Cyclophilin D Deficiency Attenuates Mitochondrial Perturbation and Ameliorates Hepatic Steatosis.

scientific article published on 21 January 2018

Cyclophilin D Deficiency Attenuates Mitochondrial Perturbation and Ameliorates Hepatic Steatosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.29788
P698PubMed publication ID29356058

P50authorShanshan ShaoQ86873023
P2093author name stringWenbin Chen
Li Wang
Ling Gao
Chunxiao Yu
Xiaolei Wang
Xiaojing Liu
Qiu Li
Heng Du
Tao Bo
Jiajun Zhao
Mingqi Sun
Yongfeng Song
Xiaohui Su
Lifang Zhao
P2860cites workRole of mitochondria in nonalcoholic fatty liver diseaseQ27028142
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell deathQ28242653
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survivalQ28255981
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysQ28365886
Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver diseaseQ28396128
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic PlaquesQ30054591
Inhibition of extracellular cyclophilins with cyclosporine analog and development of atherosclerosis in apolipoprotein E-deficient mice.Q30316706
Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscleQ30414295
Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal ratsQ33782820
Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondriaQ34152722
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.Q34406704
Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.Q34502805
Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neuronsQ34575798
Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.Q34686552
Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat DietQ35109666
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).Q35907960
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Q36119444
NASH: a mitochondrial diseaseQ36122708
Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose MetabolismQ36227218
Blockade of cyclophilin D rescues dexamethasone-induced oxidative stress in gingival tissueQ36300798
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasisQ36600595
Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degenerationQ37404781
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's diseaseQ37463481
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosisQ37878020
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver diseaseQ38072666
XBP1s Is an Anti-lipogenic ProteinQ38291938
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusQ38319698
Effects of Moderate and Vigorous Exercise on Nonalcoholic Fatty Liver Disease: A Randomized Clinical TrialQ38390512
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.Q38680300
Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced DyslipidemiaQ39790828
Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistanceQ39925487
Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver DiseaseQ40444861
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and DesfluraneQ42507473
Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosisQ43237637
Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in miceQ44165193
Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigsQ45261151
High-fat diets impede the lowering effect of cyclosporine A on rat brain lipids and interact with the expression of apolipoproteins E and J.Q46434073
Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse modelQ48018603
High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition.Q48107838
Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.Q48286906
Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.Q50884722
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Q51324999
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.Q51330295
Cyclophilin D deficiency prevents diet-induced obesity in mice.Q51511202
Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.Q54338450
Inhibition of anoxia-induced injury in heart myocytes by cyclosporin AQ67884722
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)62-77
P577publication date2018-05-09
P1433published inHepatologyQ15724398
P1476titleCyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis
P478volume68

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cites work (P2860)
Q92576623A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models
Q59792643Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice
Q98281109Berberine improves intralipid-induced insulin resistance in murine
Q92655305Cell Death and Liver Disease
Q92361928Cyclophilin D participates in the inhibitory effect of high-fat diet on the expression of steroidogenic acute regulatory protein
Q91089901Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis
Q64255957Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function
Q98566245Mitochondrial glycerol 3-phosphate dehydrogenase deficiency aggravates hepatic triglyceride accumulation and steatosis
Q59809218SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1
Q64938925Saturated Fatty Acid-Enriched Diet-Impaired Mitochondrial Bioenergetics in Liver From Undernourished Rats During Critical Periods of Development.
Q93052987Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation

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