Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing

scientific article published on October 5, 2010

Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00388.2010
P953full work available at URLhttps://europepmc.org/articles/pmc3006250
http://intl-ajpendo.physiology.org/cgi/content/abstract/299/6/E1066
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20923962/?tool=EBI
https://europepmc.org/articles/PMC3006250
https://doi.org/10.1152/ajpendo.00388.2010
https://www.physiology.org/doi/pdf/10.1152/ajpendo.00388.2010
P932PMC publication ID3006250
P698PubMed publication ID20923962
P5875ResearchGate publication ID47349420

P2093author name stringJames M. Ntambi
Chad M. Paton
P2860cites workA simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cellsQ28204098
Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cellsQ28211294
Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonistQ28250185
Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cellsQ28291080
Modulation of liver X receptor signaling as novel therapy for prostate cancerQ28293791
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2Q28511448
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1Q28513196
Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubationQ28570312
Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cellsQ28576413
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.Q33283848
Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate dietQ34569462
Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activationQ35071237
ABCA1: at the nexus of cholesterol, HDL and atherosclerosisQ36745872
Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPsQ37155389
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosisQ37276342
Phase behavior of cholesteryl ester dispersions which model the inclusions of foam cellsQ39102374
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisQ39843795
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage diseaseQ39962919
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weightQ40040767
Upregulation of cellular triacylglycerol - free fatty acid cycling by oleate is associated with long-term serum-free survival of human breast cancer cells.Q40111026
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stressQ40286509
Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cellsQ40430794
Expression of caveolin-1 enhances cholesterol efflux in hepatic cellsQ40598222
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cellsQ40617368
Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structureQ40683418
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferationQ42461741
Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.Q42832143
ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickensQ44292914
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophagesQ44542540
Genetic ablation of caveolin-1 confers protection against atherosclerosisQ44620779
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitorsQ46480433
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosisQ46870199
Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat dietQ50082945
Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophagesQ74137900
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)E1066-75
P577publication date2010-10-05
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleLoss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
P478volume299

Reverse relations

cites work (P2860)
Q39271142Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells.
Q46879471Expression of genes associated with cholesterol and lipid metabolism identified as a novel pathway in the early pathogenesis of Mycobacterium avium subspecies paratuberculosis-infection in cattle
Q35783006Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions
Q89783547Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism
Q50527927Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
Q34978215Ontology based molecular signatures for immune cell types via gene expression analysis
Q89230444Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity
Q37163006SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice
Q37088201Targeting lipid metabolism for the treatment of anaplastic thyroid carcinoma
Q92022173The C18:3n6/C22:4n6 ratio is a good lipid marker of chronic kidney disease (CKD) progression
Q36005304The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
Q49787737The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer
Q36200423Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Search more.