's DiseaseQ38977248
Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β.Q38987753
Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.Q38991860
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.Q39069488
High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammationQ39138022
Mechanisms of Melatonin in Alleviating Alzheimer's DiseaseQ39178920
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based MechanismsQ39214249
Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.Q39376860
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectAlzheimer's diseaseQ11081
P577publication date2018-01-29
P1433published inPharmaceuticalsQ15750667
P1476titleAlpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment.
P478volume11

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cites work (P2860)
Q64084359Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice
Q89879825Enhancing α-secretase Processing for Alzheimer's Disease-A View on SFRP1
Q89965577Modulation of Immune Responses by Platelet-Derived ADAM10
Q89187503Novel therapies for combating chronic neuropathological sequelae of TBI
Q60046944Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease
Q89578231Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor

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