| scholarly article | Q13442814 |
| P356 | DOI | 10.1128/MCB.00677-14 |
| P953 | full work available at URL | http://eprints.whiterose.ac.uk/138558 |
| P932 | PMC publication ID | 4135558 |
| P698 | PubMed publication ID | 24958099 |
| P50 | author | Albena Dinkova-Kostova | Q56806438 |
| Paul Meakin | Q57167928 | ||
| John D. Hayes | Q38318853 | ||
| John F. Dillon | Q38545342 | ||
| Rory J. McCrimmon | Q42317155 | ||
| P2093 | author name string | Sudhir Chowdhry | |
| Michael L J Ashford | |||
| Shaun V Walsh | |||
| Ritu S Sharma | |||
| Fiona B Ashford | |||
| P2860 | cites work | Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 |
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| The interaction of hepatic lipid and glucose metabolism in liver diseases | Q26827770 | ||
| The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis | Q27319729 | ||
| An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements | Q28244853 | ||
| AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes | Q28369312 | ||
| Regulation of hepatic lipogenesis by the transcription factor XBP1 | Q28507784 | ||
| PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress | Q28511471 | ||
| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes | Q28575190 | ||
| The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds | Q28755952 | ||
| Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway | Q29547371 | ||
| Steatohepatitis: a tale of two "hits"? | Q29547771 | ||
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression | Q29615644 | ||
| Molecular mediators of hepatic steatosis and liver injury | Q29616709 | ||
| Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals | Q30497261 | ||
| AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance | Q33581151 | ||
| Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease | Q33828303 | ||
| Genetic control of de novo lipogenesis: role in diet-induced obesity | Q33867059 | ||
| Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. | Q33939951 | ||
| Reactive oxygen species enhance insulin sensitivity | Q33941647 | ||
| CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice | Q33943164 | ||
| Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state | Q33968008 | ||
| Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity | Q34181503 | ||
| Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism | Q34425926 | ||
| Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings | Q34815796 | ||
| Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice | Q35227185 | ||
| Detecting and quantifying apoptosis in tissue sections | Q79979207 | ||
| Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice | Q84145798 | ||
| Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet | Q84966488 | ||
| Oxidative inactivation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and subunit cross-linking involve different dithiol/disulfide centers. | Q52402425 | ||
| Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. | Q54060044 | ||
| Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. | Q54377170 | ||
| Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. | Q54397165 | ||
| Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. | Q54617615 | ||
| Free radical biology for medicine: learning from nonalcoholic fatty liver disease | Q38133184 | ||
| Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. | Q38289583 | ||
| Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet | Q38569922 | ||
| Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis | Q39000961 | ||
| The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613. | Q39245992 | ||
| Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation | Q39697365 | ||
| Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice | Q39975807 | ||
| UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. | Q42041480 | ||
| Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence | Q42157111 | ||
| Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice | Q43238371 | ||
| Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. | Q43242090 | ||
| Lipotoxicity in NASH. | Q44967579 | ||
| Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents | Q46079650 | ||
| NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. | Q46748175 | ||
| Beneficial role of Nrf2 in regulating NADPH generation and consumption | Q35231072 | ||
| Human fatty liver disease: old questions and new insights | Q35588477 | ||
| In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase | Q35612115 | ||
| Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. | Q35623033 | ||
| Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation | Q35684800 | ||
| NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | Q35931190 | ||
| The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism | Q36204119 | ||
| Nonalcoholic fatty liver disease: from steatosis to cirrhosis | Q36382279 | ||
| Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. | Q36410781 | ||
| Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet | Q36427702 | ||
| Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases | Q36572087 | ||
| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver | Q36596344 | ||
| Hepatic gene expression profiling in Nrf2 knockout mice after long-term high-fat diet-induced obesity | Q36845143 | ||
| Antioxidants reduce endoplasmic reticulum stress and improve protein secretion | Q36985084 | ||
| The Keap1-Nrf2 system prevents onset of diabetes mellitus | Q37036376 | ||
| Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2 | Q37044968 | ||
| HMGB1 in cancer: good, bad, or both? | Q37067481 | ||
| Liver lipid metabolism | Q37162701 | ||
| GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice | Q37170811 | ||
| Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. | Q37214176 | ||
| From endoplasmic-reticulum stress to the inflammatory response | Q37225354 | ||
| Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding | Q37231144 | ||
| Nrf2 deletion causes "benign" simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet | Q37305784 | ||
| Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells | Q37343526 | ||
| Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis | Q37362066 | ||
| Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide | Q37364482 | ||
| Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi. | Q37420626 | ||
| Emerging role of high-mobility group box 1 (HMGB1) in liver diseases | Q37446034 | ||
| Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway | Q37743477 | ||
| Reactive oxygen species and insulin resistance: the good, the bad and the ugly | Q37821109 | ||
| Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis | Q37953770 | ||
| New insights into ER stress-induced insulin resistance. | Q38024445 | ||
| Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation | Q38059585 | ||
| Toward clinical application of the Keap1-Nrf2 pathway | Q38105775 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | molecular biology | Q7202 |
| P304 | page(s) | 3305-20 | |
| P577 | publication date | 2014-09-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w | |
| P478 | volume | 34 |
| Q39565276 | A microdialysis method to measure in vivo hydrogen peroxide and superoxide in various rodent tissues. |
| Q37689036 | A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells. |
| Q49385295 | Activation of Nrf2 signaling by natural products-can it alleviate diabetes? |
| Q47104903 | Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate |
| Q55338790 | Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus. |
| Q64233507 | Berberine attenuates hepatic oxidative stress in rats with non-alcoholic fatty liver disease via the Nrf2/ARE signalling pathway |
| Q91801159 | Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond |
| Q32186681 | Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice |
| Q90602510 | Cinnamaldehyde exerts vasculoprotective effects in hypercholestrolemic rabbits |
| Q58553666 | Commentary: The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity |
| Q54110483 | Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction. |
| Q36574224 | Cytoprotective mechanism of ferulic acid against high glucose-induced oxidative stress in cardiomyocytes and hepatocytes |
| Q100995088 | Downregulation of Keap1 Confers Features of a Fasted Metabolic State |
| Q52649427 | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). |
| Q36788693 | Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet. |
| Q92415839 | Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression |
| Q33683799 | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. |
| Q38365029 | Immunoregulation by lipids during the development of non-alcoholic steatohepatitis |
| Q92861341 | Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C |
| Q28552676 | Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice |
| Q36563849 | Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. |
| Q28394732 | Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease |
| Q52575751 | NRF2 Induction for NASH Treatment: A New Hope Rises. |
| Q36387554 | NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies. |
| Q88582817 | NRF2 and the Hallmarks of Cancer |
| Q57476124 | NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells |
| Q35333384 | New considerations on hormetic response against oxidative stress |
| Q38705659 | Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies |
| Q37141714 | Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance |
| Q51246406 | Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. |
| Q51743310 | Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. |
| Q53624787 | Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK. |
| Q36236785 | Oxidative stress response and Nrf2 signaling in aging |
| Q28071596 | Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells |
| Q41678966 | Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy |
| Q91793212 | Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Step in Protection from Xenobiotics |
| Q57165448 | Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1 |
| Q38642318 | Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms |
| Q64069192 | Protection against HEMA-Induced Mitochondrial Injury by Nrf2 Activation |
| Q39253194 | ROS in Cancer: The Burning Question |
| Q35863707 | Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. |
| Q47113147 | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. |
| Q41623135 | The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. |
| Q38481021 | The emerging role of Nrf2 in mitochondrial function |
| Q55297562 | The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. |
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