GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.

scientific article published on 21 October 2013

GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2013.437
P932PMC publication ID3994182
P698PubMed publication ID24141775

P2093author name stringG Zhu
W-T Chen
B Stiles
A S Lee
G Kanel
K Pfaffenbach
P2860cites workEssential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosisQ24323246
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitisQ24645373
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
The biology and clinical relevance of the PTEN tumor suppressor pathwayQ28272157
ER chaperones in mammalian development and human diseasesQ28300625
Early development of PAT-SM6 for the treatment of melanomaQ44736835
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein responseQ46116386
The ER function BiP is a master regulator of ER functionQ81006325
ATF4 regulates lipid metabolism and thermogenesisQ82468721
Molecular mechanisms of liver injury and hepatocarcinogenesis: focusing on the role of stress-activated MAPKQ28384866
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiPQ28476029
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinaseQ28508079
Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic valuesQ33231146
Grp78 promotes the invasion of hepatocellular carcinomaQ33524918
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistanceQ33556664
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow nicheQ33925176
Liver stem cells and their implication in hepatocellular and cholangiocarcinomaQ33997118
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.Q34118737
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.Q34314109
Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitisQ34358474
The critical role of GRP78 in physiologic and pathologic stress.Q34594217
Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78.Q34606433
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.Q34630557
Role of autophagy in liver physiology and pathophysiologyQ34878438
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic developmentQ35070987
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injuryQ35677684
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signalingQ35692042
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targetingQ35964550
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]Q36604703
GRP78 plays an essential role in adipogenesis and postnatal growth in miceQ36615162
GRP78 induction in cancer: therapeutic and prognostic implications.Q36794164
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epitheliumQ37039595
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapiesQ37285838
GRP78: a multifunctional receptor on the cell surfaceQ37426684
The role of signaling pathways in the development and treatment of hepatocellular carcinomaQ37773788
Liver stem/progenitor cells: their characteristics and regulatory mechanismsQ37827017
Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer.Q38095390
Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injuryQ38601609
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Q39656536
Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer.Q40112917
Ductular reaction in the liverQ40370388
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in miceQ41825121
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.Q42067728
Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytesQ42496198
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectsteatosisQ1365091
P304page(s)4997-5005
P577publication date2013-10-21
P1433published inOncogeneQ1568657
P1476titleGRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
P478volume33

Reverse relations

cites work (P2860)
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Q49846308GRP78 Promotes Hepatocellular Carcinoma proliferation by increasing FAT10 expression through the NF-κB pathway
Q28254667GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease
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