Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

scientific article published on 23 February 2009

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.SMIM.2009.01.001
P932PMC publication ID4736746
P698PubMed publication ID19237300

P50authorArthur KaserQ88612415
P2093author name stringRichard S Blumberg
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Inflammatory Bowel DiseaseQ22248115
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseQ22251069
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseQ22252318
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Bacterial flagellin is a dominant antigen in Crohn disease.Q37698878
Paneth cells and inflammation dance together in Crohn's diseaseQ37708712
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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibilityQ44808056
Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissuesQ46078392
Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidationQ46965757
Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. 1. Taxonomy, fermentation, isolation and biological activitiesQ46965775
HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP.Q47809974
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factorQ48059051
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.Q53595113
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.Q53616050
HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response.Q53663069
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentQ24292104
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Reduced Paneth cell alpha-defensins in ileal Crohn's diseaseQ24538724
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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisQ24656576
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoterQ28119099
Proteasome inhibitors disrupt the unfolded protein response in myeloma cellsQ28155919
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateQ28187453
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteriaQ28204776
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Stem cells, self-renewal, and differentiation in the intestinal epitheliumQ28294807
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient miceQ28359871
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitisQ28472412
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1Q28507338
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glandsQ28510479
The transcription factor XBP-1 is essential for the development and survival of dendritic cellsQ28512302
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infectionQ28586576
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiationQ28587525
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractQ28587612
Colorectal cancer in mice genetically deficient in the mucin Muc2Q28588769
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
An essential role in liver development for transcription factor XBP-1Q28593777
The mammalian unfolded protein responseQ29547400
Unravelling the pathogenesis of inflammatory bowel diseaseQ29547551
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionQ29614472
Autophagy is activated for cell survival after endoplasmic reticulum stressQ29614485
Human IRGM induces autophagy to eliminate intracellular mycobacteriaQ29614486
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cellsQ29614565
Personal genomes: The case of the missing heritabilityQ29614582
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityQ29614872
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Q29614873
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Self-eating and self-killing: crosstalk between autophagy and apoptosisQ29617748
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionQ29618129
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genesQ29620366
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitisQ30445748
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coliQ30940276
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein responseQ33264844
Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammationQ33269987
Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathwaysQ33330462
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variantQ33375721
A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cellsQ33902236
AB(5) toxins: structures and inhibitor designQ33927939
Requirement of Math1 for secretory cell lineage commitment in the mouse intestineQ34104685
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensinQ34186394
A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.Q34286908
A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohortQ34389150
The immunology of mucosal models of inflammationQ34542265
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasisQ35596623
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibilityQ35641138
Endoplasmic reticulum stress triggers autophagyQ35690087
The role of the unfolded protein response in tumour development: friend or foe?Q35968425
Mammalian defensins in the antimicrobial immune responseQ36134856
Lysosomes and autophagy in cell death controlQ36292872
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic ratsQ36364133
Paneth cell defensins: key effector molecules of innate immunityQ36424314
Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signalingQ36703897
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.Q36870862
Hypoxia and gastrointestinal diseaseQ37008518
Intestinal barrier dysfunction in inflammatory bowel diseases.Q37214839
The intestinal stem cellQ37217105
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
P433issue3
P921main subjectinflammatory bowel diseasesQ917447
endoplasmic reticulumQ79927
inflammationQ101991
P304page(s)156-163
P577publication date2009-02-23
P1433published inSeminars in ImmunologyQ15762658
P1476titleEndoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease
P478volume21

Reverse relations

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