The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms

scientific article published on 30 January 2012

The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.06351-11
P932PMC publication ID3302447
P698PubMed publication ID22290431

P50authorAshok KumarQ44603002
P2093author name stringBryant G Darnay
Yongwon Choi
Sanjay Srivastava
Shephali Bhatnagar
Pradyut K Paul
Vivek Mishra
P2860cites workTRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKLQ21092160
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factorQ24292102
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory responseQ24304232
The E3 ligase TRAF6 regulates Akt ubiquitination and activationQ24310343
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activationQ24321363
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophyQ24555065
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerQ24633015
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKLQ24654977
Autophagy in the Pathogenesis of DiseaseQ27860558
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic diseaseQ36910684
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-betaQ37052635
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylationQ37264046
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cellsQ37343526
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein responseQ37389501
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPsQ37579634
Autophagy in skeletal muscleQ37687551
Mitochondrial fission and remodelling contributes to muscle atrophy.Q39713513
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in miceQ39975807
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscleQ40056196
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiationQ40119268
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Q42041480
Fasting-related autophagic response in slow- and fast-twitch skeletal muscleQ43149447
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.Q44853225
Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetesQ45000394
Coexpression after electroporation of plasmid mixtures into muscle in vivoQ45875859
Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and functionQ46821957
Autophagy is required to maintain muscle mass.Q51411361
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Mechanisms underlying ubiquitinationQ27860656
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesQ28248180
TWEAK attenuates the transition from innate to adaptive immunityQ28284920
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expressionQ28565720
Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophyQ28571228
Identification of ubiquitin ligases required for skeletal muscle atrophyQ28582211
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagyQ28585634
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networksQ28591575
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cellsQ29614482
FoxO3 controls autophagy in skeletal muscle in vivoQ29614483
Ubiquitin signalling in the NF-kappaB pathwayQ29616322
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
The ubiquitin-proteasome pathway: on protein death and cell lifeQ29619270
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyQ29619282
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteinsQ29620170
Lysosomal proteolysis in skeletal muscleQ33222353
The ubiquitin-proteasome pathway and pathogenesis of human diseasesQ33540242
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activationQ33582021
The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice.Q33751732
The transcription factor ATF4 promotes skeletal myofiber atrophy during fastingQ33780239
TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokineQ34132318
Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.Q34439637
Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.Q34490064
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expressionQ34563098
Nuclear factor-kappa B signaling in skeletal muscle atrophy.Q34593476
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complexQ34673344
The many forks in FOXO's roadQ35079447
Ubiquitin-protein ligases in muscle wastingQ36241893
Intracellular signaling during skeletal muscle atrophyQ36288224
ATF4-dependent transcription mediates signaling of amino acid limitationQ36655003
Signal integration and diversification through the p62 scaffold proteinQ36686435
Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasomeQ36749044
P4510describes a project that usesImageQuantQ112270642
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)1248-1259
P577publication date2012-01-30
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms
P478volume32

Reverse relations

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