Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization

scientific article

Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01601-13
P932PMC publication ID4054321
P698PubMed publication ID24732803

P2093author name stringDavid E Cohen
Yingxia Li
Masaru Yoshida
Shin Nishiumi
Baran A Ersoy
Yuki Kawano
P2860cites workStructure of human phosphatidylcholine transfer protein in complex with its ligandQ24299470
The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysisQ24322296
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingQ24563197
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liverQ24647278
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissueQ24655101
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
Fatty acid import into mitochondriaQ28138465
Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2Q28241203
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complexQ28567616
The glucagon receptor is required for the adaptive metabolic response to fastingQ28594780
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screeningQ33365467
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisQ34021724
Fatty acid oxidation disordersQ34112648
The key role of anaplerosis and cataplerosis for citric acid cycle function.Q34135762
Malonyl-CoA: the regulator of fatty acid synthesis and oxidationQ34352236
Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.Q34383662
Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubuleQ34574289
Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient miceQ34617976
Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolismQ34752001
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.Q34762441
Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAsQ34905070
Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose productionQ35131887
The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytesQ35316703
Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.Q35604665
Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolismQ35913011
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver diseaseQ36788344
Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster miceQ37004205
Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in miceQ37311451
Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signalingQ37646429
PC-TP/StARD2: Of membranes and metabolismQ37719141
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liverQ38327316
Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARalpha).Q42909202
CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.Q44026665
Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient miceQ44279995
Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose productionQ46903282
Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 elementQ50335984
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alphaQ80175296
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectphosphatidylcholineQ650187
fatty acidQ61476
P304page(s)2396-2408
P577publication date2014-04-14
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization
P478volume34

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cites work (P2860)
Q96127385Acot9 traffics mitochondrial short-chain fatty acids towards de novo lipogenesis and glucose production in the liver
Q50293670Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA
Q38849408Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism.
Q38289117Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure
Q51115896Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.
Q58726478Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats
Q42378386NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer.
Q50293796PCTP binds PC
Q51068461Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
Q35953045Physiological Consequences of Compartmentalized Acyl-CoA Metabolism
Q50058761Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1.
Q90273777Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis
Q36814649Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue
Q64375806Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis
Q47333902Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress
Q92635681gga-miRNA-18b-3p Inhibits Intramuscular Adipocytes Differentiation in Chicken by Targeting the ACOT13 Gene

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