Calcium pumps in health and disease

scientific article published on October 2009

Calcium pumps in health and disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1152/PHYSREV.00032.2008
P698PubMed publication ID19789383
P5875ResearchGate publication ID26856214

P50authorErnesto CarafoliQ39956463
P2093author name stringMarisa Brini
P2860cites workDREAM is a Ca2+-regulated transcriptional repressorQ22009034
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey diseaseQ22010996
A single amino acid residue can determine the sensitivity of SERCAs to artemisininsQ22061863
Artemisinins target the SERCA of Plasmodium falciparumQ22061877
The mutation of Pro789 to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) and is associated with Brody diseaseQ22254688
Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteinsQ24290994
SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosisQ24291323
The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase IQ24291771
Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ exchanger regulatory factor 2 in apical plasma membranesQ24292155
A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafnessQ24293479
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4bQ24294192
Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targetingQ24297073
Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cellsQ24299890
Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.Q44909452
Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 bindingQ45238302
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brainQ45242024
Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicityQ45244063
Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosisQ45741819
Identification of a missense mutation in the bovine ATP2A1 gene in congenital pseudomyotonia of Chianina cattle: an animal model of human Brody disease.Q46023528
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ionsQ46438644
Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytesQ46485655
Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation.Q46608561
The plasma membrane Ca2+-ATPase isoform 4 is localized in lipid rafts of cerebellum synaptic plasma membranesQ46774418
Identification of mutations in the ATP2A2 gene in patients with Darier's disease from Hungary.Q47373686
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traitsQ47936547
Identification of a new SERCA2 splice variant regulated during monocytic differentiationQ48011065
Distribution of plasma membrane Ca2+ pump (PMCA) isoforms in the gerbil brain: effect of ischemia-reperfusion injuryQ48129937
The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase familyQ48292292
Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequenceQ48376136
Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycleQ48588931
The calcium-signalling saga: tap water and protein crystalsQ48697778
Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampusQ48720337
Acute barrier perturbation abolishes the Ca2+ and K+ gradients in murine epidermis: quantitative measurement using PIXE.Q52533031
Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.Q52540824
Alterations in the ATP2A2 gene in correlation with colon and lung cancer.Q53339844
GRP94 (endoplasmin) co-purifies with and is phosphorylated by Golgi apparatus casein kinase.Q53809608
Removal of Calcium and Relaxation in Actomyosin SystemsQ58996872
Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulumQ59054428
Evolution of substrate specificities in the P-type ATPase superfamily.Q34451276
Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.Q34548372
Highly effective SNP-based association mapping and management of recessive defects in livestockQ34762263
Curcumin and cancer: an "old-age" disease with an "age-old" solutionQ34776812
Phase II trial of curcumin in patients with advanced pancreatic cancerQ34796370
Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipetteQ35014276
Sticky business: orchestrating cellular signals at adherens junctionsQ35071400
When calcium goes wrong: genetic alterations of a ubiquitous signaling routeQ35140775
Phospholamban: a crucial regulator of cardiac contractilityQ35167969
Cadherins as Modulators of Cellular PhenotypeQ35564806
Localization of plasma membrane and secretory calcium pumps in the mammary gland.Q35602410
Working out the strength and flexibility of desmosomesQ35741011
The role of the calcium-sensing receptor in epidermal differentiationQ35807146
Calcium-mediated cellular signals: a story of failuresQ35827612
Phenotypes of SERCA and PMCA knockout miceQ35874299
The SERCA pump as a therapeutic target: making a "smart bomb" for prostate cancerQ36015748
Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic ReticulumQ36072362
Hailey-Hailey disease as an orthodisease of PMR1 deficiency in Saccharomyces cerevisiaeQ36089572
Calcium pump of the plasma membrane is localized in caveolaeQ36233042
The calmodulin-binding site of the plasma membrane Ca2+ pump interacts with the transduction domain of the enzymeQ36277445
Ca2+-dependent redox modulation of SERCA 2b by ERp57.Q36321740
Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2bQ36328290
Microdomains of intracellular Ca2+: molecular determinants and functional consequences.Q36350079
Involvement of the adherens junction-actin filament system in acantholytic dyskeratosis of Hailey-Hailey disease. A histological, ultrastructural, and histochemical study of lesional and non-lesional skinQ36818115
Calcium and cancer: targeting Ca2+ transportQ36856463
Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stressQ36857266
Characterization of the Golgi complex cleared of proteins in transit and examination of calcium uptake activitiesQ36928765
Polarized calcium signaling in exocrine gland cellsQ36938402
The regulatory function of plasma-membrane Ca(2+)-ATPase (PMCA) in the heartQ36979463
Physiological implications of the interaction between the plasma membrane calcium pump and nNOS.Q37070313
A defective SERCA1 protein is responsible for congenital pseudomyotonia in Chianina cattleQ37071895
Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulumQ37153977
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic miceQ37350650
2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores.Q43476586
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heartQ43778748
Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP.Q43815503
Functional role of "N" (nucleotide) and "P" (phosphorylation) domain interactions in the sarcoplasmic reticulum (SERCA) ATPaseQ43883473
Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.Q43979706
Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice.Q44295699
Mechanism of action of the novel plasma membrane Ca(2+)-pump inhibitor caloxinQ44346122
A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cellsQ44418943
Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivityQ44506957
Regulation of vascular tone in animals overexpressing the sarcolemmal calcium pumpQ44538203
Altered force-frequency response in non-failing hearts with decreased SERCA pump-levelQ44590302
Impaired trafficking of the desmoplakins in cultured Darier's disease keratinocytesQ44693127
The mitochondrial calcium uniporter is a highly selective ion channel.Q44737530
CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activityQ44888575
Modification of human hearing loss by plasma-membrane calcium pump PMCA2Q24300034
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ storesQ24300260
Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)Q24300332
Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c)Q24300590
Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variantsQ24302410
The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interferenceQ24304991
Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heartQ24305007
Similar Ca(2+)-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca(2+)-ATPase SPCA1Q24305341
Mutations in the gene-encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody diseaseQ24311805
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heartQ24311811
Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPaseQ24313260
Ca2+ homeostasis in Brody's disease. A study in skeletal muscle and cultured muscle cells and the effects of dantrolene an verapamilQ24315120
Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody diseaseQ24336206
Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analysesQ24337167
Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholambanQ24528081
A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell linesQ24534220
Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase.Q24541329
Phospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPasesQ24555223
Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptorQ24562637
Core signaling pathways in human pancreatic cancers revealed by global genomic analysesQ24606006
Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumenQ24671902
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesisQ24675477
The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident proteinQ24682684
NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pumpQ27619672
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolutionQ27625023
Structural changes in the calcium pump accompanying the dissociation of calciumQ27639472
The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pumpQ27643680
Manganese selectivity of pmr1, the yeast secretory pathway ion pump, is defined by residue gln783 in transmembrane segment 6. Residue Asp778 is essential for cation transportQ27930906
The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distributionQ27935902
An N-terminal EF hand-like motif modulates ion transport by Pmr1, the yeast Golgi Ca(2+)/Mn(2+)-ATPaseQ27939174
Darier-White disease: A review of the clinical features in 163 patientsQ28111481
Structure and regulation of voltage-gated Ca2+ channelsQ28141138
Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pumpQ28141980
Human calumenin localizes to the secretory pathway and is secreted to the mediumQ28142715
Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca(2+)-ATPase forms a functional interaction site with phospholamban. Evidence for physical interactions at other sitesQ28146231
Generation, control, and processing of cellular calcium signalsQ28190306
Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASKQ28201604
Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cellsQ28202752
Are desmosomes more than tethers for intermediate filaments?Q28205062
Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 familyQ28214899
Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiationQ28216340
Protein degradation by the ubiquitin-proteasome pathway in normal and disease statesQ28243121
Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWVQ28247378
Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 geneQ28251173
Hailey-Hailey disease: identification of novel mutations in ATP2C1 and effect of missense mutation A528P on protein expression levelsQ28266529
Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2Q28276753
Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler miceQ28279035
Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequencesQ28285061
Cardiac adenoviral S100A1 gene delivery rescues failing myocardiumQ28296403
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing lossQ28473896
Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulationQ28509802
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertilityQ28512314
The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pumpQ28575155
Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cellsQ28578197
Characterization of Cos-7 cells overexpressing the rat secretory pathway Ca2+-ATPaseQ28580806
A point mutation in a plasma membrane Ca(2+)-ATPase gene causes deafness in Wriggle Mouse SagamiQ28587314
Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milkQ28589621
ATP-dependent Ca++-extrusion from human red cellsQ28609353
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signalsQ28631532
Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pumpQ28941770
The versatility and universality of calcium signallingQ29547402
TRP channelsQ29616673
Store-operated calcium channelsQ29617459
Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cellsQ30420604
Differential modulation of SERCA2 isoforms by calreticulinQ30442089
Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPaseQ30467346
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta productionQ30482542
Low endolymph calcium concentrations in deafwaddler2J mice suggest that PMCA2 contributes to endolymph calcium maintenanceQ30492656
Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).Q31061689
Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pumpQ31171355
The Golgi PMR1 P-type ATPase of Caenorhabditis elegans. Identification of the gene and demonstration of calcium and manganese transportQ31780083
Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pumpQ33222420
Caloxins: a novel class of selective plasma membrane Ca2+ pump inhibitors obtained using biotechnologyQ33301157
Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestineQ33352566
Calcium controls the transcription of its own transporters and channels in developing neurons.Q33797935
Discovery of phospholamban. A personal historyQ33798484
Abnormal intracellular ca(2+)homeostasis and diseaseQ34003108
H+ countertransport and electrogenicity of the sarcoplasmic reticulum Ca2+ pump in reconstituted proteoliposomesQ34092369
Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's diseaseQ34172235
Dilated cardiomyopathy and heart failure caused by a mutation in phospholambanQ34180320
Muscle contracture induced by exercise. A syndrome attributable to decreased relaxing factorQ34204742
The Ca2+/Mn2+ pumps in the Golgi apparatus.Q34375029
Ligand-gated calcium channels inside and out.Q34395653
Cardiomyopathies: from genetics to the prospect of treatmentQ34444836
Caveolae in smooth muscles: nanocontactsQ37600241
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPaseQ37726811
Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPaseQ38344356
The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease proteinQ38353817
Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery.Q39737608
Effects of lanthanum on calcium-dependent phenomena in human red cellsQ39866065
Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutaseQ40015787
Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPaseQ40096871
Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesteraseQ40096880
TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes.Q40123571
Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation.Q40166953
The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complexQ40273656
The role of calcium in cell deathQ40316829
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.Q40342843
Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.Q40348052
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines.Q40363562
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.Q40410135
Antisense-mediated Inhibition of the plasma membrane calcium-ATPase suppresses proliferation of MCF-7 cellsQ40418313
Ca2+ homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cellsQ40605826
Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analysesQ40634430
Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cellsQ40748649
Ca2+ currents in compensated hypertrophy and heart failure.Q40856650
Single amino acid mutations in transmembrane domain 5 confer to the plasma membrane Ca2+ pump properties typical of the Ca2+ pump of endo(sarco)plasmic reticulumQ40868051
Modulation of endoplasmic reticulum calcium pump by Bcl-2.Q41000205
Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cellsQ41061988
Phospholamban inhibitory function is activated by depolymerizationQ41105112
The SERCA3-type of organellar Ca2+ pumpsQ41125833
Expression and functional characterization of isoforms 4 of the plasma membrane calcium pumpQ41191005
The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholambanQ41191898
Dependence of epithelial intercellular junction biogenesis on thapsigargin-sensitive intracellular calcium storesQ41192622
Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi networkQ41654828
Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy.Q41823396
The functional importance of the extreme C-terminal tail in the gene 2 organellar Ca(2+)-transport ATPase (SERCA2a/b).Q41958734
Close proximity between residue 30 of phospholamban and cysteine 318 of the cardiac Ca2+ pump revealed by intermolecular thiol cross-linking.Q42051533
Functional Co-expression of the canine cardiac Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulationQ42062144
Casein kinase activity in rat mammary gland Golgi vesicles. Demonstration of latency and requirement for a transmembrane ATP carrierQ42178286
Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexiaQ42276050
Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handlingQ42437972
Effects of 4-OH-2,3-trans-nonenal on human erythrocyte plasma membrane Ca2+ pump and passive Ca2+ permeabilityQ42440499
Plasma Membrane Ca2+ Pump Isoforms 2a and 2b Are Unusually Responsive to Calmodulin and Ca2+Q42441018
Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressureQ42446511
Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatasesQ42479113
ATP2C1 is specifically localized in the basal layer of normal epidermis and its depletion triggers keratinocyte differentiationQ42493449
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosageQ42512972
Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytesQ42522846
SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells.Q42527308
Modulations in epidermal calcium regulate the expression of differentiation-specific markersQ42528076
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotesQ42624776
The plasma membrane calcium ATPase (PMCA) of neurones is electroneutral and exchanges 2 H+ for each Ca2+ or Ba2+ ion extrudedQ42738871
Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).Q42808518
The erythrocyte calcium pump is inhibited by non-enzymic glycation: studies in situ and with the purified enzymeQ42810803
Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neuronsQ43113816
P433issue4
P921main subjectcalciumQ706
P304page(s)1341-1378
P577publication date2009-10-01
P1433published inPhysiological ReviewsQ1091827
P1476titleCalcium pumps in health and disease
P478volume89

Reverse relations

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Q40393865Computational reconstitution of spine calcium transients from individual proteins
Q36895617Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling
Q37482882Crystal structures of the TRIC trimeric intracellular cation channel orthologues
Q46543447Curcumin promotes exosomes/microvesicles secretion that attenuates lysosomal cholesterol traffic impairment
Q34314347Cyst formation following disruption of intracellular calcium signaling
Q41959197Cytosolic calcium measurements in renal epithelial cells by flow cytometry
Q36385413Decreases in plasma membrane Ca²⁺-ATPase in brain synaptic membrane rafts from aged rats
Q36635803Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.
Q42419382Deletions and mutations in the acidic lipid-binding region of the plasma membrane Ca2+ pump: a study on different splicing variants of isoform 2.
Q90399859Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan
Q52641256Dickkopf‑3 upregulation mediates the cardioprotective effects of curcumin on chronic heart failure.
Q52992362Differential calcium handling by the cis and trans regions of the Golgi apparatus.
Q90465634Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types
Q44993135Differential mechanism of the effects of ester-type local anesthetics on sarcoplasmic reticulum Ca-ATPase
Q36294647Distinctive features of catalytic and transport mechanisms in mammalian sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) and Cu+ (ATP7A/B) ATPases
Q52562558Drug Interactions With the Ca2+-ATPase From Sarco(Endo)Plasmic Reticulum (SERCA).
Q40738541Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle
Q34719781Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations
Q90052987ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions
Q58091174Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells
Q47764394Effect of tapering after a period of high-volume sprint interval training on running performance and muscular adaptations in moderately trained runners
Q36579514Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis
Q39015164Effects of passage number on proliferation and store-operated calcium entry in A7r5 vascular smooth muscle cells.
Q58801192Efficacy of magnesium chloride in the treatment of Hailey-Hailey disease: from serendipity to evidence of its effect on intracellular Ca2+homeostasis
Q51737093Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes.
Q38073952Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
Q37889807Endoplasmic reticulum calcium pumps and cancer
Q33649613Endoplasmic reticulum calcium pumps and cancer cell differentiation
Q37214854Endoplasmic reticulum stress and calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces cerevisiae
Q37858336Endoplasmic-reticulum calcium depletion and disease
Q42414567Energy variational analysis of ions in water and channels: Field theory for primitive models of complex ionic fluids
Q38748569Essential role of Na+/Ca2+ exchanger 1 in smoking-induced growth and migration of esophageal squamous cell carcinoma
Q51801685Evidence for a role of plasma membrane calcium pumps in neurodegenerative disease: Recent developments.
Q39441714Evolutionary Cell Biology of Proteins from Protists to Humans and Plants.
Q42459844Excitation-contraction coupling properties in women with work-related myalgia: a preliminary study.
Q35000743Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility
Q51735696Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.
Q45241242Expression of sarcoplasmic-endoplasmic reticulum Ca-ATPase isoforms in masticatory muscles
Q57182332From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation
Q98906757Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells
Q90473320Gastroparesis in the 2020s: New Treatments, New Paradigms
Q55406267Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy.
Q28943391Genome-wide association study indicates two novel resistance loci for severe malaria
Q28554351Global Analysis of Type Three Secretion System and Quorum Sensing Inhibition of Pseudomonas savastanoi by Polyphenols Extracts from Vegetable Residues
Q30659537Global calcium transducer P-type Ca²⁺-ATPases open new avenues for agriculture by regulating stress signalling
Q42973584Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: the role of intracellular [Ca2+].
Q34333651Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231
Q36331808HER2 signaling regulates HER2 localization and membrane retention
Q37851497Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease
Q40547097Heterozygous inactivation of plasma membrane Ca(2+)-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability
Q88876404High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA
Q39757664Highly cooperative dependence of sarco/endoplasmic reticulum calcium ATPase SERCA2a pump activity on cytosolic calcium in living cells
Q38838705Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines
Q38110512How animals move: comparative lessons on animal locomotion
Q37050830Human Milk Cells Contain Numerous miRNAs that May Change with Milk Removal and Regulate Multiple Physiological Processes.
Q36285059Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle
Q33848906Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
Q38109649Impairment of calcium ATPases by high glucose and potential pharmacological protection.
Q47943096In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes
Q38756996Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells
Q51012051Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1).
Q39378745Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling
Q26747203Intracellular Calcium Dysregulation: Implications for Alzheimer's Disease
Q37942052Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?
Q44898847Ionic leakage underlies a gain-of-function effect of dominant disease mutations affecting diverse P-type ATPases.
Q35102159Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study
Q47880116Iron overload impact on P-ATPases
Q36564069Isotope labeling for solution and solid-state NMR spectroscopy of membrane proteins
Q46907394Knockdown of STIM1 inhibits 6-hydroxydopamine-induced oxidative stress through attenuating calcium-dependent ER stress and mitochondrial dysfunction in undifferentiated PC12 cells
Q57046544Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)
Q50507691Malleability of human skeletal muscle sarcoplasmic reticulum to short-term training.
Q46293588Manganese interferes with calcium, perturbs ERK signaling, and produces embryos with no skeleton
Q35156179Microsecond molecular dynamics simulations of Mg²⁺- and K⁺-bound E1 intermediate states of the calcium pump
Q37889815Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease
Q36095330Mitochondrial Ca(2+) and neurodegeneration
Q50618470Mitochondrial Calcium Handling in Physiology and Disease.
Q41938333Mitsugumin 53 attenuates the activity of sarcoplasmic reticulum Ca(2+)-ATPase 1a (SERCA1a) in skeletal muscle
Q42389555Modes of Neuronal Calcium Entry and Homeostasis following Cerebral Ischemia
Q46452110Modulation of endoplasmic reticulum calcium pump expression during lung cancer cell differentiation.
Q35905846Molecular Signatures of Reduced Nerve Toxicity by CeCl3 in Phoxim-exposed Silkworm Brains
Q89460183Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism
Q37944859Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease
Q35196225Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori
Q39652636Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells
Q58057389Molecular profiling of the human nasal epithelium: A proteomics approach
Q38676197Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER.
Q27023012Multifaceted roles of STIM proteins
Q33768715Multifunctional carbon-nanotube cellular endoscopes
Q36221916Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis
Q35182763NFAT1 and NFAT3 cooperate with HDAC4 during regulation of alternative splicing of PMCA isoforms in PC12 cells
Q92005259NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland
Q55315068Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function.
Q47812801Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function
Q38179996Neuronal calcium signaling: function and dysfunction
Q36294691Nifetepimine, a dihydropyrimidone, ensures CD4+ T cell survival in a tumor microenvironment by maneuvering sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA).
Q93184934Oleic acid-loaded nanostructured lipid carrier inhibit neutrophil activities in the presence of albumin and alleviates skin inflammation
Q37739513Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).
Q41765036PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics.
Q36498165PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer
Q37023620Painful nerve injury decreases sarco-endoplasmic reticulum Ca²⁺-ATPase activity in axotomized sensory neurons
Q64069540Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes
Q26781824PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics
Q27008523Physiology of cholangiocytes
Q82442098Plant and animal type 2B Ca2+‐ATPases: Evidence for a common auto‐inhibitory mechanism
Q34878884Plasma membrane Ca-ATPases in the nervous system during development and ageing
Q36923109Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase
Q37889808Plasma membrane calcium ATPases and cancer.
Q34956508Plasma membrane calcium ATPases as novel candidates for therapeutic agent development
Q35757304Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.
Q37871358Plasma membrane calcium pump regulation by metabolic stress
Q37871359Plasma membrane calcium pumps and their emerging roles in cancer
Q34450960Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.
Q35143657Possible Biomarkers for the Early Detection of HIV-associated Heart Diseases: A Proteomics and Bioinformatics Prediction
Q37566439Proteomics of Skeletal Muscle: Focus on Insulin Resistance and Exercise Biology
Q91905163Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane
Q28391369Redox regulation of store-operated Ca2+ entry
Q47259491Reduced SERCA activity underlies dysregulation of Ca2+ homeostasis under atmospheric O2 levels
Q34260123Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis.
Q33941185Regulating cytoplasmic calcium homeostasis can reduce aluminum toxicity in yeast
Q42426145Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways.
Q35952596Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition.
Q90228537Regulation of Membrane Calcium Transport Proteins by the Surrounding Lipid Environment
Q36531972Regulation of presynaptic calcium in a mammalian synaptic terminal
Q38025471Regulation of sarco(endo)plasmic reticulum Ca2+-ATPase and calsequestrin gene expression in the heart
Q37501931Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease.
Q34878716Role of plasma membrane calcium ATPase 2 in spinal cord pathology
Q36292030SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2
Q46330392SERCA control of cell death and survival
Q89081010SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract
Q47096838STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes.
Q64087343Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells
Q37497785Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: relevance to arrhythmias and bio-pacemaker design
Q37889805Secretory pathway stress responses as possible mechanisms of disease involving Golgi Ca2+ pump dysfunction
Q57150089Signal detection and coding in the accessory olfactory system
Q36347658Signal integration by Ca(2+) regulates intestinal stem-cell activity
Q35128702Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques
Q36967497Spontaneous shaker rat mutant - a new model for X-linked tremor/ataxia
Q24310478Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7
Q28082709Stress responses from the endoplasmic reticulum in cancer
Q53314167Stromal interaction molecule 1 (STIM1) regulates sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase 1a (SERCA1a) in skeletal muscle.
Q59808586Structural basis for activation of plasma-membrane Ca-ATPase by calmodulin
Q36902125Structural requirements for inhibitory effects of bisphenols on the activity of the sarco/endoplasmic reticulum calcium ATPase
Q38049358Structure-function relationships in calpains.
Q24295118TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis
Q38072110Targeting Ca²⁺ transport in cancer: close reality or long perspective?
Q42105322The Ca(2+): H(+) coupling ratio of the plasma membrane calcium ATPase in neurones is little sensitive to changes in external or internal pH
Q37858339The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.
Q30486743The Concise Guide to PHARMACOLOGY 2013/14: transporters
Q38116698The Golgi Apparatus: Panel Point of Cytosolic Ca(2+) Regulation
Q39342378The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease
Q36139808The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.
Q92327821The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process
Q52584082The SERCA2: A Gatekeeper of Neuronal Calcium Homeostasis in the Brain.
Q52651096The degree of resistance of erythrocyte membrane cytoskeletal proteins to supra-physiologic concentrations of calcium: an in vitro study.
Q27015793The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology
Q30451399The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells
Q38092029The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease
Q30516388The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase
Q35592694The ins and outs of cellular Ca(2+) transport
Q37775995The interdependence of endothelin-1 and calcium: a review.
Q85832689The interplay between plasma membrane and endoplasmic reticulum Ca(2+)ATPases in agonist-induced temporal Ca(2+) dynamics
Q94461699The orphan solute carrier SLC10A7 is a novel negative regulator of intracellular calcium signaling
Q48850978The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation
Q37864720The plant Ca2+ -ATPase repertoire: biochemical features and physiological functions.
Q34576362The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium
Q38081907The plasma membrane calcium pump in health and disease
Q37904881The plasma membrane calcium pump in the hearing process: physiology and pathology
Q38191170The plasma membrane calcium pump: new ways to look at an old enzyme.
Q26865292The role of Ca2+ in the pathophysiology of pancreatitis
Q39334572The role of the ATP2C1 gene in Hailey-Hailey disease.
Q38714954The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
Q34733633The secretory pathway calcium ATPase PMR-1/SPCA1 has essential roles in cell migration during Caenorhabditis elegans embryonic development
Q42509852The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway
Q88946746Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's disease
Q38569070Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway
Q35549914Towards a quantitative theory of epidermal calcium profile formation in unwounded skin
Q90075066Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
Q36170493Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters
Q38392573Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production
Q41640652Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment
Q33758324cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism

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