Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

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Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function is …
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scholarly articleQ13442814

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P819ADS bibcode2013NatCo...4.1336S
P6179Dimensions Publication ID1001036852
P356DOI10.1038/NCOMMS2342
P932PMC publication ID4314219
P698PubMed publication ID23299886
P5875ResearchGate publication ID234089505

P2093author name stringNicholas J G Webster
Supriya Sen
Hassan Jumaa
P2860cites workThe SR protein familyQ21183897
Sorting out the complexity of SR protein functionsQ24539813
SR proteins in vertical integration of gene expression from transcription to RNA processing to translationQ24654094
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Transcription factors in liver development, differentiation, and regenerationQ28188359
SR proteins: a conserved family of pre-mRNA splicing factorsQ28240185
Specific commitment of different pre-mRNAs to splicing by single SR proteinsQ28262042
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationQ28365331
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defectsQ42498869
Conditional knockout mice to study alternative splicing in vivo.Q46234914
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth.Q52221702
Distinct functions of SR proteins in alternative pre-mRNA splicing.Q55066190
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancerQ72693775
p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damageQ73486371
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunctionQ74191142
Cited2 is required for normal hematopoiesis in the murine fetal liverQ28507033
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinaseQ28508079
The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expressionQ28511562
Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouseQ28512187
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndromeQ28512217
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.Q28582631
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscleQ28592239
A muscleblind knockout model for myotonic dystrophyQ28592365
Pre-mRNA processing reaches back to transcription and ahead to translationQ29615045
Expansion of the eukaryotic proteome by alternative splicingQ29615083
Pre-mRNA splicing and human diseaseQ29617335
Alternative pre-mRNA splicing and proteome expansion in metazoansQ29618540
Coping with stress: eIF2 kinases and translational controlQ29619787
SC35 plays a role in T cell development and alternative splicing of CD45.Q32138733
Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiationQ33935135
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instabilityQ34442378
Testing gene function early in the B cell lineage in mb1-cre miceQ35025083
Multiple roles of the SR protein family in splicing regulation.Q35031507
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brainQ35074709
Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitisQ35598120
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesisQ35830099
Aberrant and alternative splicing in cancerQ35936123
The gene encoding the splicing factor SF2/ASF is a proto-oncogeneQ36129226
Normal growth and development in the absence of hepatic insulin-like growth factor IQ36394699
Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growthQ36877253
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.Q37081953
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolismQ37338980
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viabilityQ37377347
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).Q37388151
XBP1: the last two decadesQ37649065
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elementsQ39444777
Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cellsQ39678654
SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicingQ39910304
Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20.Q40931954
Liver-enriched transcription factors and hepatocyte differentiation.Q40993765
Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA.Q41039414
P407language of work or nameEnglishQ1860
P304page(s)1336
P577publication date2013-01-01
P1433published inNature CommunicationsQ573880
P1476titleSplicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function
P478volume4

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cites work (P2860)
Q90362958A Coiled-Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine-Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway
Q36627944A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells
Q35342607A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila
Q91876277Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors
Q39416487Alternative RNA Splicing in the Pathogenesis of Liver Disease
Q54971907Alternative mRNA Splicing in the Pathogenesis of Obesity.
Q39295240Alternative splicing as a regulator of development and tissue identity.
Q51736279Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224.
Q34363904Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing
Q36289207Construction and evaluation of an adenoviral vector for the liver-specific expression of the serine/arginine-rich splicing factor, SRSF3.
Q92497903Degradation of splicing factor SRSF3 contributes to progressive liver disease
Q34791385Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice
Q93380799Distinct mechanisms govern the phosphorylation of different SR protein splicing factors
Q51504147Drug Synergism of Proteasome Inhibitors and Mitotane by Complementary Activation of ER Stress in Adrenocortical Carcinoma Cells.
Q89967443Dynamic Alternative Splicing During Mouse Preimplantation Embryo Development
Q36256649ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation.
Q91739640Early oleate deficiency leads to severe defects in fetal rat liver development
Q64282122Effect of ethanol on lipid metabolism
Q46430171Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis
Q35750740Exploring evidence of positive selection reveals genetic basis of meat quality traits in Berkshire pigs through whole genome sequencing
Q64376988Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice
Q28271141Hepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activity
Q55491884Identification and characterization of long noncoding RNAs and mRNAs expression profiles related to postnatal liver maturation of breeder roosters using Ribo-zero RNA sequencing.
Q37122588Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice.
Q92398990Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction
Q55315704Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
Q36101955PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells.
Q48251530Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1.
Q42701262Prenatal Exposure to Bisphenol A Disrupts Mouse Fetal Liver Maturation in a Sex-Specific Manner
Q48525587Primary Culture of Human Cumulus Cells Requires Stearoyl-Coenzyme A Desaturase 1 Activity for Steroidogenesis and Enhancing Oocyte In Vitro Maturation
Q58761006RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis
Q38531851Regulation of hepatocyte identity and quiescence.
Q38092678Regulation of splicing by SR proteins and SR protein-specific kinases
Q38170369Regulation of β-cell function by RNA-binding proteins
Q90283300Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)
Q55438078SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements.
Q35965275Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair
Q95642946Small Protein Hidden in lncRNA LOC90024 Promotes "Cancerous" RNA Splicing and Tumorigenesis
Q90072793Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability
Q41205843Splicing regulator SLU7 is essential for maintaining liver homeostasis
Q38929098Splicing-factor alterations in cancers
Q49368231Systematic analysis of the regulatory roles of microRNAs in postnatal maturation and metergasis of liver of breeder cocks
Q34717851The RNAissance family: SR proteins as multifaceted regulators of gene expression
Q47096516The role of H19, a long non-coding RNA, in mouse liver postnatal maturation
Q28083838The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression
Q47136712Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines
Q92597298iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

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