Hepatic fatty acid trafficking: multiple forks in the road

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Hepatic fatty acid trafficking: multiple forks in the road is …
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scholarly articleQ13442814

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P356DOI10.3945/AN.113.004648
P932PMC publication ID3823518
P698PubMed publication ID24228201
P5875ResearchGate publication ID258524656

P50authorDouglas MashekQ42873871
P2093author name stringDouglas G Mashek
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Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
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Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidationQ37189493
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Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesisQ37834857
The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver diseaseQ37925317
The role of mitochondria in insulin resistance and type 2 diabetes mellitusQ37930956
The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver diseaseQ37963122
Increased risk of cardiovascular disease and chronic kidney disease in NAFLD.Q38008136
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Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver diseaseQ38072666
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Sirtuins' modulation of autophagyQ38108575
Regulation of autophagy by stress-responsive transcription factorsQ38111103
Gene expression in human NAFLD.Q38292078
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Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasisQ28585179
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient miceQ28589371
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Mammalian mitochondrial glycerol-3-phosphate acyltransferaseQ28609581
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Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adultsQ29614911
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityQ29614932
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaQ29620443
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferaseQ30032295
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signalingQ30425815
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposityQ30433606
Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expressionQ30494849
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.Q30541918
Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidationQ33235063
Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assemblyQ33537983
Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism.Q33613991
Role of acylCoA binding protein in acylCoA transport, metabolism and cell signalingQ33637219
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysisQ33673834
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cQ33785270
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout miceQ33852162
Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid speciesQ33901997
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.Q33953637
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesisQ34021724
Uptake of individual free fatty acids by skeletal muscle and liver in manQ34074225
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemiaQ34094336
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver diseaseQ34101705
Liver fatty acid-binding protein and obesityQ34120131
Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liverQ34125393
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetaseQ34149531
Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed statesQ46921367
Overproduction of large VLDL particles is driven by increased liver fat content in man.Q46931621
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionQ46955933
Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men.Q47919939
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liverQ50336015
Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study.Q50665949
A role for seipin in lipid droplet dynamics and inheritance in yeast.Q50669487
Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.Q51353898
Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.Q51375339
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.Q51379331
Ultrasonographic and biochemical evaluation of visceral obesity in obese women with non-alcoholic fatty liver disease.Q51475558
Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease.Q51495818
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men.Q51523783
Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.Q51573455
Factors affecting liver uptake of serum free stearic acid-1-C14.Q51692999
Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass.Q51838864
Evaluation of the affinity and turnover number of both hepatic mitochondrial and microsomal carnitine acyltransferases: relevance to intracellular partitioning of acyl-CoAs.Q52083229
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.Q53224130
Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning.Q53485669
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.Q53555710
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.Q54191086
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.Q54495638
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the LiverQ57016669
Nonalcoholic Fatty Liver Disease in Severely Obese SubjectsQ58816508
Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding RegimensQ59487259
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesityQ64377000
The hepatic uptake of individual free fatty acids in sheep during noradrenaline infusionQ66950215
Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytesQ67993662
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinaseQ68082700
Compartmentation of hepatic fatty-acid-binding protein in liver cells and its effect on microsomal phosphatidic acid biosynthesisQ69499133
A Substrate- and Position-specific Acylation of sn-Glycerol 3-Phosphate by Rat Liver MitochondriaQ70504237
Significance of Adipose Tissue and Liver as Sites of Fatty Acid Synthesis in the Pig and the Efficiency of Utilization of Various Substrates for LipogenesisQ71235790
Inhibition of liver microsomal carnitine acyltransferases by sulphonylurea drugsQ72052203
Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studiesQ72133666
Lipogenesis in the pigeon: in vivo studiesQ72227352
Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cellsQ72571322
Contribution of de novo fatty acid synthesis to very low density lipoprotein triacylglycerols: evidence from mass isotopomer distribution analysis of fatty acids synthesized from [2H6]ethanolQ73053122
Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase AQ73064677
Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout miceQ74061464
UPTAKE OF PLASMA FREE FATTY ACIDS BY THE ISOLATED RAT LIVER: EFFECT OF GLUCAGONQ76554494
Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytesQ77313684
Vectorial acylation: linking fatty acid transport and activation to metabolic traffickingQ80685047
Anthropometric and clinical factors associated with mortality in subjects with nonalcoholic fatty liver diseaseQ85410881
Substrate inhibition of carnitine palmitoyltransferase by palmitoyl-CoA and activation by phospholipids and proteinsQ93629800
Comparative aspects of lipogenesis in mammalian tissuesQ93814281
Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathwaysQ34188050
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intoleranceQ34188075
Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?Q34215212
Peroxisomal lipid degradation via beta- and alpha-oxidation in mammalsQ34236856
Splanchnic lipolysis in human obesityQ34328357
Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and AdolescentsQ34355263
Disordered lipid metabolism and the pathogenesis of insulin resistanceQ34370965
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.Q34451430
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndromeQ34503398
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioningQ34511046
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretionQ34651716
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophyQ34742779
Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol HomeostasisQ34812700
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Biochemical and physiological function of stearoyl-CoA desaturaseQ34898764
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.Q34935273
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acidsQ34989773
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.Q35186665
Obesity, insulin resistance and free fatty acidsQ35204838
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingQ35235426
New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae.Q35855938
Invited review: pathology, etiology, prevention, and treatment of fatty liver in dairy cowsQ35891776
Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Q35897072
Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.Q35913725
Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 geneQ35922205
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liverQ35958436
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2Q35958448
FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1cQ36016844
Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidationQ36145221
Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderlyQ36339529
Nonalcoholic fatty liver disease (NAFLD): is it really a serious condition?Q36438823
Cellular fatty acid uptake: the contribution of metabolismQ36470872
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered miceQ36479005
Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.Q38309701
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistanceQ38314419
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese miceQ38323956
PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.Q38332175
Influence of Dietary Lipid on Lipogenic Enzyme Activities in Coho Salmon, Oncorhynchus kisutch (Walbaum)Q39145371
Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolismQ39193322
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cellsQ39322543
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.Q39616865
Caloric Homeostasis and Disorders of Fuel TransportQ39919368
Gluconeogenesis and lipogenesis in tissue from ruminant and nonruminant animalsQ39977411
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in miceQ40041201
Membrane binding proteins are the major determinants for the hepatocellular transmembrane flux of long-chain fatty acids bound to albuminQ40386781
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.Q40477651
Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates.Q40480335
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesisQ40691066
The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesisQ40769306
Lipoprotein metabolism and fattening in poultryQ41481264
Intracellular degradation of newly synthesized apolipoprotein B.Q41646693
Autophagy-lysosomal pathway is involved in lipid degradation in rat liver.Q41929863
FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytesQ42131271
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.Q42468549
Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in miceQ42508123
Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoterQ42835179
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individualsQ42946610
Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytesQ42982648
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesQ43552270
The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathwaysQ43564087
Fatty acid biosynthesis in liver and adipose tissue from dogsQ43987761
A species comparison of liver slice synthesis and secretion of triacylglycerol from nonesterified fatty acids in mediaQ44089541
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndromeQ44385945
Long-term follow-up of patients with nonalcoholic fatty liverQ44431564
Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liverQ44437158
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.Q44477314
Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver diseaseQ44664390
Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting miceQ44680979
Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver diseaseQ44726439
Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetesQ45168907
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanismsQ45300618
LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.Q45982093
Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic dietsQ46121875
Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver diseaseQ46215726
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.Q46442905
Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humansQ46579067
Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesisQ46660978
Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitusQ46667867
Relationship of hepatic steatosis to adipose tissue distribution in pediatric nonalcoholic fatty liver diseaseQ46872820
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
P304page(s)697-710
P577publication date2013-11-06
P1433published inAdvances in NutritionQ20821073
P1476titleHepatic fatty acid trafficking: multiple forks in the road
P478volume4

Reverse relations

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