Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis

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Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...738144Y
P356DOI10.1371/JOURNAL.PONE.0038144
P932PMC publication ID3364227
P698PubMed publication ID22666465
P5875ResearchGate publication ID225187355

P2093author name stringHiroyoshi Ariga
Jie Shen
Sanae M M Iguchi-Ariga
Takeshi Niki
Kenji Ishimoto
Takefumi Doi
Matthew S Goldberg
Takuya Yamane
Izumi Kato
Kazuko Takahashi-Niki
Shiori Yamaguchi
P2860cites workDJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationQ21146396
DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptorQ24291490
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosisQ24298775
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibitionQ24300958
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageQ24304102
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesisQ24304952
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2Q24305442
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cellsQ24306258
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathQ24306270
DJ-1 has a role in antioxidative stress to prevent cell deathQ24306633
Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1Q24309004
Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 geneQ24314566
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory elementQ24318461
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
Mitochondrial localization of DJ-1 leads to enhanced neuroprotectionQ24324226
DJ-1 binds to mitochondrial complex I and maintains its activityQ24324507
DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorQ24338249
Simvastatin is associated with a reduced incidence of dementia and Parkinson's diseaseQ24673755
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary ParkinsonismQ24797276
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 proteinQ28142804
DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complexQ28213052
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)Q28243657
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synucleinQ28290750
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with rasQ28305931
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Q28506681
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injuryQ28750483
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.Q33514644
Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoterQ34186131
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationQ34836156
Lower low-density lipoprotein cholesterol levels are associated with Parkinson's diseaseQ35869176
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's beenQ37426801
SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negativeQ38346363
DJ-1, a novel regulator of the tumor suppressor PTEN.Q39129969
DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1.Q39730498
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1Q39871794
DJ-1 decreases Bax expression through repressing p53 transcriptional activityQ40043929
Initiation of simian virus 40 DNA replication in vitroQ40138324
Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.Q40241827
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stressQ40349369
Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1.Q40386536
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activitiesQ40405262
Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptorQ40624696
DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequencesQ40820674
Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cellsQ42810942
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patientsQ42827820
DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.Q42828536
Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: A 2-year, placebo-controlled studyQ43783590
Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteinsQ44181135
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and functionQ44686491
Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cellsQ44842227
Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging StudyQ44937268
Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trialQ47950114
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat modelQ48465219
DJ-1 interacts with HIPK1 and affects H2O2-induced cell death.Q52568067
The distribution and composition of serum lipoproteins in eighteen animalsQ67236059
Immunosuppressive effect of mouse serum lipoproteins. I. In vitro studiesQ70731674
Distribution and characterization of the serum lipoproteins and apoproteins in the mouse, Mus musculusQ71073222
Hypocholesterolemic effect of sesame lignan in humansQ71303752
Effects of menopause and hormone replacement therapy on plasma lipids, lipoproteins and LDL-receptor activityQ73404235
Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activityQ73679218
Effects of soy isoflavones on atherosclerosis: potential mechanismsQ77664996
DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3Q81386853
Serum prolactin, leptin, lipids and lipoproteins levels during antipsychotics treatment in Parkinson's disease and related psychosisQ83949887
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P304page(s)e38144
P577publication date2012-05-30
P1433published inPLOS OneQ564954
P1476titleTranscriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis
P478volume7

Reverse relations

cites work (P2860)
Q36480874A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes
Q35754644A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake
Q35137313ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation
Q35534496Analysis of the basal chordate Botryllus schlosseri reveals a set of genes associated with fertility
Q28083118Cross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for Cancer
Q42288800DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
Q35793569DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death.
Q37642435DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.
Q35269486DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.
Q35571922Gender-dimorphic regulation of DJ1 and its interactions with metabolic proteins in streptozotocin-induced diabetic rats
Q35904237High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients
Q27468796Network analysis reveals common host protein/s modulating pathogenesis of neurotropic viruses
Q36899553Neuroprotective function of DJ-1 in Parkinson's disease
Q89431878PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5
Q64901146Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth.
Q41682410Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart
Q64980081Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
Q55332368Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice.
Q46931248The DJ-1 protein as a candidate biomarker in obstructive sleep apnea syndrome.
Q61804251The Role of Lipids in Parkinson's Disease
Q47393123Transcriptional Regulation of DJ-1.
Q35069291Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice

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