Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.0020327
P3181OpenCitations bibliographic resource ID1385437
P932PMC publication ID521171
P698PubMed publication ID15502868
P5875ResearchGate publication ID8214045

P50authorM. Flint BealQ67409129
P2093author name stringThomas Floss
Lichuan Yang
Asa Abeliovich
Alan Jonason
Cecile Martinat
Shoshana Shendelman
Thomas Leete
P2860cites workEarly-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutationQ57419094
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationQ21146396
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicityQ24297369
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibitionQ24300958
DJ-1 has a role in antioxidative stress to prevent cell deathQ24306633
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cellsQ24671346
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae.Q27936522
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquatQ28215248
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with rasQ28305931
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouseQ28585819
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neuronsQ28590748
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine systemQ28594502
Parkinson's disease: mechanisms and modelsQ29547424
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disordersQ29614754
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interferenceQ29615920
Oxidative stress in Parkinson's diseaseQ29618017
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic miceQ30476254
Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probesQ31138124
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.Q33925878
Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's diseaseQ34063895
L-3,4-dihydroxyphenylalanine increases the quantal size of exocytotic dopamine release in vitroQ34374217
Functional Genomics by Gene-Trapping in Embryonic Stem CellsQ34479293
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxinQ34520638
Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activityQ34526694
The nature of heme/iron-induced protein tyrosine nitrationQ35021938
Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquatQ40770196
Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementiaQ41712484
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.Q42524820
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cellsQ43718632
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteasesQ43728184
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.Q44428903
Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment.Q44495473
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.Q44591596
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Q45300712
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrilsQ46813521
Low frequency of alpha-synuclein mutations in familial Parkinson's diseaseQ48039687
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.Q48379973
Understanding cell death in parkinson's diseaseQ48389460
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodiesQ48401512
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synucleinQ48581887
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectoxidative stressQ898814
dopamineQ170304
Parkinson's diseaseQ11085
parkinsonian syndromeQ1531991
P304page(s)e327
P577publication date2004-11-01
P1433published inPLOS BiologyQ1771695
P1476titleSensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism
P478volume2

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