Lipid Droplet Biogenesis.

scientific article published on 9 August 2017

Lipid Droplet Biogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-CELLBIO-100616-060608
P932PMC publication ID6986389
P698PubMed publication ID28793795

P50authorRobert V FareseQ88209774
Tobias C WaltherQ91966491
P2093author name stringJeeyun Chung
P2860cites workACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterizationQ22003885
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymesQ22003886
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family membersQ24291503
Evolutionarily conserved gene family important for fat storageQ24305054
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cellsQ24318507
A class of dynamin-like GTPases involved in the generation of the tubular ER networkQ24322595
Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferaseQ24530606
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisQ24645996
TIP47 functions in the biogenesis of lipid dropletsQ24648200
The lipid droplet-a well-connected organelleQ26795725
The biophysics and cell biology of lipid dropletsQ26830071
Lipid droplet biogenesisQ27021518
The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sitesQ27310026
Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogensQ27313650
A role for phosphatidic acid in the formation of "supersized" lipid dropletsQ27339412
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphologyQ27932399
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progressionQ27933027
Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeastQ27933389
High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.Q27934676
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeastQ27937464
Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.Q27938087
The yeast lipin orthologue Pah1p is important for biogenesis of lipid dropletsQ27939057
A class of membrane proteins shaping the tubular endoplasmic reticulumQ27940194
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric proteinQ28116009
Brummer lipase is an evolutionary conserved fat storage regulator in DrosophilaQ47070072
Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulumQ48085236
Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulationQ48508135
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.Q51358415
Seipin ablation in mice results in severe generalized lipodystrophy.Q51373568
Subcellular location and topography of rat hepatic monoacylglycerol acyltransferase activity.Q52495674
Analyzing the functions and structure of the human lipodystrophy protein seipin.Q52647344
Characterization of the Drosophila lipid droplet subproteome.Q52665852
Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae.Q53239116
The enzymatic synthesis of triglycerides.Q55037369
Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesisQ57375287
Membrane topology of the human seipin proteinQ57567852
Binding of CTP: phosphocholine cytidylyltransferase to large unilamellar vesiclesQ70173767
Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomainsQ37047936
Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell CarcinomaQ37054261
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferaseQ37075101
A conserved role for atlastin GTPases in regulating lipid droplet sizeQ37092189
Lipid droplets and cellular lipid metabolismQ37157015
Targeting Fat: Mechanisms of Protein Localization to Lipid DropletsQ37157652
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolismQ28275690
Sterol esterification in yeast: a two-gene processQ28280662
Seipinopathy: a novel endoplasmic reticulum stress-associated diseaseQ28293837
COPI complex is a regulator of lipid homeostasisQ28474150
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondriaQ28509052
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestineQ28585013
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesQ28585713
Lipopenia and skin barrier abnormalities in DGAT2-deficient miceQ28585990
Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissueQ28587329
Seipin is required for converting nascent to mature lipid dropletsQ28829197
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseQ29614897
SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate AcyltransferaseQ30275524
A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans.Q30363241
Coatomer-dependent protein delivery to lipid dropletsQ30487734
Functional genomic screen reveals genes involved in lipid-droplet formation and utilizationQ30489849
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.Q30541918
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp functionQ30543173
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomainsQ30560524
Composition, structure and properties of POPC-triolein mixtures. Evidence of triglyceride domains in phospholipid bilayers.Q30613614
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.Q30651985
Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primatesQ32012173
Identification of MicroRNAs that control lipid droplet formation and growth in hepatocytes via high-content screeningQ33635237
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysisQ33673834
Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver diseaseQ33790167
In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopyQ33816259
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DgatQ33901239
The PAT family of lipid droplet proteins in heart and vascular cellsQ33942112
Further assembly required: construction and dynamics of the endoplasmic reticulum networkQ33962105
The role of lipid droplets in metabolic disease in rodents and humansQ34027148
The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid dropletsQ34027938
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.Q34085454
Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorptionQ34181429
The enzymes of neutral lipid synthesisQ34360744
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnoverQ37234369
Seipin regulates ER-lipid droplet contacts and cargo delivery.Q37515456
Mechanisms shaping the membranes of cellular organellesQ37540213
Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.Q37552358
Lipid droplet hijacking by intracellular pathogens.Q37835452
Cellular pathways of hereditary spastic paraplegiaQ38006054
ER structure and functionQ38088091
Balancing the fat: lipid droplets and human diseaseQ38112396
Function of seipin: new insights from Bscl2/seipin knockout mouse modelsQ38119807
Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitorsQ38126932
The genetics of NAFLD.Q38141714
Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null miceQ38300526
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulumQ38440540
Expanding roles for lipid droplets.Q38513121
COPI-TRAPPII activates Rab18 and regulates its lipid droplet associationQ38724924
Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytesQ38731637
The physics of lipid droplet nucleation, growth and buddingQ38821867
The Perilipins: Major Cytosolic Lipid Droplet-Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic HomeostasisQ38901501
Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biologyQ39029111
Lipid droplet growth: regulation of a dynamic organelleQ39148161
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.Q39250720
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cellsQ39322543
Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3Q39482440
Proteome of skeletal muscle lipid droplet reveals association with mitochondria and apolipoprotein a-I.Q39483811
DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activityQ40789063
Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary HepatocytesQ41189971
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl estersQ42041464
Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesiclesQ42254974
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytesQ42466809
Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysisQ42798291
Imaging of lipid biosynthesis: how a neutral lipid enters lipid dropletsQ42819132
A Model for Shaping Membrane Sheets by Protein ScaffoldsQ43248456
The lipid-droplet proteome reveals that droplets are a protein-storage depot.Q44410871
Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane trafficQ44642035
Lipids partition caveolin-1 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesisQ44786888
Analysis of lipid droplets in cardiac muscleQ45124271
Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway.Q45997661
Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.Q46258698
Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy.Q46920207
Analysis of yeast lipid droplet proteome and lipidomeQ46986353
Mechanisms determining the morphology of the peripheral ERQ34432619
Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegenerationQ34458474
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosisQ34675058
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.Q34790962
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesisQ34817393
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Seipin Is a Discrete HomooligomerQ34905160
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.Q34935273
Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage.Q34951180
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acidsQ34989773
Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamicsQ35220357
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sitesQ35621038
Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formationQ35621301
ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment.Q35717898
Identification of the major functional proteins of prokaryotic lipid dropletsQ35747753
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in miceQ35799806
The topology of the triacylglycerol synthesizing enzyme Lro1 indicates that neutral lipids can be produced within the luminal compartment of the endoplasmatic reticulum: Implications for the biogenesis of lipid dropletsQ35836206
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2Q35958448
An intimate collaboration between peroxisomes and lipid bodiesQ36117598
Proteomic study and marker protein identification of Caenorhabditis elegans lipid dropletsQ36144142
Antioxidant Role for Lipid Droplets in a Stem Cell Niche of DrosophilaQ36146773
A conserved family of proteins facilitates nascent lipid droplet budding from the ER.Q36210749
Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal EnteropathyQ36283397
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptorQ36320445
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosisQ36357941
Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR studyQ36378631
PML isoform II plays a critical role in nuclear lipid droplet formation.Q36428040
Lipid droplets control the maternal histone supply of Drosophila embryosQ36442007
DGAT1 mutation is linked to a congenital diarrheal disorderQ36498084
Pathophysiology of lipid droplet proteins in liver diseasesQ36553968
Rough sheets and smooth tubulesQ36562472
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid dropletsQ36791060
Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significanceQ36791761
Protein correlation profiles identify lipid droplet proteins with high confidenceQ36832443
P304page(s)491-510
P577publication date2017-08-09
P1433published inAnnual Review of Cell and Developmental BiologyQ4497277
P1476titleLipid Droplet Biogenesis
P478volume33

Reverse relations

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