scholarly article | Q13442814 |
P50 | author | M. Flint Beal | Q67409129 |
P2093 | author name string | Thomas Floss | |
Lichuan Yang | |||
Asa Abeliovich | |||
Alan Jonason | |||
Cecile Martinat | |||
Shoshana Shendelman | |||
Thomas Leete | |||
P2860 | cites work | Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation | Q57419094 |
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation | Q21146396 | ||
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition | Q24300958 | ||
DJ-1 has a role in antioxidative stress to prevent cell death | Q24306633 | ||
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism | Q24321359 | ||
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells | Q24671346 | ||
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 | ||
Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae. | Q27936522 | ||
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat | Q28215248 | ||
DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras | Q28305931 | ||
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse | Q28585819 | ||
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons | Q28590748 | ||
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system | Q28594502 | ||
Parkinson's disease: mechanisms and models | Q29547424 | ||
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders | Q29614754 | ||
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference | Q29615920 | ||
Oxidative stress in Parkinson's disease | Q29618017 | ||
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice | Q30476254 | ||
Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes | Q31138124 | ||
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. | Q33925878 | ||
Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease | Q34063895 | ||
L-3,4-dihydroxyphenylalanine increases the quantal size of exocytotic dopamine release in vitro | Q34374217 | ||
Functional Genomics by Gene-Trapping in Embryonic Stem Cells | Q34479293 | ||
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin | Q34520638 | ||
Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity | Q34526694 | ||
The nature of heme/iron-induced protein tyrosine nitration | Q35021938 | ||
Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat | Q40770196 | ||
Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia | Q41712484 | ||
An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. | Q42524820 | ||
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells | Q43718632 | ||
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases | Q43728184 | ||
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. | Q44428903 | ||
Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment. | Q44495473 | ||
Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. | Q44591596 | ||
Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? | Q45300712 | ||
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils | Q46813521 | ||
Low frequency of alpha-synuclein mutations in familial Parkinson's disease | Q48039687 | ||
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. | Q48379973 | ||
Understanding cell death in parkinson's disease | Q48389460 | ||
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies | Q48401512 | ||
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein | Q48581887 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 11 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | oxidative stress | Q898814 |
dopamine | Q170304 | ||
Parkinson's disease | Q11085 | ||
parkinsonian syndrome | Q1531991 | ||
P304 | page(s) | e327 | |
P577 | publication date | 2004-11-01 | |
P1433 | published in | PLOS Biology | Q1771695 |
P1476 | title | Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism | |
P478 | volume | 2 |
Q37472304 | A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease |
Q35137313 | ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation |
Q30544278 | Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice |
Q47160614 | Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models |
Q28507691 | Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice |
Q37157838 | Alpha-synuclein and Parkinson's disease: a proteomic view |
Q37160563 | Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice |
Q33390827 | Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes |
Q38155480 | Animal models of Parkinson's disease: a gateway to therapeutics? |
Q24319830 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease |
Q49408164 | Atrial Natriuretic Peptide Acts as a Neuroprotective Agent in in Vitro Models of Parkinson's Disease via Up-regulation of the Wnt/β-Catenin Pathway. |
Q39052298 | Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. |
Q55048859 | Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease. |
Q36983148 | Comparative Genomics of Two Closely Related Wolbachia with Different Reproductive Effects on Hosts |
Q53071097 | Comparative analysis of Parkinson's disease-associated genes reveals altered survival and bioenergetics of parkin-deficient dopamine neurons in mice |
Q40224972 | Competition for amino acids between Wolbachia and the mosquito host, Aedes aegypti |
Q24541479 | Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. |
Q34122515 | Crystallization and preliminary X-ray data analysis of a DJ-1 homologue fromArabidopsis thaliana(AtDJ-1D) |
Q38292320 | Cysteine-mediated redox signalling in the mitochondria. |
Q41951528 | Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction |
Q30381288 | DJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and Invasion |
Q35793569 | DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death. |
Q24324507 | DJ-1 binds to mitochondrial complex I and maintains its activity |
Q35061270 | DJ-1 can inhibit microtubule associated protein 1 B formed aggregates |
Q48961308 | DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS. |
Q33749501 | DJ-1 contributes to adipogenesis and obesity-induced inflammation. |
Q24307823 | DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB |
Q39870296 | DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification |
Q24312506 | DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway |
Q52568067 | DJ-1 interacts with HIPK1 and affects H2O2-induced cell death |
Q34166108 | DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. |
Q21146396 | DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation |
Q39499315 | DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection. |
Q39922909 | DJ-1 protects against dopamine toxicity |
Q33905966 | DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex. |
Q33734076 | DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. |
Q36675623 | DJ-1 regulates mast cell activation and IgE-mediated allergic responses |
Q24338249 | DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor |
Q39967354 | DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains |
Q28506366 | DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc |
Q28534455 | DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE) |
Q39997452 | DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats |
Q54626415 | DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells |
Q34477562 | Decoupling of Host–Symbiont–Phage Coadaptations Following Transfer Between Insect Species |
Q37348709 | Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation |
Q99572093 | Dengue virus dominates lipid metabolism modulations in Wolbachia-coinfected Aedes aegypti |
Q34092616 | Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila |
Q64864377 | Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1 |
Q52690401 | Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control |
Q34178531 | Diversity and recombination in Wolbachia and Cardinium from Bryobia spider mites |
Q36002833 | Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53 |
Q36680414 | Drug discovery in Parkinson's disease: update and developments in the use of cellular models |
Q88574928 | Elevated expression of DJ-1 (encoded by the human PARK7 gene) protects neuronal cells from sevoflurane-induced neurotoxicity |
Q37330543 | Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway? |
Q44165299 | Entomology: incompatible mosquitoes |
Q38866805 | Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein |
Q27477593 | Evolutionary history of a mosquito endosymbiont revealed through mitochondrial hitchhiking |
Q48500499 | Expression of the Parkinson's disease protein DJ-1 during the differentiation of neural stem cells |
Q51033505 | Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer |
Q34523207 | Gene drive systems for insect disease vectors |
Q43988850 | Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production |
Q37583402 | Genetic insights into sporadic Parkinson's disease pathogenesis |
Q30537732 | Genetic mouse models of parkinsonism: strengths and limitations |
Q26852964 | Genetically engineered mouse models of Parkinson's disease |
Q28077356 | Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance |
Q28480475 | Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau |
Q24316421 | Human DJ-1 and its homologs are novel glyoxalases |
Q34400824 | Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene |
Q39300053 | Hypoxic preconditioning up-regulates DJ-1 protein expression in rat heart-derived H9c2 cells through the activation of extracellular-regulated kinase 1/2 pathway |
Q33613170 | Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe |
Q34800994 | Identification of the recognition sequence and target proteins for DJ-1 protease |
Q36963892 | In inclusion-body myositis muscle fibers Parkinson-associated DJ-1 is increased and oxidized |
Q34015950 | Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling |
Q38947611 | Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity |
Q40386536 | Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. |
Q24306270 | Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death |
Q47316460 | Intracellular metal binding and redox behavior of human DJ-1. |
Q49936913 | Introduction/Overview |
Q38845564 | Longevity-modulating effects of symbiosis: insights from Drosophila-Wolbachia interaction. |
Q34336431 | Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening |
Q51024194 | Macronutrients mediate the functional relationship between Drosophila and Wolbachia |
Q46709444 | Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease |
Q39545068 | MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function |
Q39503922 | Mitochondrial Dysfunction Precedes Other Sub-Cellular Abnormalities in an In Vitro Model Linked with Cell Death in Parkinson’s Disease |
Q34460675 | Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection |
Q58905388 | Mitochondrial Regulation by PINK1-Parkin Signaling |
Q24324226 | Mitochondrial localization of DJ-1 leads to enhanced neuroprotection |
Q48948098 | Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration |
Q36747314 | Molecular events underlying Parkinson's disease - an interwoven tapestry |
Q24793714 | Molecules that cause or prevent Parkinson's disease |
Q34552123 | Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants |
Q36441635 | Mosaic composition of ribA and wspB genes flanking the virB8-D4 operon in the Wolbachia supergroup B-strain, wStr. |
Q34944292 | Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging |
Q64110751 | Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury |
Q36347283 | Natural selection drove metabolic specialization of the chromatophore in Paulinella chromatophora |
Q37218550 | Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells |
Q38268886 | Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression |
Q36899553 | Neuroprotective Function of DJ-1 in Parkinson’s Disease |
Q35121851 | Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats |
Q38445326 | No evidence for bacteriophage WO orf7 correlation with Wolbachia-induced cytoplasmic incompatibility in the Culex pipiens complex (Culicidae: Diptera). |
Q36925400 | One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis |
Q36876274 | Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2. |
Q37509229 | Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle |
Q24309004 | Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1 |
Q39871794 | Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1 |
Q36559717 | Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner |
Q89431878 | PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5 |
Q28266665 | PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease |
Q34419476 | PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death. |
Q28592872 | Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis |
Q52559939 | Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process. |
Q24296667 | Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity |
Q39714333 | Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. |
Q35692589 | Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus |
Q42373911 | Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro |
Q36762401 | Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo |
Q37755118 | Peripheral biomarkers of Parkinson's disease as early reporters of central neurodegeneration. |
Q28260462 | Phylogenomic evidence for a common ancestor of mitochondria and the SAR11 clade |
Q35901239 | Physiology versus pathology in Parkinson's disease |
Q38036233 | Programmed cell death in Parkinson's disease |
Q30481530 | Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function |
Q40405262 | Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities |
Q36287875 | Radical medicine: treating ageing to cure disease |
Q34056577 | Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2 |
Q34999535 | Recent advances in our understanding of neurodegeneration |
Q36128032 | Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis |
Q47393112 | Regulation of Signal Transduction by DJ-1. |
Q34367267 | Renal dopamine receptors, oxidative stress, and hypertension |
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Q28272473 | Role of DJ-1 in Parkinson's disease |
Q64980081 | Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease. |
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Q34747606 | Role of stem cells in treatment of neurological disorder. |
Q58708199 | Secretome of Undifferentiated Neural Progenitor Cells Induces Histological and Motor Improvements in a Rat Model of Parkinson's Disease |
Q37003019 | Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease |
Q44360675 | Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. |
Q44344718 | Stable overexpression of DJ‐1 protects H9c2 cells against oxidative stress under a hypoxia condition |
Q30369057 | Structural effects of Parkinson's disease linked DJ-1 mutations. |
Q24339442 | Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection |
Q28757671 | Symbiosis as an adaptive process and source of phenotypic complexity |
Q38443979 | Tat-DJ-1 protects neurons from ischemic damage in the ventral horn of rabbit spinal cord via increasing antioxidant levels. |
Q37541373 | Temperature alters Plasmodium blocking by Wolbachia |
Q37440893 | The E163K DJ-1 mutant shows specific antioxidant deficiency |
Q38374332 | The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? |
Q48158987 | The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering |
Q36276992 | The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. |
Q24298775 | The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis |
Q36431372 | The Wolbachia WO bacteriophage proteome in the Aedes albopictus C/wStr1 cell line: evidence for lytic activity? |
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Q33410078 | The effects of, and interactions between, Cardinium and Wolbachia in the doubly infected spider mite Bryobia sarothamni. |
Q34369289 | The evolution of chronic infection strategies in the alpha-proteobacteria. |
Q39996806 | The genome of the obligate endobacterium of an AM fungus reveals an interphylum network of nutritional interactions |
Q38670012 | The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease |
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Q29615109 | Wolbachia: master manipulators of invertebrate biology |
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