Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.20783
P698PubMed publication ID16001399
P5875ResearchGate publication ID7743690

P2093author name stringSanjay Bhanot
Xing Xian Yu
Brett P Monia
Sanjay K Pandey
Susan F Murray
Dingjiu Bao
Susan Kelly
Robert McKay
Songyuan Chen
Sheri L Booten
Xiu-Zhen Song
P2860cites workRole of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytesQ44007180
Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expressionQ44007196
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.Q44477314
An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosisQ45270105
Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoterQ46133867
Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscleQ47412626
Rates of mitochondrial and peroxisomal beta-oxidation of palmitate change during postnatal development and food deprivation in liver, kidney and heart of pigsQ48739277
Skeletal muscle triglyceride levels are inversely related to insulin action.Q51575343
High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat.Q51582379
High dietary fat promotes syndrome X in nonobese ratsQ73609365
Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feedingQ73842112
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family membersQ24291503
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisQ24645996
Lipopenia and skin barrier abnormalities in DGAT2-deficient miceQ28585990
Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferaseQ28609414
The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat.Q31806021
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DgatQ33901239
Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistanceQ34399523
Insulin resistance in type 2 diabetes: role of fatty acidsQ34580981
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.Q34790962
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypesQ34835012
Influence of plasma free fatty acids on lipoprotein synthesis and diabetic dyslipidemiaQ35210038
Insulin-sensitizing action of rosiglitazone is enhanced by preventing hyperphagia.Q38299766
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.Q42088836
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.Q42997321
Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterolQ43646231
Phenotypic correction of diabetic mice by adenovirus-mediated glucokinase expressionQ43748930
Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6-secreting tumorQ43762936
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
steatosisQ1365091
hyperlipidemiaQ1079120
P304page(s)362-371
P577publication date2005-08-01
P1433published inHepatologyQ15724398
P1476titleAntisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice
P478volume42

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