Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly

scientific article published on April 2010

Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1139/O09-168
P698PubMed publication ID20453928
P5875ResearchGate publication ID44583959

P2093author name stringQiaozhu Su
Khosrow Adeli
Angela C Rutledge
P2860cites workDNA sequence of the human apolipoprotein B geneQ48340360
Translocation efficiency of apolipoprotein B is determined by the presence of beta-sheet domains, not pause transfer sequences.Q51805740
Modular structure of solubilized human apolipoprotein B-100. Low resolution model revealed by small angle neutron scattering.Q51941645
Functional analysis of disulfide linkages clustered within the amino terminus of human apolipoprotein B.Q52529684
Apolipophorin II/I, apolipoprotein B, vitellogenin, and microsomal triglyceride transfer protein genes are derived from a common ancestor.Q52570918
Identification of the lipoprotein initiating domain of apolipoprotein B.Q53651577
The assembly and secretion of apolipoprotein B-48-containing very low density lipoproteins in McA-RH7777 cells.Q53876239
The Amino-terminal Domain of Apolipoprotein B Does Not Undergo Retrograde Translocation from the Endoplasmic Reticulum to the CytosolQ56971895
Sweet bays of ERADQ57705927
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycleQ24296412
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsQ24307429
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERADQ24312778
Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycansQ24313146
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiPQ24316328
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneQ24336904
A novel ER alpha-mannosidase-like protein accelerates ER-associated degradationQ24522524
Recognition of the polyubiquitin proteolytic signalQ24530006
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membraneQ24530318
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membraneQ24550974
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradationQ24643067
Structure of the AAA ATPase p97Q27629334
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Ubiquitin-dependent protein degradationQ27931143
Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sitesQ27934760
Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulumQ27939552
Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cellsQ28188104
Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family businessQ28189675
Familial hypobetalipoproteinemia: genetics and metabolismQ28244204
Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistanceQ28244602
Translational control of apolipoprotein B mRNA: regulation via cis elements in the 5' and 3' untranslated regionsQ28262876
Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complexQ28269183
N-glycan processing in ER quality controlQ28271200
Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation stateQ28278880
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathwayQ28282028
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemiaQ28282776
The methylation of phosphatidylethanolamineQ28289280
The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an α–helical domainQ28296730
A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestineQ28301876
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytesQ28569109
Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteinsQ28573980
Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidationQ28590076
Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48Q28594252
The mammalian unfolded protein responseQ29547400
Recognition and processing of ubiquitin-protein conjugates by the proteasomeQ29547616
Roles of N-linked glycans in the endoplasmic reticulumQ29616458
Oxidized redox state of glutathione in the endoplasmic reticulumQ29619789
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestineQ33559393
Isolation and characterization of sulfhydryl and disulfide peptides of human apolipoprotein B-100.Q33700536
The role of the microsomal triglygeride transfer protein in abetalipoproteinemiaQ33913539
APOLIPOPROTEIN B: mRNA editing, lipoprotein assembly, and presecretory degradationQ34001437
Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicronsQ34056613
Traffic COPs of the early secretory pathwayQ34156645
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in miceQ34187435
Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich coreQ34713756
A three codon insertion/deletion polymorphism in the signal peptide region of the human apolipoprotein B (APOB) gene directly typed by the polymerase chain reactionQ35229040
Lipid disorders and mutations in the APOB gene.Q35861929
Evolution and mechanism of apolipoprotein B-containing lipoprotein assemblyQ36125680
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.Q36212658
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality controlQ36558102
Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence.Q36754186
Defining lipid-interacting domains in the N-terminal region of apolipoprotein B.Q36844718
Microsomal triglyceride transfer protein inhibition-friend or foe?Q37174377
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.Q37365629
Novel ubiquitin-dependent quality control in the endoplasmic reticulum.Q37561891
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL productionQ37698834
Messenger RNA editing and modificationQ38245105
Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminusQ39891720
Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100.Q39968492
The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathwayQ39972673
Insulin inhibition of apolipoprotein B mRNA translation is mediated via the PI-3 kinase/mTOR signaling cascade but does not involve internal ribosomal entry site (IRES) initiationQ40094431
Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cellsQ40095825
Apolipoprotein B: Structural and Metabolic HeterogeneityQ40148836
MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assemblyQ40220537
Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.Q40295259
Insulin-mediated suppression of apolipoprotein B mRNA translation requires the 5' UTR and is characterized by decreased binding of an insulin-sensitive 110-kDa 5' UTR RNA-binding proteinQ40374793
Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation.Q40477226
Apolipoprotein B-containing lipoprotein particle assembly: lipid capacity of the nascent lipoprotein particleQ40535906
Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER.Q40636844
The N-terminal 1000 residues of apolipoprotein B associate with microsomal triglyceride transfer protein to create a lipid transfer pocket required for lipoprotein assemblyQ40729235
The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesisQ40769306
Interaction of newly synthesized apolipoprotein B with calnexin and calreticulin requires glucose trimming in the endoplasmic reticulum.Q40924568
Cholesterol is required for the secretion of the very-low-density lipoprotein: in vivo studiesQ41234151
Brefeldin A reversibly inhibits the assembly of apoB containing lipoproteins in McA-RH7777 cellsQ41267545
Studies on the translocation of the amino terminus of apolipoprotein B into the endoplasmic reticulumQ41357823
Intracellular degradation of apolipoprotein B generates an N-terminal 70 kDa fragment in the endoplasmic reticulumQ41369077
Surface study of apoB1694-1880, a sequence that can anchor apoB to lipoproteins and make it nonexchangeableQ41572209
Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?Q42819400
Determination of the molecular mass of apolipoprotein B-100. A chemical approachQ42854876
Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasomeQ43508003
The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathwaysQ43564087
Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.Q43595417
Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH7777 cellsQ44028642
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient miceQ44094368
The N-linked oligosaccharides at the amino terminus of human apoB are important for the assembly and secretion of VLDL.Q44138802
CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humansQ44499486
Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins.Q45032494
Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemiaQ46573174
Phospholipid transfer activity of microsomal triacylglycerol transfer protein is sufficient for the assembly and secretion of apolipoprotein B lipoproteinsQ46944888
Human apolipoprotein B gene intestinal control regionQ46968517
Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.Q47073719
Microsomal triglyceride transfer protein promotes the secretion of Xenopus laevis vitellogenin A1.Q47293277
The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteinsQ47732277
Post-transcriptional gene regulatory mechanisms in eukaryotes: an overviewQ47736766
P433issue2
P921main subjectlipoproteinQ28350
P304page(s)251-267
P577publication date2010-04-01
P1433published inBiochemistry and Cell BiologyQ4914719
P1476titleApolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly
P478volume88

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