Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats

Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2019/9417498
P932PMC publication ID6446099
P698PubMed publication ID31015892

P2093author name stringHeraldo Possolo de Souza
Antonio Marcus de Andrade Paes
Lucas Martins França
Vinicyus Teles Chagas
Francisco Rafael Martins Laurindo
Thais Martins de Lima
Victor Debbas
Caio Fernando Ferreira Coêlho
Ivana Letícia Santos Souza
Larissa Nara Costa Freitas
P2860cites workPomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice.Q50456080
Correlation between 'Lee index' and carcass fat content in weanling and adult female rats with hypothalamic lesions.Q51188133
Syzygium cumini ameliorates insulin resistance and β-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-α in type 2 diabetic rats.Q51354183
Fat storage is partially dependent on vagal activity and insulin secretion of hypothalamic obese rat.Q51463387
Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.Q54447692
XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism.Q55031705
Protective Effects of a Polyphenol-Rich Extract from (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic RatsQ57922846
Anti-diabetic Effect of Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3β and Inhibition of IRE1α-XBP1 PathwaysQ58122031
Kaempferol protects ischemia/reperfusion-induced cardiac damage through the regulation of endoplasmic reticulum stressQ81495312
Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterationsQ84585494
M10, a novel derivative of Myricetin, prevents ulcerative colitis and colorectal tumor through attenuating robust endoplasmic reticulum stressQ88661452
The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic womenQ95492341
Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases.Q38658008
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.Q38680300
Selective Inhibition of PTP1B by Vitalboside A from Syzygium cumini Enhances Insulin Sensitivity and Attenuates Lipid Accumulation Via Partial Agonism to PPARγ: In Vitro and In Silico InvestigationQ38785251
Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitisQ38890692
Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.Q39008193
Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosisQ39701311
Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in ratsQ40021459
Constituents from Terminalia species increase PPARα and PPARγ levels and stimulate glucose uptake without enhancing adipocyte differentiationQ42816593
Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice.Q43814761
Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic ratsQ44476897
Chromatographic analysis of lipid fractions in healthy dogs and dogs with obesity or hyperadrenocorticism.Q46088144
The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjectsQ46207788
Effect of the extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic miceQ46627731
Effects of crude hydroalcoholic extract of Syzygium cumini (L.) Skeels leaves and continuous aerobic training in rats with diabetes induced by a high-fat diet and low doses of streptozotocinQ47262489
Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factorQ49015299
Future challenges for microsomal transport protein inhibitorsQ50327165
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver diseaseQ26853645
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged MiceQ28292783
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
A systematic review of medicinal plants used for weight loss in Brazil: Is there potential for obesity treatment?Q30380911
Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic programQ30426645
Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional usesQ31114936
Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose dietQ34347888
Myricetin Increases Hepatic Peroxisome Proliferator-Activated Receptor α Protein Expression and Decreases Plasma Lipids and Adiposity in RatsQ35846423
Syzygium cumini (L.) skeels: a prominent source of bioactive molecules against cardiometabolic diseasesQ36241956
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implicationsQ36617551
Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats.Q36669997
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environmentsQ37124391
Syzygium cumini (L.) SKEELS (Myrtaceae) against diabetes--125 years of researchQ37124847
A target based therapeutic approach towards diabetes mellitus using medicinal plantsQ37320176
New lipid modulating drugs: the role of microsomal transport protein inhibitorsQ37854785
Endoplasmic reticulum stress, obesity and diabetesQ37926034
Natural products: a safest approach for obesity.Q38028421
Postprandial hypertriglyceridemia as a coronary risk factorQ38186473
Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic diseaseQ38250379
XBP1s Is an Anti-lipogenic ProteinQ38291938
A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndromeQ38330522
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthypertriglyceridemiaQ1467339
leaf extractQ129177468
P304page(s)9417498
P577publication date2019-01-01
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleLeaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats
P478volume2019

Reverse relations

cites work (P2860)
Q91871195Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
Q96135891Natural products as safeguards against monosodium glutamate-induced toxicity

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