Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress

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Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/G3.115.017269
P932PMC publication ID4390581
P698PubMed publication ID25681259
P5875ResearchGate publication ID272297308

P50authorJulie HollienQ55302303
P2093author name stringJi Eun Lee
Nitin Phadnis
Kimberly Frizzell
McKenna Oney
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stressQ24309549
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
Links between metabolism and cancerQ24626229
Atf4 regulates obesity, glucose homeostasis, and energy expenditureQ24648259
HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogasterQ27324988
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
ER stress-induced inflammation: does it aid or impede disease progression?Q38033784
The unfolded protein response in secretory cell function.Q38039150
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review).Q38066202
Evolution of the unfolded protein response.Q38078141
New directions in ER stress-induced cell deathQ38083562
The impact of the endoplasmic reticulum protein-folding environment on cancer developmentQ38241996
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress responseQ38326929
Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formationQ39680674
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cellsQ39951457
Characterization of growth and metabolism of Drosophila melanogaster cells transfected with the rabies-virus glycoprotein geneQ40119479
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell deathQ40138480
ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalphaQ40161611
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cellsQ40232298
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
Cooperation and competition in the evolution of ATP-producing pathwaysQ43562868
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Hexosamine pathway metabolites enhance protein quality control and prolong life.Q45905618
ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cellsQ50336030
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.Q53129238
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathwayQ28298223
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Mfn2 modulates the UPR and mitochondrial function via repression of PERKQ28589398
The unfolded protein response: from stress pathway to homeostatic regulationQ29547396
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promotersQ33573484
2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2Q33578562
The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila.Q34610035
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.Q34771704
2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletionQ34977236
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cellsQ34988108
Regulation of sumo mRNA during endoplasmic reticulum stressQ34995137
Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potentialQ35614922
FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasisQ35841927
The impact of the unfolded protein response on human diseaseQ36062081
Fuel feeds function: energy metabolism and the T-cell responseQ36292868
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathwayQ36313774
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.Q36322684
Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells.Q36490338
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fateQ36619432
Unfolded protein response in Drosophila: why another model can make it fly.Q36771208
Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genesQ36895564
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.Q36954378
Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein responseQ37062069
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Activating transcription factor 4 is translationally regulated by hypoxic stressQ37349289
Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathwayQ37648367
Hypoxia and mitochondrial oxidative metabolismQ37691909
Redox signaling loops in the unfolded protein responseQ38000454
P433issue4
P921main subjectendoplasmic reticulumQ79927
Drosophila melanogasterQ130888
P304page(s)667-675
P577publication date2015-02-13
P1433published inG3Q5512701
P1476titleDrosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress
P478volume5

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Q41534569A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress.
Q37163899A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells
Q26863590Drosophila as a model for unfolded protein response research
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Q92445240Impact and Relevance of the Unfolded Protein Response in HNSCC
Q64044527Impact of Models in the Study and Treatment of Friedreich's Ataxia
Q91706671Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes
Q60934550Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis
Q89510675PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila
Q57462443Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival
Q58702700The unfolded protein response signaling and retinal Müller cell metabolism

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