PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status

scientific article published in August 2011

PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20110702
P698PubMed publication ID21609322

P2093author name stringDavid Bishop-Bailey
Mark J Holness
Mary C Sugden
Paul W Caton
P2860cites workSIRT1 deacetylates and positively regulates the nuclear receptor LXRQ24297669
Regulation of cellular metabolism by protein lysine acetylationQ24300091
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissueQ24677042
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Q28237795
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylationQ28275010
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humansQ28276159
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alphaQ28513388
Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expressionQ28564221
Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormoneQ28566344
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fluxQ29615102
Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissuesQ31957956
Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistanceQ33227081
Metabolic switching of human myotubes is improved by n-3 fatty acidsQ33993155
Diacylglycerol-mediated insulin resistanceQ34109119
Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinasesQ34572847
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Regulation of stearoyl-CoA desaturases and role in metabolismQ35599793
Liver X receptors as integrators of metabolic and inflammatory signalingQ36411128
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.Q36964392
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissuesQ37024437
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.Q37157342
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivoQ37267126
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.Q37388544
PPAR control: it's SIRTainly as easy as PGC.Q37601091
Liver X receptor in cholesterol metabolismQ37616915
Acetate metabolism and aging: An emerging connectionQ37755583
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.Q38336592
Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liverQ38341562
Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissueQ38360929
Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.Q40709001
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signalingQ42440719
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegalyQ44295528
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LQ44429399
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidationQ46220928
Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathwayQ46406553
Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.Q46947827
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)521-530
P577publication date2011-08-01
P1433published inBiochemical JournalQ864221
P1476titlePPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status
P478volume437

Reverse relations

cites work (P2860)
Q36224779Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth
Q38171358Dietary stimulators of the PGC-1 superfamily and mitochondrial biosynthesis in skeletal muscle. A mini-review
Q27303384Effects of fatty acid treatments on the dexamethasone-induced intramuscular lipid accumulation in chickens
Q33976342Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo
Q42467090Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals.
Q54240137LXRα gene expression, genetic variation and association analysis between novel SNPs and growth traits in Chinese native cattle.
Q48098684Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Q36343310MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1.
Q36466568Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease
Q38019568Mitochondrial sirtuins--a new therapeutic target for repair and protection in multiple sclerosis
Q35239136Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation
Q47341237Nutritional regulation of renal lipogenic factor expression in mice: comparison to regulation in the liver and skeletal muscle
Q33567491PGC-1α and fasting-induced PDH regulation in mouse skeletal muscle
Q36272807Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.
Q58730034Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
Q51282817SIRT3 gene expression but not SIRT3 subcellular localization is altered in response to fasting and exercise in human skeletal muscle.
Q28572786Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients
Q39489635The impact of a 48-h fast on SIRT1 and GCN5 in human skeletal muscle
Q37586141The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
Q36365212Transcriptional regulation of pyruvate dehydrogenase kinase

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