review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Arthur Kaser | Q88612415 |
P2093 | author name string | Richard S Blumberg | |
P2860 | cites work | Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1 | Q22011167 |
Inflammatory Bowel Disease | Q22248115 | ||
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Q22251069 | ||
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease | Q22252318 | ||
Interleukin-10 and the interleukin-10 receptor | Q24290912 | ||
Plasma cell differentiation requires the transcription factor XBP-1 | Q24291453 | ||
Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. | Q54488011 | ||
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. | Q54559569 | ||
A Genome Scan in 260 Inflammatory Bowel Disease-Affected Relative Pairs | Q57307963 | ||
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis | Q59053989 | ||
Guilt beyond a reasonable doubt | Q80540702 | ||
Recent insights into the integration of the intestinal epithelium within the mucosal environment in health and disease | Q82949838 | ||
The endoplasmic reticulum stress response in immunity and autoimmunity | Q37231726 | ||
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease | Q37318174 | ||
RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract | Q37535131 | ||
Bacterial flagellin is a dominant antigen in Crohn disease. | Q37698878 | ||
Paneth cells and inflammation dance together in Crohn's disease | Q37708712 | ||
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). | Q40164655 | ||
Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung | Q42827760 | ||
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders | Q44559402 | ||
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility | Q44808056 | ||
Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues | Q46078392 | ||
Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation | Q46965757 | ||
Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. 1. Taxonomy, fermentation, isolation and biological activities | Q46965775 | ||
HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. | Q47809974 | ||
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor | Q48059051 | ||
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP. | Q53595113 | ||
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. | Q53616050 | ||
HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. | Q53663069 | ||
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor | Q24292102 | ||
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development | Q24292104 | ||
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats | Q24298956 | ||
Reduced Paneth cell alpha-defensins in ileal Crohn's disease | Q24538724 | ||
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Q24550675 | ||
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Q24656576 | ||
Signal integration in the endoplasmic reticulum unfolded protein response | Q27860577 | ||
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus | Q27930818 | ||
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response | Q27938493 | ||
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase | Q27938837 | ||
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter | Q28119099 | ||
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells | Q28155919 | ||
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate | Q28187453 | ||
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria | Q28204776 | ||
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA | Q28214814 | ||
Stem cells, self-renewal, and differentiation in the intestinal epithelium | Q28294807 | ||
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice | Q28359871 | ||
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis | Q28472412 | ||
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 | Q28507338 | ||
Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands | Q28510479 | ||
The transcription factor XBP-1 is essential for the development and survival of dendritic cells | Q28512302 | ||
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response | Q28585314 | ||
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection | Q28586576 | ||
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation | Q28587525 | ||
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract | Q28587612 | ||
Colorectal cancer in mice genetically deficient in the mucin Muc2 | Q28588769 | ||
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks | Q28591575 | ||
An essential role in liver development for transcription factor XBP-1 | Q28593777 | ||
The mammalian unfolded protein response | Q29547400 | ||
Unravelling the pathogenesis of inflammatory bowel disease | Q29547551 | ||
Interleukin-10-deficient mice develop chronic enterocolitis | Q29547881 | ||
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production | Q29614472 | ||
Autophagy is activated for cell survival after endoplasmic reticulum stress | Q29614485 | ||
Human IRGM induces autophagy to eliminate intracellular mycobacteria | Q29614486 | ||
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells | Q29614565 | ||
Personal genomes: The case of the missing heritability | Q29614582 | ||
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility | Q29614872 | ||
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 | Q29614873 | ||
IRE1 signaling affects cell fate during the unfolded protein response | Q29615502 | ||
Self-eating and self-killing: crosstalk between autophagy and apoptosis | Q29617748 | ||
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection | Q29618129 | ||
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes | Q29620366 | ||
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis | Q30445748 | ||
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli | Q30940276 | ||
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response | Q33264844 | ||
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation | Q33269987 | ||
Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways | Q33330462 | ||
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant | Q33375721 | ||
A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells | Q33902236 | ||
AB(5) toxins: structures and inhibitor design | Q33927939 | ||
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine | Q34104685 | ||
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin | Q34186394 | ||
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. | Q34286908 | ||
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort | Q34389150 | ||
The immunology of mucosal models of inflammation | Q34542265 | ||
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression | Q34563098 | ||
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis | Q35596623 | ||
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility | Q35641138 | ||
Endoplasmic reticulum stress triggers autophagy | Q35690087 | ||
The role of the unfolded protein response in tumour development: friend or foe? | Q35968425 | ||
Mammalian defensins in the antimicrobial immune response | Q36134856 | ||
Lysosomes and autophagy in cell death control | Q36292872 | ||
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats | Q36364133 | ||
Paneth cell defensins: key effector molecules of innate immunity | Q36424314 | ||
Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling | Q36703897 | ||
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. | Q36870862 | ||
Hypoxia and gastrointestinal disease | Q37008518 | ||
Intestinal barrier dysfunction in inflammatory bowel diseases. | Q37214839 | ||
The intestinal stem cell | Q37217105 | ||
From endoplasmic-reticulum stress to the inflammatory response | Q37225354 | ||
P433 | issue | 3 | |
P921 | main subject | inflammatory bowel diseases | Q917447 |
endoplasmic reticulum | Q79927 | ||
inflammation | Q101991 | ||
P304 | page(s) | 156-163 | |
P577 | publication date | 2009-02-23 | |
P1433 | published in | Seminars in Immunology | Q15762658 |
P1476 | title | Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease | |
P478 | volume | 21 |
Q43232082 | "ER stress(ed out)!": Paneth cells and ischemia-reperfusion injury of the small intestine |
Q38556802 | A bacteriophages journey through the human body. |
Q40657742 | A comprehensive glossary of autophagy-related molecules and processes |
Q23757242 | A comprehensive glossary of autophagy-related molecules and processes (2nd edition) |
Q38239644 | A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress. |
Q47588273 | Accumulation of HLA-DR4 in Colonic Epithelial Cells Causes Severe Colitis in Homozygous HLA-DR4 Transgenic Mice |
Q87173878 | Activated macrophage-like synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis |
Q46642504 | Aluminum Activates PERK-EIF2α Signaling and Inflammatory Proteins in Human Neuroblastoma SH-SY5Y Cells |
Q58956237 | Are inherited thrombotic risk factors associated with fibrostenosis in Crohnʼs disease? |
Q27025911 | Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut |
Q37878446 | Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease. |
Q41441733 | Controversy over NOD2, inflammation, and defensins |
Q34025428 | Crohn's disease: NOD2, autophagy and ER stress converge |
Q35242749 | Detrusor myocyte autophagy protects the bladder function via inhibiting the inflammation in cyclophosphamide-induced cystitis in rats. |
Q37438514 | Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish |
Q33589732 | ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology |
Q36526352 | Effects of endoplasmic reticulum stress on the expression of inflammatory cytokines in patients with ulcerative colitis |
Q61480434 | Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis |
Q26825586 | Endoplasmic reticulum stress and inflammation |
Q35928460 | Endoplasmic reticulum stress and inflammation: mechanisms and implications in diabetic retinopathy |
Q37623437 | Endoplasmic reticulum stress and intestinal inflammation |
Q40282765 | Endoplasmic reticulum stress as a pro-fibrotic stimulus |
Q38371666 | Endoplasmic reticulum stress in intestinal epithelial cell function and inflammatory bowel disease |
Q53685081 | Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1). |
Q37760005 | Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis |
Q37774241 | Epithelial decision makers: in search of the 'epimmunome'. |
Q39217907 | Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx. |
Q33668770 | Expression and function of HSP110 family in mouse testis after vasectomy |
Q34500273 | Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis |
Q22676705 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) |
Q36277573 | HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells |
Q24613509 | Homeostasis and inflammation in the intestine |
Q55073227 | Impact of Paneth Cell Autophagy on Inflammatory Bowel Disease. |
Q35043873 | Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress |
Q29615500 | Inflammatory bowel disease |
Q41494246 | Inhibition of the Phosphatidylinositol-3-Kinase Pathway Abrogates Polyinosinic:Polycytidylic Acid–Stimulated Hyaluronan-Mediated Human Mucosal Smooth Muscle Cell Binding of U937 Monocytic Cells |
Q38125446 | Interplay of autophagy and innate immunity in Crohn's disease: a key immunobiologic feature |
Q37570542 | Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease |
Q47104587 | Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review |
Q37688137 | Joint involvement in inflammatory bowel disease: managing inflammation outside the digestive system |
Q35661537 | Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response |
Q33700025 | Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy |
Q26781311 | Mitochondrial dysfunction in inflammatory bowel disease |
Q84390175 | Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease |
Q34467234 | N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury |
Q35287033 | Prioritisation and network analysis of Crohn's disease susceptibility genes |
Q55517489 | Severe Burn-Induced Intestinal Epithelial Barrier Dysfunction Is Associated With Endoplasmic Reticulum Stress and Autophagy in Mice. |
Q37679694 | Strategies for treating idiopathic pulmonary fibrosis |
Q37365438 | TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5). |
Q47725450 | TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice |
Q35721948 | The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis. |
Q58802621 | The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human |
Q27023885 | The dopaminergic system in autoimmune diseases |
Q24339515 | The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease |
Q36083232 | The unfolded protein response and its role in intestinal homeostasis and inflammation. |
Q36945715 | Toward understanding success and failures in the use of selenium for cancer prevention |
Q36592776 | α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation |
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