Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

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Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1157580S
P356DOI10.1371/JOURNAL.PONE.0157580
P932PMC publication ID4917109
P698PubMed publication ID27333187

P50authorYoshimi NakagawaQ87764970
Hitoshi ShimanoQ87968959
Masaaki IsakaQ89084715
Yoshinori TakeuchiQ89817177
Takashi MatsuzakaQ90787935
Shigeru YatohQ114444342
Noriko Suzuki-KemuriyamaQ114444345
Motoko KubaQ114444346
Song-Iee HanQ114444347
Kazuto KobayashiQ68067035
Hirohito SoneQ39956334
Naoya YahagiQ42403191
P2093author name stringHiroshi Ohno
Hiroaki Suzuki
Nobuhiro Yamada
Katsuhiro Miyajima
Hitoshi Iwasaki
Dai Nakae
P2860cites workAre all n-3 polyunsaturated fatty acids created equal?Q27497371
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Steatohepatitis: a tale of two "hits"?Q29547771
Molecular mediators of hepatic steatosis and liver injuryQ29616709
Nonalcoholic fatty liver diseaseQ29619354
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesisQ29619888
Lipotoxicity in the liver.Q30355131
Epidemiology and natural history of non-alcoholic steatohepatitisQ30449204
Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storageQ42824398
Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 ratsQ44785856
A lipidomic analysis of nonalcoholic fatty liver disease.Q44931121
No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trialQ44997998
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.Q46955928
Elovl6 promotes nonalcoholic steatohepatitisQ58207361
A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty AcidsQ60642311
Prostaglandins, thromboxanes, and leukotrienes in inflammationQ69881376
Fatty liver: think globallyQ84135789
Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitisQ85307305
Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trialQ85319932
Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* studyQ87417591
C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosisQ33750735
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and InflammationQ34254403
Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver diseaseQ34357996
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4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activationQ34920009
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Nonalcoholic fatty liver disease: Roles of the gut and the liver and metabolic modulation by some dietary factors and especially long-chain n-3 PUFA.Q35753377
Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesisQ35757087
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD).Q35907960
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse modelQ36333590
Nonalcoholic fatty liver disease: from steatosis to cirrhosisQ36382279
Impact of dietary fat on the development of non-alcoholic fatty liver disease in Ldlr-/- miceQ36483906
Distribution, interconversion, and dose response of n-3 fatty acids in humansQ36536062
Fish oil -- how does it reduce plasma triglycerides?Q36584568
Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesisQ36623100
Fat-specific protein 27 regulates storage of triacylglycerolQ36662761
Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.Q37017917
The opposing effects of n-3 and n-6 fatty acidsQ37058217
N-3 polyunsaturated fatty acid regulation of hepatic gene transcriptionQ37156302
The epidemiology of nonalcoholic fatty liver disease: a global perspectiveQ37310275
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesityQ37393336
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.Q37657815
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolitesQ37777696
n-3 fatty acids in cardiovascular diseaseQ37893165
Cardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiologyQ38176690
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.Q38297724
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppressionQ38347368
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver diseaseQ38358419
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.Q39741460
Prostaglandins, Arachidonic Acid, and InflammationQ40122354
Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patientsQ40370241
Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat dietQ42711327
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectliver diseaseQ929737
metabolic dysfunction–associated steatotic liver diseaseQ1546498
atherosclerosisQ12252367
non-alcoholic fatty liverQ66299798
P304page(s)e0157580
P577publication date2016-06-22
P1433published inPLOS OneQ564954
P1476titleDifferent Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
P478volume11

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cites work (P2860)
Q50153963Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy
Q64972868Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa Zucker Rats.
Q60950066Effective Food Ingredients for Fatty Liver: Soy Protein β-Conglycinin and Fish Oil
Q36154945Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials
Q104461516Effects of dietary oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) on cholesterol metabolism in obese type-II diabetic KK-Ay mice
Q48304928Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis.
Q50080490Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis
Q38705146Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes
Q42283305Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice
Q33743274Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis.
Q89224431Nutrients, Nutraceuticals, and Xenobiotics Affecting Renal Health
Q39445103Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease
Q64913342Physiological effects of an oil rich in γ-linolenic acid on hepatic fatty acid oxidation and serum lipid levels in genetically hyperlipidemic mice.
Q47120918Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver.
Q60915982The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells

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