Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease

scientific article published on 27 February 2019

Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DMM.037242
P932PMC publication ID6398494
P698PubMed publication ID30733237

P50authorHippokratis KiarisQ39944380
P2093author name stringIoulia Chatzistamou
Amanda Havighorst
Elena Farmaki
Youwen Zhang
Vimala Kaza
P2860cites workFuel selection in Wistar rats exposed to cold: shivering thermogenesis diverts fatty acids from re-esterification to oxidation.Q45923770
Dyslipidemia without obesity in indigenous Argentinean children living at high altitudeQ47671807
Lipid profile, waist circumference, and body mass index in a high altitude populationQ57106002
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathwaysQ24300926
Regulatory changes contribute to the adaptive enhancement of thermogenic capacity in high-altitude deer miceQ24614798
Endoplasmic reticulum stress and type 2 diabetesQ26864238
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Primer3--new capabilities and interfacesQ29614816
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in miceQ34322168
Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.Q34426580
Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged miceQ34529312
Quantitative dissection of the simple repression input-output functionQ35123050
Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regressionQ35484712
Peromyscus mice as a model for studying natural variationQ35750672
Genetic variation in laboratory miceQ36299344
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.Q36497621
Aging promotes the development of diet-induced murine steatohepatitis but not steatosisQ36592331
Endoplasmic reticulum stress sensing in the unfolded protein responseQ36626672
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine modelQ37257204
GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.Q37714508
Targeting the unfolded protein response in disease.Q38132652
Peromyscus (deer mice) as developmental modelsQ38217598
XBP1s Is an Anti-lipogenic ProteinQ38291938
ER stress and the unfolded protein response in neurodegenerationQ38653861
Genetic and hormonal control of hepatic steatosis in female and male miceQ38798845
The role of ER stress in lipid metabolism and lipotoxicityQ38825911
Peromyscus as a model of human diseaseQ38885197
Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell deathQ39080237
The UPRER: Sensor and Coordinator of Organismal HomeostasisQ39378731
Competitive inhibition of a set of endoplasmic reticulum protein genes (GRP78, GRP94, and ERp72) retards cell growth and lowers viability after ionophore treatmentQ41676067
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in miceQ41825121
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stressQ42451739
Elevation of serum cholesterol at high altitude and its relationship to hematocritQ44274767
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmetabolic diseaseQ2351083
predictionQ748250
P304page(s)dmm037242
P577publication date2019-02-27
P1433published inDisease Models & MechanismsQ1524006
P1476titleDifferential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease
P478volume12

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Q89951202Identification of frailty-associated genes by coordination analysis of gene expressioncites workP2860

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