Animal models of Parkinson's disease: a gateway to therapeutics?

scientific article published on January 2014

Animal models of Parkinson's disease: a gateway to therapeutics? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S13311-013-0234-1
P932PMC publication ID3899493
P698PubMed publication ID24158912
P5875ResearchGate publication ID258044531

P50authorJoseph JankovicQ6284337
P2093author name stringWeidong Le
Pavani Sayana
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Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's DiseaseQ42227324
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Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s DiseaseQ27301885
Edaravone guards dopamine neurons in a rotenone model for Parkinson's diseaseQ27335848
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposureQ28145614
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquatQ28215248
LRRK2 in Parkinson's disease: protein domains and functional insightsQ28235024
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Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialQ28296434
Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout miceQ28478469
Parkin-deficient mice are not a robust model of parkinsonismQ28504677
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Q28506681
Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired AutophagyQ28511536
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cellsQ28587554
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neuronsQ28590748
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
Loss of locus coeruleus neurons and reduced startle in parkin null miceQ28593443
Mitochondrial dysfunction and oxidative damage in parkin-deficient miceQ28593859
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body diseaseQ28740551
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Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Association between early-onset Parkinson's disease and mutations in the parkin geneQ29615733
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.Q30458705
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviorsQ30524899
Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouseQ30541996
Validation of the l-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonistsQ33228401
Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamineQ33344779
Tests to assess motor phenotype in mice: a user's guideQ33464903
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's diseaseQ33522039
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Q33594388
Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacityQ33617472
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's diseaseQ33754793
Behavioral phenotyping of mouse models of Parkinson's diseaseQ33820609
Sex differences in motor behavior in the MPTP mouse model of Parkinson's diseaseQ33835301
Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disordersQ33835599
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patientsQ37027502
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's diseaseQ37054679
Bladder and bowel dysfunction in Parkinson's diseaseQ37104716
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse modelQ37289669
Etiopathogenesis of Parkinson disease: a new beginning?Q37325334
Paraquat and Parkinson's diseaseQ37679695
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Dopamine receptor agonists and depression in Parkinson's diseaseQ37685695
Genetic animal models of Parkinson's diseaseQ37765030
Parkinson's disease: the non-motor issuesQ37899473
Explaining ADAGIO: A critical review of the biological basis for the clinical effects of rasagilineQ37939755
Spotlight on Rotigotine Transdermal Patch in Parkinsonʼs Disease†Q37960901
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.Q44251931
Influence of corticostriatal δ-opioid receptors on abnormal involuntary movements induced by L-DOPA in hemiparkinsonian ratsQ44334197
Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotypeQ44545273
The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA.Q44844737
Effects of high frequency deep brain stimulation on urine storage and voiding function in conscious minipigsQ44851830
Safinamide reduces dyskinesias and prolongs L-DOPA antiparkinsonian effect in parkinsonian monkeysQ45390357
DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in miceQ45865989
The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease.Q45903649
Effects of Plantago ovata husk on levodopa (with Carbidopa) bioavailability in rabbits with autonomic gastrointestinal disorders.Q46038792
Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's diseaseQ46046500
A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P + A53T transgenic mice.Q46061994
Granulocyte macrophage-colony stimulating factor protects against substantia nigra dopaminergic cell loss in an environmental toxin model of Parkinson's diseaseQ46074697
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease modelsQ46358011
Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degenerationQ46654865
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosetsQ46717685
The effects of short-term nicotine administration on behavioral and oxidative stress deficiencies induced in a rat model of Parkinson's diseaseQ47611823
Intranasally applied L-DOPA alleviates parkinsonian symptoms in rats with unilateral nigro-striatal 6-OHDA lesionsQ48027710
Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathwayQ48108789
The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat.Q48144769
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.Q48170542
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeysQ48197305
Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron lossQ48253717
100 years of Lewy pathologyQ48278741
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeysQ48325968
Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in miceQ48335901
Age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosetsQ48347120
Identification of a series of highly potent activators of the Nurr1 signaling pathwayQ48398582
Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine systemQ48403198
Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease modelQ48498265
Anti-Parkinsonian Effects of Nurr1 Activator in Ubiquitin-Proteasome System Impairment Induced Animal Model of Parkinson’s DiseaseQ48580281
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synucleinQ48581887
Neuronal nitric oxide synthase inhibition attenuates the development of L-DOPA-induced dyskinesia in hemi-Parkinsonian rats.Q48597422
Motor disorders and impaired electrical power of pallidal EEG improved by gallic acid in animal model of Parkinson's diseaseQ48659917
Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondriaQ48842987
Evaluation of antidepressant activity of ropinirole coadministered with fluoxetine in acute and chronic behavioral models of depression in ratsQ48939742
Paraquat induces behavioral changes and cortical and striatal mitochondrial dysfunctionQ48983439
Alpha‐synuclein in colonic submucosa in early untreated Parkinson's diseaseQ49037483
6-hydroxy-dopamine induced degeneration of central monoamine neuronsQ49122002
Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanismQ50259411
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson diseaseQ51051455
Paraquat-induced oxidative stress in drosophila melanogaster: effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acidQ52673945
Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s DiseaseQ52718634
Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease.Q52721046
Melatonin protects against rotenone‐induced cell injury via inhibition of Omi and Bax‐mediated autophagy in Hela cellsQ52726872
DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in MiceQ54105201
A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson's disease patientsQ60050820
Disulfiram and Diethyldithiocarbamate Intoxication Affects the Storage and Release of Striatal DopamineQ63431061
Animal models of Parkinson's diseaseQ83260343
AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trialsQ83836532
Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned ratsQ84747847
Pathogenesis of Parkinson's diseaseQ84882756
The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's diseaseQ33861795
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.Q33941736
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease modelsQ33964804
A neuroprotective role for angiogenin in models of Parkinson’s diseaseQ34024770
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Q34148223
Mutations in NR4A2 associated with familial Parkinson diseaseQ34166532
Role of LRRK2 kinase dysfunction in Parkinson diseaseQ34192817
Sleep alterations in an environmental neurotoxin-induced model of parkinsonismQ34203614
Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulationQ34223052
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neuronsQ34503671
REM Sleep Behavior Disorder in the Marmoset MPTP Model of Early Parkinson DiseaseQ35110581
Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neuronsQ35167964
Bladder, bowel, and sexual dysfunction in Parkinson's diseaseQ35209869
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neuronsQ35611727
Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3.Q35651220
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse modelQ35654251
SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular ChaperonesQ35686386
Modeling Parkinson's disease in primates: The MPTP modelQ35765748
Adenosine A2A receptor gene disruption protects in an α‐synuclein model of Parkinson's diseaseQ35799088
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's diseaseQ35894167
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in miceQ35946149
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s diseaseQ36063269
Late-onset Parkinsonism in NFκB/c-Rel-deficient miceQ36218699
Animal models of the non-motor features of Parkinson's diseaseQ36235578
A mechanism of paraquat toxicity involving nitric oxide synthaseQ36555889
Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for nQ36566007
Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α‐synucleinQ36585297
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discoveryQ36610346
Idiopathic REM sleep behaviour disorder in the development of Parkinson's diseaseQ36656691
α-Synuclein oligomers and clinical implications for Parkinson diseaseQ36718306
Transdermal rotigotine: a new non-ergot dopamine agonist for the treatment of Parkinson's diseaseQ36750148
In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?Q36976137
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s DiseaseQ36977322
Constant dopaminergic stimulation by transdermal delivery of dopaminergic drugs: a new treatment paradigm in Parkinson's diseaseQ37016310
P433issue1
P921main subjectParkinson's diseaseQ11085
P304page(s)92-110
P577publication date2014-01-01
P1433published inNeurotherapeuticsQ15716631
P1476titleAnimal models of Parkinson's disease: a gateway to therapeutics?
P478volume11

Reverse relations

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