IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

scientific article

IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI95864
P932PMC publication ID5873889
P698PubMed publication ID29381485

P50authorChih-Hang Anthony TangQ87642429
Juan R Del ValleQ88395651
P2093author name stringAnthony Mancuso
Yan Xiang
Chi V Dang
Hong Xie
M Celeste Simon
Jin Cao
Chih-Chi Andrew Hu
Brian Keith
Danielle J Sanchez
Jun H Song
Roy Lan
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activationQ24304996
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small moleculeQ24596804
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaQ24598483
An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targetsQ24792966
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Endoplasmic reticulum stress in malignancyQ27006434
MYC activation is a hallmark of cancer initiation and maintenanceQ27026026
Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogasterQ27320947
BET bromodomain inhibition as a therapeutic strategy to target c-MycQ28247024
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell HomeostasisQ28389316
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acidsQ28481634
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.Q38892263
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survivalQ38996766
Endoplasmic Reticulum Stress and the Hallmarks of CancerQ39456845
Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine.Q40168257
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiencyQ40890351
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.Q41786115
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.Q41831125
Measuring ER stress and the unfolded protein response using mammalian tissue culture systemQ41898554
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysisQ42097322
N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cellsQ46809713
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.Q48838047
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.Q52372960
XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism.Q55031705
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
The unfolded protein response: controlling cell fate decisions under ER stress and beyondQ29615499
MYC on the path to cancerQ29619979
Reverse engineering of regulatory networks in human B cellsQ30004211
A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stressQ33641274
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell modelQ33734728
XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis.Q33739777
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Alteration of the lipid profile in lymphomas induced by MYC overexpressionQ33971890
Burkitt's lymphomaQ34030708
Therapeutic strategies to inhibit MYCQ34355349
Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesisQ35079601
N-myc can functionally replace c-myc in murine development, cellular growth, and differentiationQ35195543
Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolismQ35593211
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.Q35836097
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.Q36330343
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradationQ36348190
Burkitt lymphoma in the mouse.Q36376081
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growthQ36497999
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domainsQ36712468
Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinomaQ36818377
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsQ36895786
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stressQ36902914
Targeting MYCN in neuroblastoma by BET bromodomain inhibitionQ36903802
Neuroblastoma and MYCNQ37201479
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsQ37261134
IRE1: ER stress sensor and cell fate executorQ37282044
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Apoptotic signaling by c-MYC.Q37310199
Oncogenic mechanisms in Burkitt lymphomaQ37522401
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stabilityQ37622393
Albumin and mammalian cell culture: implications for biotechnology applicationsQ37725715
Stearoyl CoA desaturase 1: role in cellular inflammation and stressQ37972614
Spliced XBP1 promotes macrophage survival and autophagy by interacting with Beclin-1.Q38298631
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1300-1316
P577publication date2018-02-26
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleIRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
P478volume128

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cites work (P2860)
Q98778664Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma
Q90119301Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Q100694610Clarifying the translational potential of B-I09
Q98771144Endoplasmic Reticulum Stress in Bone Metastases
Q102211135Endoplasmic reticulum stress signals in the tumour and its microenvironment
Q90503839Even Cancer Cells Watch Their Cholesterol!
Q92578189FDA-approved drug screen identifies proteasome as a synthetic lethal target in MYC-driven neuroblastoma
Q99616359Inositol requiring enzyme 1α promotes Zika virus infection through regulating stearoyl-CoA desaturase 1 mediated lipid metabolism
Q89748947Natural products as modulators of eukaryotic protein secretion
Q52372960Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
Q92003537Pharmacological targeting of the unfolded protein response for disease intervention
Q89727329Targeting the Unfolded Protein Response in Hormone-Regulated Cancers
Q100725422The SUMO pathway in pancreatic cancer: insights and inhibition
Q94564104Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
Q92795478Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells

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