Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay

scientific article published on 2 November 2017

Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1092429280
P356DOI10.1038/S41598-017-14780-4
P932PMC publication ID5668299
P698PubMed publication ID29097726

P50authorYoon Kyung JeonQ87637986
P2093author name stringDoo Hyun Chung
Hye Young Kim
Jae Sung Ko
Jae-Seon So
Jae Moon Koh
P2860cites workThe biology of NKT cellsQ28277482
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell HomeostasisQ28389316
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritisQ28589300
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human diseaseQ33828303
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.Q33997387
The transcription factor XBP1 is selectively required for eosinophil differentiationQ34483620
Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cellsQ34557052
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodentsQ35000991
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Q35041384
The regulatory role of Valpha14 NKT cells in innate and acquired immune response.Q35051569
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritisQ35894179
Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational statusQ36063732
NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 productionQ36402567
Palmitate and lipopolysaccharide trigger synergistic ceramide production in primary macrophagesQ36579422
Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress responseQ37170972
Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomesQ37552125
Diverse physiological effects of long-chain saturated fatty acids: implications for cardiovascular diseaseQ38049510
Getting RIDD of RNA: IRE1 in cell fate regulationQ38198370
Endoplasmic reticulum stress in immunityQ38286013
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells.Q38309617
Identification of a consensus element recognized and cleaved by IRE1 alpha.Q38343711
Free fatty acids sensitize dendritic cells to amplify TH1/TH17-immune responsesQ39743621
Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activationQ39768542
T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viabilityQ39985295
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.Q40105547
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cellsQ40147046
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cellsQ40313352
Regulation of NKT cells by Ly49: analysis of primary NKT cells and generation of NKT cell lineQ40776102
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.Q41005207
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.Q41716248
Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4.Q44945237
Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain.Q46714697
Free fatty acids: potential proinflammatory mediators in rheumatic diseasesQ50139520
Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation.Q50515978
Endoplasmic Reticulum Stress Response Promotes Cytotoxic Phenotype of CD8 + Intraepithelial Lymphocytes in a Mouse Model for Crohn's Disease-like IleitisQ57260226
Inhibition of dynamic protein palmitoylation in intact cells with tunicamycinQ71999632
Methods for detection, isolation and culture of mouse and human invariant NKT cellsQ80487867
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammationQ83782039
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)14940
P577publication date2017-11-02
P1433published inScientific ReportsQ2261792
P1476titlePalmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay
P478volume7

Reverse relations

cites work (P2860)
Q59808549A Metabolomics Approach Reveals Immunomodulatory Effects of Proteinaceous Molecules Derived From Gut Bacteria Over Human Peripheral Blood Mononuclear Cells
Q100733191Dexamethasone sodium phosphate loaded modified cyclodextrin based nanoparticles: An efficient treatment for Rheumatoid Arthritis
Q55283549IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
Q92049673Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
Q64055421Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function
Q61817013iNKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice

Search more.