Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism

scientific article published on 19 August 2016

Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1043287353
P356DOI10.1038/SREP31381
P932PMC publication ID4990971
P698PubMed publication ID27539723

P50authorJiajun ZhaoQ59161479
P2093author name stringWenbin Chen
Ling Gao
Chao Xu
Congcong Li
Yujie Li
Xiaojing Liu
Lingyan Zhou
Tao Bo
Laicheng Wang
Kunpeng Wu
Shuyan Ding
P2860cites workLaboratory diagnosis of Niemann-Pick disease type C: the filipin staining test.Q50961543
The effects of subclinical hypothyroidism on serum lipid level and TLR4 expression of monocyte in peripheral blood of rats.Q51154138
Non-alcoholic fatty liver disease across the spectrum of hypothyroidism.Q51352743
Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis.Q51502500
Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.Q54338450
Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.Q54447692
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam StudyQ73462518
UCP1 is essential for adaptive adrenergic nonshivering thermogenesisQ83092333
Subclinical thyroid diseaseQ83315660
Thyroid disease--more research neededQ83736955
A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element bindingQ84583822
Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosisQ86028685
Berberine activates thermogenesis in white and brown adipose tissueQ86052055
Membrane lipids: where they are and how they behaveQ24653084
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver diseaseQ26853645
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein responseQ29547299
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task ForceQ30827881
Regulated increase in folding capacity prevents unfolded protein stress in the ER.Q30977675
The Colorado thyroid disease prevalence studyQ33891706
Alteration of lipid profile in subclinical hypothyroidism: a meta-analysisQ34090126
Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).Q34113424
Alteration of lipid parameters in patients with subclinical hypothyroidismQ34197012
Clinical practice. Subclinical hypothyroidismQ34320221
Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 yearsQ35746991
A high normal TSH level is associated with an atherogenic lipid profile in euthyroid non-smokers with newly diagnosed asymptomatic coronary heart diseaseQ35903038
ER stress: can the liver cope?Q36517489
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Methimazole-induced cholestatic hepatitis: two cases report and literature reviewQ36782685
Prevalence, clinical and biochemical profile of subclinical hypothyroidism in normal population in MumbaiQ37015999
Dyslipidaemic changes in women with subclinical hypothyroidismQ37349824
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesisQ37760005
Status of thyroid function in Indian adults: two decades after universal salt iodizationQ38048790
Assessment of brown adipose tissue functionQ38113991
The development and progression of atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling.Q38132458
Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cellsQ39148101
TSH regulates a gene expression encoding ERp29, an endoplasmic reticulum stress protein, in the thyrocytes of FRTL-5 cells.Q40873768
Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum.Q41618670
Regulation of apoptosis by the unfolded protein response.Q42159220
Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones-neurotransmitters and adenosinergic system interactionsQ42990120
Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: a prospective case-control study.Q44045476
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Impaired learning and memory performance in a subclinical hypothyroidism rat model induced by hemi-thyroid electrocauterisationQ48665473
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)31381
P577publication date2016-08-19
P1433published inScientific ReportsQ2261792
P1476titleEndoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism
P478volume6

Reverse relations

cites work (P2860)
Q64980705Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism.
Q52326681Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity.
Q69394578Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?
Q36395221Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production
Q89495580Integrated microRNA and proteome analysis reveal a regulatory module in hepatic lipid metabolism disorders in mice with subclinical hypothyroidism
Q50089788Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms
Q50204233TSHB mRNA is linked to cholesterol metabolism in adipose tissue.

Search more.