IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma

scientific article

IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.9696
P932PMC publication ID5190060
P698PubMed publication ID27270308

P2093author name stringNing Wang
Chi-Ming Che
Man-Fung Yuen
Sai-Wah Tsao
Yibin Feng
Hor-Yue Tan
P2860cites workTargeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinomaQ38829170
Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.Q38934719
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.Q39299575
Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patientsQ39805787
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalinQ42029086
Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cellsQ42090033
Genipin induced apoptosis associated with activation of the c-Jun NH2-terminal kinase and p53 protein in HeLa cellsQ42946036
Antidepressant-like effect of genipin in miceQ43012552
Liver inflammation and cancer: The role of tissue microenvironment in generating the tumor-promoting niche (TPN) in the development of hepatocellular carcinomaQ45880681
Genipin inhibits RANKL-induced osteoclast differentiation through proteasome-mediated degradation of c-Fos protein and suppression of NF-κB activationQ48331492
Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link.Q53479578
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instabilityQ22242922
Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathwayQ26827218
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Anti-inflammatory evaluation of gardenia extract, geniposide and genipinQ28272853
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Genipin inhibits TNF-α-induced vascular smooth muscle cell proliferation and migration via induction of HO-1Q28535681
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisQ28589300
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigmQ29614349
Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-κB inactivation.Q34222153
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formationQ34282375
Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic miceQ34358426
Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinomaQ34431085
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomasQ34569613
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.Q35903501
Genipin attenuates sepsis by inhibiting Toll-like receptor signalingQ35973321
STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinomaQ36266490
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppressionQ36363789
CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFαQ36456715
Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approachQ36612202
The metastasis-promoting roles of tumor-associated immune cellsQ36972016
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationQ37594369
Stressed out about obesity: IRE1α-XBP1 in metabolic disordersQ37894253
Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cellsQ38469354
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
P304page(s)43792-43804
P577publication date2016-05-30
P1433published inOncotargetQ1573155
P1476titleIRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma
P478volume7

Reverse relations

cites work (P2860)
Q90123170Direct inhibition of TLR4/MyD88 pathway by geniposide suppresses HIF1α-independent VEGF expression and hepatocellular carcinoma angiogenesis
Q52361609Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1.
Q47120885Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicine Salvia chinensis Benth and its active ingredient protocatechualdehyde
Q49887906Targeting tumour microenvironment by tyrosine kinase inhibitor.
Q38716247Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway

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