Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

scientific article published on October 2016

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2016.10.003
P932PMC publication ID5089850
P698PubMed publication ID27783936

P50authorHeinrich JasperQ17505142
Nuno Miguel LuisQ41046862
Pankaj KapahiQ67220597
Subhash D KatewaQ125306629
P2093author name stringPatrick Wai-Lun Li
Jason Karpac
Lifen Wang
Mauricio Ortega
Hansong Deng
P2860cites workGenetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.Q24815740
Maintaining tissue homeostasis: dynamic control of somatic stem cell activityQ26852586
Nutrient control of Drosophila longevityQ27002563
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegansQ27312348
Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferationQ27313953
Lifespan extension by preserving proliferative homeostasis in DrosophilaQ27345444
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiaeQ27935778
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Calorie restriction increases fatty acid synthesis and whole body fat oxidation ratesQ33752629
With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in agingQ33912952
A versatile method for cell-specific profiling of translated mRNAs in DrosophilaQ34336075
Fasting: molecular mechanisms and clinical applicationsQ34398790
Promoting health and longevity through diet: from model organisms to humansQ34468959
Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytesQ34752384
Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory loadQ35010090
PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER StressQ35577504
The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.Q35721948
The impact of the unfolded protein response on human diseaseQ36062081
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogasterQ36104670
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Drosophila and the genetics of the internal milieuQ36997692
Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in DrosophilaQ37320290
Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in DrosophilaQ37381743
Promoting longevity by maintaining metabolic and proliferative homeostasisQ37402142
PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespanQ37591950
Lipid-dependent regulation of the unfolded protein responseQ38301758
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Drosophila Melted modulates FOXO and TOR activity.Q38322883
Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent responseQ39687427
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magroQ40252579
Control of lipid metabolism by tachykinin in Drosophila.Q43144399
Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.Q47070881
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Q51324999
Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.Q52836196
P4510describes a project that usesImageJQ1659584
P433issue5
P921main subjecttriglycerideQ186319
lifetimeQ22675021
P304page(s)1207-1216
P577publication date2016-10-01
P1433published inCell ReportsQ5058165
P1476titleIntestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction
P478volume17

Reverse relations

cites work (P2860)
Q57055358Anatomy and Physiology of the Digestive Tract of
Q39050922Dietary restriction and lifespan: Lessons from invertebrate models
Q39258127Endoplasmic reticulum proteostasis impairment in aging
Q91645033GAS1 Deficient Enhances UPR Activity in Saccharomyces cerevisiae
Q60928052Gut-A Nexus Between Dietary Restriction and Lifespan
Q47154871Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
Q95840450Mechanisms, regulation and functions of the unfolded protein response
Q38697788Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila
Q38656102Proteostasis and ageing: insights from long-lived mutant mice.
Q91786756Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
Q58803097Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
Q42363448The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development

Search more.