Oncogenes strike a balance between cellular growth and homeostasis

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Oncogenes strike a balance between cellular growth and homeostasis is …
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scholarly articleQ13442814

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P356DOI10.1016/J.SEMCDB.2015.08.005
P8608Fatcat IDrelease_4nnrj274cbh6zdb63unsi7zxyy
P3181OpenCitations bibliographic resource ID1358247
P932PMC publication ID4662909
P698PubMed publication ID26277544

P2093author name stringM Celeste Simon
Bo Qiu
P2860cites workSREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthQ24309283
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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingQ24536092
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxiaQ40835443
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiencyQ40890351
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.Q41983843
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.Q42874599
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinomaQ44043146
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activityQ46379013
Validation of mammalian target of rapamycin biomarker panel in patients with clear cell renal cell carcinoma.Q54325230
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mTOR signaling in growth control and diseaseQ24634174
Brick by brick: metabolism and tumor cell growthQ24656187
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growthQ24800550
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Q26852282
Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shiftQ26999365
Endoplasmic reticulum stress in malignancyQ27006434
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Nutrient-sensing mechanisms across evolutionQ27015819
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionQ27025886
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesisQ28218978
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398Q28237559
Coordinated regulation of protein synthesis and degradation by mTORC1Q28244300
RAS oncogenes: weaving a tumorigenic webQ28250360
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongationQ28291406
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesisQ28595034
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Signal transduction by reactive oxygen speciesQ29615230
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxiaQ29616650
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityQ29616651
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolismQ29617213
Metabolic reprogramming: a cancer hallmark even warburg did not anticipateQ29617612
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathwayQ29617805
MYC on the path to cancerQ29619979
Pancreatic cancers require autophagy for tumor growthQ29620331
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.Q30541918
The tumor suppressor folliculin regulates AMPK-dependent metabolic transformationQ33685916
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.Q33863055
Quantitative flux analysis reveals folate-dependent NADPH production.Q33924205
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell deathQ34393322
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cellsQ34536583
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Q34626763
mTORC1-mediated translational elongation limits intestinal tumour initiation and growthQ35007110
Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesisQ35079601
The role for autophagy in cancerQ35242506
Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor geneQ35452783
Transcriptional regulatory circuits controlling mitochondrial biogenesis and functionQ35683727
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activityQ35880387
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolismQ36319414
PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasisQ36435206
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growthQ36497999
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivoQ36532941
Translational control in cancer etiologyQ36555212
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsQ36895786
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressQ36902914
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasisQ37019194
Lipid droplets and cellular lipid metabolismQ37157015
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsQ37261134
Hypoxia-inducible factor 2 regulates hepatic lipid metabolismQ37302297
MYC-induced cancer cell energy metabolism and therapeutic opportunitiesQ37438881
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver diseaseQ37463911
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growthQ37576769
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.Q37599925
The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulatorQ38184207
Cellular and metabolic functions for autophagy in cancer cellsQ38256306
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesisQ38324237
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.Q38892263
Hif-2α promotes degradation of mammalian peroxisomes by selective autophagyQ38936369
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivationQ39030433
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.Q39067480
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.Q39252741
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.Q39372073
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.Q39382008
Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.Q39926383
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
HIF-dependent antitumorigenic effect of antioxidants in vivoQ40085629
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
cell growthQ189159
P304page(s)3-10
P577publication date2015-07-01
P1433published inSeminars in Cell & Developmental BiologyQ14330411
P1476titleOncogenes strike a balance between cellular growth and homeostasis
P478volume43

Reverse relations

cites work (P2860)
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Q26775306The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease

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