| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Costas Koumenis | Q56559519 |
| P2093 | author name string | J Alan Diehl | |
| Serge Y Fuchs | |||
| P2860 | cites work | Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors | Q22008465 |
| XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 | ||
| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
| SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor | Q24297139 | ||
| A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Q24309442 | ||
| Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes | Q24313314 | ||
| Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control | Q24522941 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif | Q24649769 | ||
| Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex | Q24670129 | ||
| CDK inhibitors: positive and negative regulators of G1-phase progression | Q27860983 | ||
| EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome | Q28142981 | ||
| Translational control is required for the unfolded protein response and in vivo glucose homeostasis | Q28204066 | ||
| IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
| Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway | Q28237113 | ||
| Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase | Q28296183 | ||
| The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas | Q28505821 | ||
| Regulated translation initiation controls stress-induced gene expression in mammalian cells | Q28506388 | ||
| PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation | Q28507769 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum | Q28509611 | ||
| Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis | Q28588618 | ||
| PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway | Q28592902 | ||
| Autophagy: process and function | Q29547296 | ||
| Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response | Q29547299 | ||
| Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls | Q29547730 | ||
| PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice | Q30945763 | ||
| Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response | Q33264844 | ||
| The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. | Q33559643 | ||
| Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor | Q33593849 | ||
| Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein | Q33717136 | ||
| PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage | Q33977034 | ||
| Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro | Q34428880 | ||
| Viruses, endoplasmic reticulum stress, and interferon responses | Q34482331 | ||
| Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2 | Q34528431 | ||
| The unfolded protein response in nutrient sensing and differentiation | Q34664763 | ||
| Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and STAT-3. | Q34989433 | ||
| Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression | Q35552863 | ||
| Endoplasmic reticulum stress triggers autophagy | Q35690087 | ||
| The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis | Q35830099 | ||
| Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response | Q36322641 | ||
| XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. | Q36322684 | ||
| Divergent roles of IRE1alpha and PERK in the unfolded protein response | Q36393483 | ||
| Ligand-independent pathway that controls stability of interferon alpha receptor | Q36477315 | ||
| Negative regulation of type I interferon signaling: facts and mechanisms. | Q36567853 | ||
| Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C. | Q36588196 | ||
| The unfolded protein response and autophagy: herpesviruses rule! | Q37266997 | ||
| Innate immunity and hepatitis C virus: eluding the host cell defense | Q37501771 | ||
| Regulation of autophagy by ATF4 in response to severe hypoxia. | Q38343634 | ||
| ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth | Q39470144 | ||
| Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. | Q39791119 | ||
| HCV structural proteins interfere with interferon-alpha Jak/STAT signalling pathway | Q40098380 | ||
| IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. | Q40105547 | ||
| Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest | Q40246328 | ||
| XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. | Q40519913 | ||
| Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor | Q40520820 | ||
| Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation | Q40793113 | ||
| Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase | Q40858827 | ||
| West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion | Q41971863 | ||
| Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage | Q42026405 | ||
| Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress | Q42163338 | ||
| TYK2 activity promotes ligand-induced IFNAR1 proteolysis | Q42407864 | ||
| Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor | Q42551996 | ||
| Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor. | Q42634140 | ||
| Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis. | Q42832143 | ||
| Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance | Q42990051 | ||
| "ER stress(ed out)!": Paneth cells and ischemia-reperfusion injury of the small intestine | Q43232082 | ||
| In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C. | Q44332232 | ||
| No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection | Q45369635 | ||
| Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein | Q46184732 | ||
| Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum | Q50336389 | ||
| PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. | Q52000258 | ||
| Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. | Q53294250 | ||
| Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions | Q73639378 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| P304 | page(s) | 38-41, 41.e1-2 | |
| P577 | publication date | 2011-05-24 | |
| P1433 | published in | Gastroenterology | Q4039279 |
| P1476 | title | The cell biology of the unfolded protein response | |
| P478 | volume | 141 |
| Q46244712 | A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. |
| Q36040206 | ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. |
| Q39264002 | Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses |
| Q28481001 | Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response |
| Q64111428 | Cellular Proteostasis During Influenza A Virus Infection-Friend or Foe? |
| Q27692108 | Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation. |
| Q26781215 | Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies |
| Q36828440 | Copa Syndrome: a Novel Autosomal Dominant Immune Dysregulatory Disease |
| Q90168279 | ER stress and UPR activation in glioblastoma: identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation |
| Q34001064 | ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway |
| Q38557011 | Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease |
| Q28487624 | Endoplasmic reticulum stress-induced resistance to doxorubicin is reversed by paeonol treatment in human hepatocellular carcinoma cells |
| Q37445690 | Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation |
| Q40443053 | Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice. |
| Q48254706 | Gold nanoparticle interactions with endothelial cells cultured under physiological conditions. |
| Q92309590 | Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress |
| Q38097519 | Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy |
| Q55022007 | Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach. |
| Q38702710 | Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation |
| Q41640017 | Loss of ion transporters and increased unfolded protein response in Fuchs' dystrophy |
| Q58572489 | Low expression of miR-199 in hepatocellular carcinoma contributes to tumor cell hyper-proliferation by negatively suppressing XBP1 |
| Q38552126 | Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis |
| Q38089680 | Novel interactions of GRP78: UPR and estrogen responses in the brain. |
| Q38421096 | OSAS-related inflammatory mechanisms of liver injury in nonalcoholic fatty liver disease. |
| Q39392716 | OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing |
| Q38139255 | Oncolytic virotherapy and immunogenic cancer cell death: sharpening the sword for improved cancer treatment strategies |
| Q35716234 | PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis |
| Q36224716 | PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. |
| Q36435206 | PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis |
| Q45486819 | Prostaglandin E1 protects hepatocytes against endoplasmic reticulum stress-induced apoptosis via protein kinase A-dependent induction of glucose-regulated protein 78 expression |
| Q33682452 | Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase |
| Q26853645 | Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease |
| Q34438487 | SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling |
| Q37653336 | SERPINB3 and B4: From biochemistry to biology |
| Q89531647 | Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy |
| Q38198021 | The ER quality control and ER associated degradation machineries are vital for viral pathogenesis |
| Q52583601 | The Role of IRE1 Signaling in Central Nervous System Diseases. |
| Q37285838 | The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies |
| Q39139037 | The role of the unfolded protein response in dengue virus pathogenesis. |
| Q36288351 | The unfolded protein response is activated in connexin 50 mutant mouse lenses. |
| Q36394344 | Type I interferons mediate pancreatic toxicities of PERK inhibition |
| Q92069621 | Unfolded Protein Response and Cancer |
| Q35025407 | Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response |
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