Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway

scientific article published on 7 April 2016

Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP24217
P932PMC publication ID4823713
P698PubMed publication ID27052593
P5875ResearchGate publication ID300002694

P2093author name stringMichiko Saito
Kenji Kohno
Akio Tsuru
Yasutaka Imai
P2860cites workTranslational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stressQ24290818
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBQ24301555
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsQ24309442
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA SplicingQ27649529
The unfolded protein response signals through high-order assembly of Ire1Q27653139
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseQ28585314
Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell lineQ28586245
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Protein folding in the cellQ29547792
Coping with stress: eIF2 kinases and translational controlQ29619787
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Regulation of human STARD4 gene expression under endoplasmic reticulum stress.Q30811353
On the mechanism of sensing unfolded protein in the endoplasmic reticulumQ34230593
The RtcB RNA ligase is an essential component of the metazoan unfolded protein responseQ34691382
Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated regionQ34720944
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cellsQ34807567
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein responseQ35029280
Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro.Q35088080
Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomainQ35607951
IRE1α activation protects mice against acetaminophen-induced hepatotoxicityQ35760821
Negative feedback by IRE1β optimizes mucin production in goblet cellsQ36637632
ER stress and diseases.Q36731474
Regulated Ire1-dependent decay of messenger RNAs in mammalian cellsQ37309146
Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammalsQ37639817
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cellsQ37811174
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.Q38311676
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.Q39814866
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stressQ40006517
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.Q41854293
A transgenic mouse model for monitoring endoplasmic reticulum stressQ44711192
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteinsQ50336381
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-IIQ81144490
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)24217
P577publication date2016-04-07
P1433published inScientific ReportsQ2261792
P1476titleNovel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway
P478volume6

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cites work (P2860)
Q60050975A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation
Q103028898A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Q92919443A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells
Q57065820Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis
Q55397060Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes.
Q98205139Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Q93155378Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
Q90622179ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
Q57027930ER stress signalling has an activating transcription factor 6α (ATF6)-dependent 'off-switch'
Q39139204Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.
Q33730922Endoplasmic reticulum stress and inflammation in the central nervous system
Q40051888Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites.
Q28073452Endoplasmic reticulum stress in chondrodysplasias caused by mutations in collagen types II and X
Q39393398Fine-tuning PERK signaling for neuroprotection.
Q92255602Herpesviruses and the Unfolded Protein Response
Q64981077Hyperthermia induces therapeutic effectiveness and potentiates adjuvant therapy with non-targeted and targeted drugs in an in vitro model of human malignant melanoma.
Q95319800IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells
Q59357517Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection
Q64083926Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation
Q92698886Linking the Endoplasmic Reticulum to Parkinson's Disease and Alpha-Synucleinopathy
Q64950563Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling.
Q92932089Mitochondrial stress management: a dynamic journey
Q64911147Oleuropein and rutin protect against 6-OHDA-induced neurotoxicity in PC12 cells through modulation of mitochondrial function and unfolded protein response.
Q64115221Omentin protects H9c2 cells against docetaxel cardiotoxicity
Q47304409Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly
Q64055421Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function
Q41688608The Unfolded Protein Response in Amelogenesis and Enamel Pathologies
Q46273814The ins and outs of endoplasmic reticulum-controlled lipid biosynthesis
Q90080201Type I interferons and endoplasmic reticulum stress in health and disease
Q61798270Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons
Q58796905Virus and tumor microenvironment induced ER stress and unfolded protein response: from complexity to therapeutics

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