The genetics of NAFLD.

scientific article

The genetics of NAFLD. is …
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scholarly articleQ13442814

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P356DOI10.1038/NRGASTRO.2013.182
P698PubMed publication ID24061205

P50authorQuentin M AnsteeQ42834905
P2093author name stringChristopher P Day
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
Potential etiologic and functional implications of genome-wide association loci for human diseases and traitsQ22066284
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Finishing the euchromatic sequence of the human genomeQ22122488
Are rare variants responsible for susceptibility to complex diseases?Q22337172
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseQ22337234
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Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)Q24535745
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Apolipoprotein C3 gene variants in nonalcoholic fatty liver diseaseQ24611284
Biological, clinical and population relevance of 95 loci for blood lipidsQ24622541
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variantsQ24633806
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humansQ24643492
A second generation human haplotype map of over 3.1 million SNPsQ24651939
The TDT and other family-based tests for linkage disequilibrium and associationQ24675685
A haplotype map of the human genomeQ24679827
The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyadQ27641368
The International HapMap ProjectQ27860695
Characterization of the human patatin-like phospholipase familyQ28248355
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceQ28255243
Newly identified loci that influence lipid concentrations and risk of coronary artery diseaseQ28264535
The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese populationQ28295369
I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver diseaseQ42963113
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.Q43014565
The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Q43024330
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.Q43107476
Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descentQ43257949
Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort.Q43565987
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.Q44030028
The utility of radiological imaging in nonalcoholic fatty liver disease.Q44116674
Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT valuesQ44458156
Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donorsQ44508808
Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in ratsQ44583413
Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitisQ44849407
A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.Q44851403
Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitisQ45070082
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone diseaseQ45345284
Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twinsQ46080116
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosisQ46080216
Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.Q46117666
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humansQ46118770
Ethnic differences in the prevalence of cryptogenic cirrhosisQ46186734
Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adultsQ46657358
Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene.Q50878523
The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status.Q51410082
The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health.Q51529673
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective StudyQ51541188
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.Q51732144
Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease.Q51757427
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.Q53555710
Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese.Q53910016
Polymorphism in the farnesyl diphosphate farnesyl transferase 1 gene and nonalcoholic fatty liver disease severity.Q54381048
Preoperative donor liver biopsy for adult living donor liver transplantation: Risks and benefitsQ57205222
A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer RiskQ57540252
Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphismsQ57659850
A position statement on NAFLD/NASH based on the EASL 2009 special conferenceQ61338101
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studiesQ62607244
The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liverQ62607247
Liver biopsy findings from healthy potential living liver donors: Reasons for disqualification, silent diseases and correlation with liver injury testsQ62617432
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitroQ63408528
Genome-wide association studies: past, present and futureQ63916518
Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindredsQ73143340
One hundred consecutive hepatic biopsies in the workup of living donors for right lobe liver transplantationQ78634574
Genomewide association studies--illuminating biologic pathwaysQ83658310
How big a problem is non-alcoholic fatty liver disease?Q84570168
Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective studyQ84760102
Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severityQ28297290
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosisQ28943317
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosisQ29417041
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver diseaseQ29417076
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in JapaneseQ29417094
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillinQ29417159
A HapMap harvest of insights into the genetics of common diseaseQ29614875
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapyQ29614896
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseQ29614897
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adultsQ29614911
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severityQ29614914
Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseQ29614930
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityQ29614932
Genetic mapping in human diseaseQ29614943
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohortsQ29614946
Genome-wide association studies for common diseases and complex traitsQ29615822
On the allelic spectrum of human diseaseQ29616298
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferaseQ30032295
Epidemiology and natural history of non-alcoholic steatohepatitisQ30449204
Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissueQ33359272
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysisQ33673834
A feed-forward loop amplifies nutritional regulation of PNPLA3Q33842841
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsQ33851563
The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver diseaseQ33937046
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver diseaseQ34101263
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver diseaseQ34101705
Association study designs for complex diseasesQ34186026
Imaging of hepatic steatosisQ34215183
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaQ34224637
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.Q34365079
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipaseQ34369246
Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of diseaseQ34427653
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.Q34449398
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndromeQ34503398
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivoQ34546130
Genome-wide association studies: theoretical and practical concernsQ34555195
Genomewide association studies and human diseaseQ34606556
Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic populationQ34618881
Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistanceQ34674263
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic diseaseQ34759018
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesQ34861754
AGA technical review on nonalcoholic fatty liver diseaseQ34982453
Prevalence of and risk factors for hepatic steatosis and nonalcoholic Fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes StudyQ35043760
Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern EuropeansQ35102868
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver diseaseQ35423296
A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescentsQ35564927
Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organQ35649446
Ethnicity and nonalcoholic fatty liver diseaseQ35754063
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescentsQ35783993
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver diseaseQ35809618
The epidemiology of fatty liverQ35920748
Heritability of nonalcoholic fatty liver diseaseQ36095663
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosisQ36357941
Multigenerational epigenetic adaptation of the hepatic wound-healing responseQ36374096
Mouse models in non-alcoholic fatty liver disease and steatohepatitis research.Q36377266
Apoptosis and necrosis in the liver: a tale of two deaths?Q36382247
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patientsQ36727795
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart StudyQ36807854
A common variant in the adiponutrin gene influences liver enzyme valuesQ37137544
Ethnic differences in hepatic steatosis: an insulin resistance paradox?Q37175282
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descentQ37197345
Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis predictionQ37255709
A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.Q37337449
Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesityQ37394350
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 geneQ37400771
Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonanceQ37552186
Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 proteinQ37756050
The importance of fatty liver disease in clinical practiceQ37766943
Genome-wide association studies: results from the first few years and potential implications for clinical medicineQ37827862
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosisQ38090905
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysisQ39396087
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general populationQ39693472
Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver diseaseQ39892915
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liverQ42096203
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)645-655
P577publication date2013-09-24
P1433published inNature Reviews Gastroenterology & HepatologyQ2108255
P1476titleThe genetics of NAFLD
P478volume10

Reverse relations

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