Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet

scientific article

Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJLT.201100309
P932PMC publication ID3348618
P698PubMed publication ID22582025
P5875ResearchGate publication ID224951261

P50authorMing XuQ56476108
P2093author name stringSusan E Carlson
John Turk
Bin Deng
Hao Zhu
Ying Guo
Daniel Aires
Wenfang Wang
Helin Ding
Jennifer R Frontera
Karen L Kover
P2860cites workElectrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty ratsQ74307630
Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cellsQ22010986
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulumQ24338800
Regulation of hepatic lipogenesis by the transcription factor XBP1Q28507784
Absence of a reductase, NCB5OR, causes insulin-deficient diabetesQ28512196
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturaseQ33507261
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Q33993695
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell deathQ34564595
Ncb5or deficiency increases fatty acid catabolism and oxidative stressQ34719530
Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cellsQ35256609
Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationshipsQ35883220
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetesQ35923385
Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.Q36097167
Fatty acid signaling in the beta-cell and insulin secretionQ36666157
Glucolipotoxicity: fuel excess and beta-cell dysfunction.Q36861036
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetesQ37019642
The role for endoplasmic reticulum stress in diabetes mellitusQ37019672
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulumQ37186859
ATF6 modulates SREBP2-mediated lipogenesis.Q37260315
Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetesQ38298818
Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese miceQ38303595
Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acidsQ39980266
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosisQ40294776
Suppression of beta cell energy metabolism and insulin release by PGC-1alphaQ42799597
Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetesQ43252759
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.Q43687834
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.Q43972538
Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicityQ46923599
Phenotypic variations between a fat-preferring strain and a macronutrient non-preferring strain of mouseQ59328652
What if Minkowski had been ageusic? An alternative angle on diabetesQ67584870
P433issue3
P304page(s)233-243
P577publication date2011-12-22
P1433published inEuropean Journal of Lipid Science and TechnologyQ15751683
P1476titleBeta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet
P478volume114

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cites work (P2860)
Q33619491Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis
Q47778534NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice
Q26752335PGC-1α, glucose metabolism and type 2 diabetes mellitus

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